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How to get fromFrederick to Greenvilleby bus, plane, bus (Greyhound, Flixbus), train, car, or taxi

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There are 8 ways to get from Frederick to Greenville by bus, plane, bus (Greyhound, Flixbus), train, car, or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Baltimore-Washington International Airport, fly to Greenville–Spartanburg International Airport

    best
    1. Take the bus from Frederick Bayrunner Office to Baltimore Airportbus bus
    2. Fly from Baltimore-Washington International Airport (BWI) to Greenville–Spartanburg International Airport (GSP)plane plane BWI - GSP
    3h 48m
    $199–732

  2. Drive 480.2 mi

    cheapest
    1. Drive from Frederick to Greenvillecar car 480.2 mi
    9h 11m
    $88–127

  3. Bus

    1. Take the bus from Frederick Bus Station to Washington Union Stationbus bus
    2. Take the bus from Washington Union Station to Charlotte Bus Stationbus bus
    3. Take the bus from Charlotte to Taqueria Guadalajara - Greenvillebus bus
    14h 14m
    $124–298

  4. Train, bus

    1. Take the train from FREDERICK MARC eb to Washington Union Stationtrain train
    2. Take the train from Washington Union Station to Charlotte Amtrak Stationtrain train
    3. Take the bus from Charlotte to Taqueria Guadalajara - Greenvillebus bus
    14h 44m
    $178–424

  5. Train to Ronald Reagan Washington National Airport, fly to Greenville–Spartanburg International Airport

    1. Take the train from FREDERICK MARC eb to ROCKVILLE MARC ebtrain train
    2. Fly from Ronald Reagan Washington National Airport (DCA) to Greenville–Spartanburg International Airport (GSP)plane plane DCA - GSP
    4h 49m
    $172–912

  6. Bus to Washington Dulles International Airport, fly to Greenville–Spartanburg International Airport

    1. Take the bus from Frederick Transit Station to Market St & Harrison Stbus bus
    2. Fly from Washington Dulles International Airport (IAD) to Greenville–Spartanburg International Airport (GSP)plane plane IAD - GSP
    4h 57m
    $119–550

  7. Train to Ronald Reagan Washington National Airport, fly to Asheville Regional Airport, taxi

    1. Take the train from FREDERICK MARC eb to ROCKVILLE MARC ebtrain train
    2. Fly from Ronald Reagan Washington National Airport (DCA) to Asheville Regional Airport (AVL)plane plane DCA - AVL
    3. Take the taxi from Asheville-Airport-AVL to Greenvilletaxi taxi
    5h 24m
    $237–737

  8. Train, bus via Lynchburg

    1. Take the train from FREDERICK MARC eb to Washington Union Stationtrain train
    2. Take the bus from Washington Union Station to Lynchburg Amtrak Stationbus bus
    3. Take the train from Lynchburg to Charlotte Amtrak Stationtrain train
    4. Take the bus from Charlotte to Taqueria Guadalajara - Greenvillebus bus
    16h 33m
    $152–369

Baltimore-Washington International Airport (BWI) to Greenville–Spartanburg International Airport (GSP) flights

Calendar29Weekly Planes
Duration2h 11mAverage Duration
Ticket$98Cheapest Price
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Questions & Answers

Map of how to get from Frederick to Greenville.ExpandLaunch map view
  • Distance: 486.3 mi
  • Duration: 3h 48m

What companies run services between Frederick, MD, USA and Greenville, SC, USA?

You can take a bus from Frederick Bus Station to Greenville via Washington Union Station, Charlotte Bus Station, Trade St & Graham St, Transit Center- Bay A, Transit Center- Bay O, Tryon St & Dorton St, Charlotte, and Taqueria Guadalajara - Greenville in around 14h 14m.

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