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How to get fromFrederick to Panama Cityby train, plane, car, or bus

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There are 7 ways to get from Frederick to Panama City by train, plane, car, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train to Ronald Reagan Washington National Airport, fly to Northwest Florida Beaches International Airport

    best
    1. Take the train from FREDERICK MARC eb to ROCKVILLE MARC ebtrain train
    2. Fly from Ronald Reagan Washington National Airport (DCA) to Northwest Florida Beaches International Airport (ECP)plane plane DCA - ECP
    5h 55m
    $202–797

  2. Train to Ronald Reagan Washington National Airport, fly to Pensacola International Airport, drive

    cheapest
    1. Take the train from FREDERICK MARC eb to ROCKVILLE MARC ebtrain train
    2. Fly from Ronald Reagan Washington National Airport (DCA) to Pensacola International Airport (PNS)plane plane DCA - PNS
    3. Drive from Pensacola-Airport-PNS to Panama Citycar car
    7h 51m
    $146–696

  3. Drive 910.3 mi

    1. Drive from Frederick to Panama Citycar car 910.3 mi
    16h 47m
    $167–240

  4. Bus to Baltimore-Washington International Airport, fly to Destin–Fort Walton Beach Airport, drive

    1. Take the bus from Frederick Bayrunner Office to Baltimore Airportbus bus
    2. Fly from Baltimore-Washington International Airport (BWI) to Destin–Fort Walton Beach Airport (VPS)plane plane BWI - VPS
    3. Drive from Destin–Fort Walton Beach Airport (VPS) to Panama Citycar car
    5h 55m
    $176–584

  5. Bus to Washington Dulles International Airport, fly to Northwest Florida Beaches International Airport

    1. Take the bus from Frederick Transit Station to Market St & Harrison Stbus bus
    2. Fly from Washington Dulles International Airport (IAD) to Northwest Florida Beaches International Airport (ECP)plane plane IAD - ECP
    7h 34m
    $149–505

  6. Train to Ronald Reagan Washington National Airport, fly to Destin–Fort Walton Beach Airport, drive

    1. Take the train from FREDERICK MARC eb to ROCKVILLE MARC ebtrain train
    2. Fly from Ronald Reagan Washington National Airport (DCA) to Destin–Fort Walton Beach Airport (VPS)plane plane DCA - VPS
    3. Drive from Destin–Fort Walton Beach Airport (VPS) to Panama Citycar car
    7h 1m
    $149–735

  7. Train to Ronald Reagan Washington National Airport, fly to Tallahassee, drive

    1. Take the train from FREDERICK MARC eb to ROCKVILLE MARC ebtrain train
    2. Fly from Ronald Reagan Washington National Airport (DCA) to Tallahassee (TLH)plane plane DCA - TLH
    3. Drive from Tallahassee (TLH) to Panama Citycar car
    7h 6m
    $184–893

Ronald Reagan Washington National Airport (DCA) to Northwest Florida Beaches International Airport (ECP) flights

Calendar72Weekly Planes
Duration4h 28mAverage Duration
Ticket$135Cheapest Price
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Questions & Answers

Map of how to get from Frederick to Panama City.ExpandLaunch map view
  • Distance: 852.2 mi
  • Duration: 5h 55m

What companies run services between Frederick, MD, USA and Panama City, FL, USA?

There is no direct connection from Frederick to Panama City. However, you can take the train to ROCKVILLE MARC eb, walk to Rockville, Red Line Center Platform, take the subway to Farragut North, Red Line Center Platform, walk to Farragut West, Blue/Orange/Silver Line Track 2 Platform, take the subway to Ronald Reagan Washington National Airport, Yellow/Blue Line Track 2 Platform-Trains South Toward Alexandria, walk to Ronald Reagan Washington National Airport (DCA) airport, fly to Northwest Florida Beaches International Airport (ECP), then take the taxi to Panama City. Alternatively, you can drive from Frederick to Panama City in around 16h 47m.

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