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How to get fromFrederick to Knoxvilleby bus, plane, train, car, bus (Flixbus), or bus (Greyhound)

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There are 10 ways to get from Frederick to Knoxville by bus, plane, train, car, bus (Flixbus), or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Baltimore-Washington International Airport, fly to Mcghee Tyson Airport

    best
    1. Take the bus from Frederick Bayrunner Office to Baltimore Airportbus bus
    2. Fly from Baltimore-Washington International Airport (BWI) to Mcghee Tyson Airport (TYS)plane plane BWI - TYS
    3h 57m
    $244–906

  2. Drive 473.2 mi

    cheapest
    1. Drive from Frederick to Knoxvillecar car 473.2 mi
    7h 55m
    $87–125

  3. Bus, train via Farragut

    1. Take the bus from Frederick Transit Center to BWI Amtrak Stationbus bus
    2. Take the train from BWI Thurgood Marshall to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York to Knoxvillebus bus Nyc
    18h 33m
    $296–1,040

  4. Train to Ronald Reagan Washington National Airport, fly to Mcghee Tyson Airport

    1. Take the train from FREDERICK MARC eb to ROCKVILLE MARC ebtrain train
    2. Fly from Ronald Reagan Washington National Airport (DCA) to Mcghee Tyson Airport (TYS)plane plane DCA - TYS
    4h 56m
    $232–1,187

  5. Bus to Washington Dulles International Airport, fly to Mcghee Tyson Airport

    1. Take the bus from Frederick Transit Station to Market St & Harrison Stbus bus
    2. Fly from Washington Dulles International Airport (IAD) to Mcghee Tyson Airport (TYS)plane plane IAD - TYS
    4h 56m
    $159–695

  6. Train to Ronald Reagan Washington National Airport, fly to Asheville Regional Airport, drive

    1. Take the train from FREDERICK MARC eb to ROCKVILLE MARC ebtrain train
    2. Fly from Ronald Reagan Washington National Airport (DCA) to Asheville Regional Airport (AVL)plane plane DCA - AVL
    3. Drive from Asheville-Airport-AVL to Knoxvillecar car
    6h 36m
    $119–602

  7. Train, bus

    1. Take the train from FREDERICK MARC eb to Washington Union Stationtrain train
    2. Take the train from Washington Union Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    18h 36m
    $210–325

  8. Bus, train

    1. Take the bus from Frederick Transit Center to BWI Amtrak Stationbus bus
    2. Take the train from BWI Thurgood Marshall to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    18h 37m
    $251–950

  9. Bus

    1. Take the bus from Frederick Bayrunner Office to Baltimore Downtown Bus Terminal, Baltimore, MDbus bus
    2. Take the bus from Baltimore Downtown Bus Station to New York Midtownbus bus
    3. Take the bus from New York to Knoxvillebus bus Nyc
    18h 56m
    $286–404

  10. Bus via Frederick Bus Station

    1. Take the bus from Frederick Bus Station to Baltimore Downtown Bus Stationbus bus
    2. Take the bus from Baltimore Downtown Bus Station to Port Authority Bus Terminalbus bus
    3. Take the bus from New York to Knoxvillebus bus Nyc
    19h 51m
    $314–472

Baltimore-Washington International Airport (BWI) to Mcghee Tyson Airport (TYS) flights

Calendar22Weekly Planes
Duration2h 58mAverage Duration
Ticket$125Cheapest Price
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Questions & Answers

Map of how to get from Frederick to Knoxville.ExpandLaunch map view
  • Distance: 525 mi
  • Duration: 3h 57m

What companies run services between Frederick, MD, USA and Knoxville, TN, USA?

You can take a bus from Frederick Bayrunner Office to Knoxville via Baltimore Downtown Bus Station, New York Midtown, 23 St, East Broadway, New York, and Knoxville in around 18h 56m.

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