There are 12 ways to get from Frederick to Syracuse by bus, train, car, plane, bus (Flixbus, Greyhound), bus (Greyhound), or train (Amtrak)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus, train
best- Take the bus from Frederick Transit Center to BWI Amtrak Stationbus
- Take the train from BWI Thurgood Marshall to Newark Penn Stationtrain
- Take the bus from Newark Penn Station to Syracuse Bus Stationbus
9h 51m$143–856Bus to Washington Dulles International Airport, fly to Ithaca Tompkins Regional Airport, bus
cheapest- Take the bus from Frederick Transit Station to Market St & Harrison Stbus
- Fly from Washington Dulles International Airport (IAD) to Ithaca Tompkins Regional Airport (ITH)plane IAD - ITH
- Take the bus from Ithaca to Syracuse Bus Stationbus
7h 57m$58–342Bus, train via New York
- Take the bus from Frederick Transit Center to BWI Amtrak Stationbus
- Take the train from BWI Thurgood Marshall to Ny Moynihan Train Hall At Penn Stationtrain
- Take the train from Ny Moynihan Train Hall At Penn Station to Syracuse Regional Transportation Centertrain
11h 39m$203–976Drive 320.3 mi
- Drive from Frederick to Syracusecar 320.3 mi
5h 59m$59–85Train to Ronald Reagan Washington National Airport, fly to Syracuse Hancock International Airport
- Take the train from FREDERICK MARC eb to ROCKVILLE MARC ebtrain
- Fly from Ronald Reagan Washington National Airport (DCA) to Syracuse Hancock International Airport (SYR)plane DCA - SYR
5h 58m$148–975Bus
- Take the bus from Frederick Bayrunner Office to Baltimore Downtown Bus Terminal, Baltimore, MDbus
- Take the bus from Baltimore Downtown Bus Station to Newark Penn Stationbus
- Take the bus from Newark Penn Station to Syracuse Bus Stationbus
10h 40m$129–212Bus via New York
- Take the bus from Frederick Bus Station to Baltimore Downtown Bus Stationbus
- Take the bus from Baltimore Downtown Bus Station to Port Authority Bus Terminalbus
- Take the bus from Port Authority Bus Terminal to Syracuse Bus Stationbus
11h 32m$172–379Train
- Take the train from FREDERICK MARC eb to Washington Union Stationtrain
- Take the train from Washington Union Station to Ny Moynihan Train Hall At Penn Stationtrain
- Take the train from Ny Moynihan Train Hall At Penn Station to Albany-Rensselaer Amtrak Stationtrain
- Take the train from Albany-Rensselaer Amtrak Station to Syracuse Regional Transportation Centertrain
12h 11m$157–447Bus to Washington Dulles International Airport, fly to Syracuse Hancock International Airport
- Take the bus from Frederick Transit Station to Market St & Harrison Stbus
- Fly from Washington Dulles International Airport (IAD) to Syracuse Hancock International Airport (SYR)plane IAD - SYR
6h 12m$90–633Bus to Baltimore-Washington International Airport, fly to Rochester, train
- Take the bus from Frederick Bayrunner Office to Baltimore Airportbus
- Fly from Baltimore-Washington International Airport (BWI) to Rochester (ROC)plane BWI - ROC
- Take the train from Rochester to Syracuse Regional Transportation Centertrain
5h 39m$198–868Bus to Washington Dulles International Airport, fly to Rochester, train
- Take the bus from Frederick Transit Station to Market St & Harrison Stbus
- Fly from Washington Dulles International Airport (IAD) to Rochester (ROC)plane IAD - ROC
- Take the train from Rochester to Syracuse Regional Transportation Centertrain
6h 51m$118–707Bus, train to Philadelphia International Airport, fly to Syracuse Hancock International Airport
- Take the bus from Frederick Transit Center to BWI Amtrak Stationbus
- Take the train from BWI Thurgood Marshall to 30th Street Stationtrain
- Fly from Philadelphia International Airport (PHL) to Syracuse Hancock International Airport (SYR)plane PHL - SYR
7h 43m$206–1,498
Frederick to Syracuse by bus and train
Questions & Answers
The cheapest way to get from Frederick to Syracuse is to drive which costs $55 - $85 and takes 5h 59m.
The fastest way to get from Frederick to Syracuse is to bus and fly and train which takes 5h 39m and costs $190 - $900.
No, there is no direct bus from Frederick to Syracuse station. However, there are services departing from Frederick Bayrunner Office and arriving at Syracuse Bus Station via Baltimore Downtown Bus Station and Newark Penn Station. The journey, including transfers, takes approximately 10h 40m.
No, there is no direct train from Frederick to Syracuse. However, there are services departing from FREDERICK MARC eb and arriving at Syracuse Regional Transportation Center via Washington Union Station, Ny Moynihan Train Hall At Penn Station and Albany-Rensselaer Amtrak Station. The journey, including transfers, takes approximately 12h 11m.
The distance between Frederick and Syracuse is 475 miles. The road distance is 322.1 miles.
The best way to get from Frederick to Syracuse without a car is to bus and train which takes 9h 51m and costs $140 - $900.
It takes approximately 9h 51m to get from Frederick to Syracuse, including transfers.
Frederick to Syracuse bus services, operated by BayRunner Shuttle, depart from Frederick Bayrunner Office station.
Frederick to Syracuse train services, operated by Maryland Transit, depart from FREDERICK MARC eb station.
The best way to get from Frederick to Syracuse is to bus which takes 10h 40m and costs $120 - $220. Alternatively, you can train, which costs $150 - $450 and takes 12h 11m.
What companies run services between Frederick, MD, USA and Syracuse, NY, USA?
You can take a bus from Frederick Bayrunner Office to Syracuse Bus Station via Baltimore Downtown Bus Station and Newark Penn Station in around 10h 40m. Alternatively, you can take a train from FREDERICK MARC eb to Syracuse Regional Transportation Center via Washington Union Station, Ny Moynihan Train Hall At Penn Station, and Albany-Rensselaer Amtrak Station in around 12h 11m.
- Website
- united.com
Flights from Washington Dulles International Airport to Syracuse Hancock International Airport
- Ave. Duration
- 1h 27m
- When
- Every day
- Estimated price
- $85–600
Flights from Washington Dulles International Airport to Rochester
- Ave. Duration
- 1h 27m
- When
- Every day
- Estimated price
- $75–500
Flights from Washington Dulles International Airport to Ithaca Tompkins Regional Airport
- Ave. Duration
- 1h 20m
- When
- Every day
- Estimated price
- $45–300
- Website
- southwest.com
Flights from Baltimore-Washington International Airport to Rochester
- Ave. Duration
- 1h 17m
- When
- Every day
- Estimated price
- $90–600
- Website
- aa.com
Flights from Ronald Reagan Washington National Airport to Syracuse Hancock International Airport
- Ave. Duration
- 1h 29m
- When
- Every day
- Estimated price
- $140–950
Flights from Philadelphia International Airport to Syracuse Hancock International Airport
- Ave. Duration
- 1h 23m
- When
- Every day
- Estimated price
- $110–750
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from BWI Thurgood Marshall to Newark Penn Station
- Ave. Duration
- 3h 14m
- Frequency
- Hourly
- Estimated price
- $55–130
- Website
- https://www.amtrak.com/home.html
Train from BWI Thurgood Marshall to Ny Moynihan Train Hall At Penn Station
- Ave. Duration
- 3h 39m
- Frequency
- Hourly
- Estimated price
- $60–130
- Website
- https://www.amtrak.com/home.html
Train from Ny Moynihan Train Hall At Penn Station to Syracuse Regional Transportation Center
- Ave. Duration
- 5h 39m
- Frequency
- 4 times a day
- Estimated price
- $90–190
- Website
- https://www.amtrak.com/home.html
Train from Washington Union Station to Ny Moynihan Train Hall At Penn Station
- Ave. Duration
- 4h 7m
- Frequency
- Hourly
- Estimated price
- $70–150
- Website
- https://www.amtrak.com/home.html
Train from Ny Moynihan Train Hall At Penn Station to Albany-Rensselaer Amtrak Station
- Ave. Duration
- 2h 31m
- Frequency
- Hourly
- Estimated price
- $45–95
- Website
- https://www.amtrak.com/home.html
Train from Albany-Rensselaer Amtrak Station to Syracuse Regional Transportation Center
- Ave. Duration
- 2h 46m
- Frequency
- 5 times a day
- Estimated price
- $45–100
- Website
- https://www.amtrak.com/home.html
Train from Rochester to Syracuse Regional Transportation Center
- Ave. Duration
- 1h 15m
- Frequency
- 5 times a day
- Estimated price
- $25–55
- Website
- https://www.amtrak.com/home.html
Train from Rochester to Syracuse Regional Transportation Center
- Ave. Duration
- 1h 15m
- Frequency
- 5 times a day
- Estimated price
- $25–55
- Website
- https://www.amtrak.com/home.html
Train from BWI Thurgood Marshall to 30th Street Station
- Ave. Duration
- 1h 39m
- Frequency
- Hourly
- Estimated price
- $30–70
- Website
- https://www.amtrak.com/home.html
Rome2Rio's guide to Amtrak Acela
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from BWI Thurgood Marshall to Newark Penn Station
- Ave. Duration
- 2h 20m
- Frequency
- Every 4 hours
- Estimated price
- $40–700
- Schedules at
- https://www.amtrak.com/acela-train
- Website
- https://www.amtrak.com/home.html
- Business Class
- $40–480
- First Class
- $180–700
Train from BWI Thurgood Marshall to Ny Moynihan Train Hall At Penn Station
- Ave. Duration
- 2h 43m
- Frequency
- Every 4 hours
- Estimated price
- $45–700
- Schedules at
- https://www.amtrak.com/acela-train
- Website
- https://www.amtrak.com/home.html
- Business Class
- $45–480
- First Class
- $180–700
Train from Washington Union Station to Ny Moynihan Train Hall At Penn Station
- Ave. Duration
- 3h
- Frequency
- Hourly
- Estimated price
- $50–750
- Schedules at
- https://www.amtrak.com/acela-train
- Website
- https://www.amtrak.com/home.html
- Business Class
- $50–490
- First Class
- $200–750
Train from BWI Thurgood Marshall to 30th Street Station
- Ave. Duration
- 1h 20m
- Frequency
- Every 4 hours
- Estimated price
- $24–650
- Schedules at
- https://www.amtrak.com/acela-train
- Website
- https://www.amtrak.com/home.html
- Business Class
- $24–460
- First Class
- $140–650
- Phone
- 1-866-743-3682
- Website
- mta.maryland.gov
Train from FREDERICK MARC eb to ROCKVILLE MARC eb
- Ave. Duration
- 58 min
- Frequency
- Twice daily
- Estimated price
- $2–10
- Website
- https://www.mta.maryland.gov
- Standard Fare
- $2–10
Train from FREDERICK MARC eb to Washington Union Station
- Ave. Duration
- 1h 40m
- Frequency
- Twice daily
- Estimated price
- $2–12
- Website
- https://www.mta.maryland.gov
- Standard Fare
- $2–12
- Phone
- +1 888 842-7245
- Website
- viarail.ca
Train from Albany-Rensselaer Amtrak Station to Syracuse Regional Transportation Center
- Ave. Duration
- 2h 39m
- Frequency
- Once daily
- Estimated price
- $40–190
- Website
- https://www.viarail.ca/en
- Escape
- $40–110
- Business
- $70–180
- Business Plus
- $85–190
- Economy
- $45–120
- Economy Plus
- $50–130
Train from Rochester to Syracuse Regional Transportation Center
- Ave. Duration
- 1h 15m
- Frequency
- Once daily
- Estimated price
- $21–160
- Website
- https://www.viarail.ca/en
- Escape
- $21–75
- Business
- $50–150
- Business Plus
- $65–160
- Economy
- $24–80
- Economy Plus
- $26–85
Train from Rochester to Syracuse Regional Transportation Center
- Ave. Duration
- 1h 15m
- Frequency
- Once daily
- Estimated price
- $21–160
- Website
- https://www.viarail.ca/en
- Escape
- $21–75
- Business
- $50–150
- Business Plus
- $65–160
- Economy
- $24–80
- Economy Plus
- $26–85
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Bus from Frederick Transit Center to BWI Amtrak Station
- Ave. Duration
- 55 min
- Frequency
- 4 times a day
- Estimated price
- $15–22
- Website
- https://www.amtrak.com/home.html
Bus from Frederick Transit Center to BWI Amtrak Station
- Ave. Duration
- 55 min
- Frequency
- 4 times a day
- Estimated price
- $15–22
- Website
- https://www.amtrak.com/home.html
Bus from Frederick Transit Center to BWI Amtrak Station
- Ave. Duration
- 55 min
- Frequency
- 4 times a day
- Estimated price
- $15–22
- Website
- https://www.amtrak.com/home.html
- Phone
- +1 410-912-6000
- [email protected]
- Website
- bayrunnershuttle.com
Bus from Frederick Transit Center to BWI Amtrak Station
- Ave. Duration
- 1h 10m
- Frequency
- 4 times a day
- Estimated price
- $65–90
- Schedules at
- bayrunnershuttle.com
Bus from Frederick Transit Center to BWI Amtrak Station
- Ave. Duration
- 1h 10m
- Frequency
- 4 times a day
- Estimated price
- $65–90
- Schedules at
- bayrunnershuttle.com
Bus from Frederick Bayrunner Office to Baltimore Downtown Bus Terminal, Baltimore, MD
- Ave. Duration
- 50 min
- Frequency
- Twice daily
- Estimated price
- $65–90
- Schedules at
- bayrunnershuttle.com
Bus from Frederick Bus Station to Baltimore Downtown Bus Station
- Ave. Duration
- 1h 5m
- Frequency
- Twice daily
- Estimated price
- $86–89
- Schedules at
- bayrunnershuttle.com
Bus from Frederick Bayrunner Office to Baltimore Airport
- Ave. Duration
- 1h
- Frequency
- 4 times a day
- Estimated price
- $65–90
- Schedules at
- bayrunnershuttle.com
Bus from Frederick Transit Center to BWI Amtrak Station
- Ave. Duration
- 1h 10m
- Frequency
- 4 times a day
- Estimated price
- $65–90
- Schedules at
- bayrunnershuttle.com
- Phone
- +1 (855) 626-8585
- Website
- https://www.flixbus.com
Bus from Newark Penn Station to Syracuse Bus Station
- Ave. Duration
- 4h 30m
- Frequency
- Every 2 hours
- Estimated price
- $35–65
- Schedules at
- flixbus.com
Bus from Baltimore Downtown Bus Station to Newark Penn Station
- Ave. Duration
- 3h 50m
- Frequency
- Every 3 hours
- Estimated price
- $28–50
- Schedules at
- flixbus.com
Bus from Newark Penn Station to Syracuse Bus Station
- Ave. Duration
- 4h 30m
- Frequency
- Every 2 hours
- Estimated price
- $35–65
- Schedules at
- flixbus.com
Bus from Ithaca to Syracuse Bus Station
- Ave. Duration
- 1h 15m
- Frequency
- 6 times a week
- Estimated price
- $9–17
- Schedules at
- flixbus.com
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- greyhound.com
Bus from Newark Penn Station to Syracuse Bus Station
- Ave. Duration
- 4h 30m
- Frequency
- 4 times a day
- Estimated price
- $35–70
- Website
- https://www.greyhound.com/
Bus from Baltimore Downtown Bus Station to Newark Penn Station
- Ave. Duration
- 3h 10m
- Frequency
- Every 4 hours
- Estimated price
- $26–55
- Website
- https://www.greyhound.com/
Bus from Newark Penn Station to Syracuse Bus Station
- Ave. Duration
- 4h 30m
- Frequency
- 4 times a day
- Estimated price
- $35–70
- Website
- https://www.greyhound.com/
Bus from Frederick Bus Station to Baltimore Downtown Bus Station
- Ave. Duration
- 2h 20m
- Frequency
- Every 4 hours
- Estimated price
- $12–23
- Website
- https://www.greyhound.com/
Bus from Baltimore Downtown Bus Station to Port Authority Bus Terminal
- Ave. Duration
- 3h 20m
- Frequency
- Hourly
- Estimated price
- $35–70
- Website
- https://www.greyhound.com/
Bus from Port Authority Bus Terminal to Syracuse Bus Station
- Ave. Duration
- 4h 45m
- Frequency
- Every 2 hours
- Estimated price
- $35–75
- Website
- https://www.greyhound.com/
- Phone
- 1-800-343-9999
- Website
- peterpanbus.com
Bus from Baltimore Downtown Bus Station to Port Authority Bus Terminal
- Ave. Duration
- 3h 44m
- Frequency
- Every 2 hours
- Estimated price
- $45–130
- Website
- https://peterpanbus.com
- Phone
- +1 800-858-8555
- Website
- trailways.com
Bus from Port Authority Bus Terminal to Syracuse Bus Station
- Ave. Duration
- 5h
- Frequency
- 4 times a day
- Estimated price
- $40–160
- Website
- https://trailways.com
- Schedules at
- https://trailways.com/schedules/
- Saver
- $40–150
- Flexible
- $70–160
- Phone
- +1 703-771-5665
- Website
- loudoun.gov
Bus from Frederick Transit Station to Market St & Harrison St
- Ave. Duration
- 58 min
- Frequency
- Once daily
- Estimated price
- $1–11
- Schedules at
- loudoun.gov
- Local & Metro
- $1–2
- Commuter
- $11
Bus from Frederick Transit Station to Market St & Harrison St
- Ave. Duration
- 58 min
- Frequency
- Once daily
- Estimated price
- $1–11
- Schedules at
- loudoun.gov
- Local & Metro
- $1–2
- Commuter
- $11
Bus from Frederick Transit Station to Market St & Harrison St
- Ave. Duration
- 58 min
- Frequency
- Once daily
- Estimated price
- $1–11
- Schedules at
- loudoun.gov
- Local & Metro
- $1–2
- Commuter
- $11
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Why you should take the train in the US
Read the travel guide
Need to know: Greyhound
Read the travel guide
More Questions & Answers
Frederick to Syracuse bus services, operated by BayRunner Shuttle, arrive at Baltimore Downtown Bus Terminal, Baltimore, MD station.
Frederick to Syracuse train services, operated by Maryland Transit, arrive at Washington Union Station.
Yes, the driving distance between Frederick to Syracuse is 322 miles. It takes approximately 5h 59m to drive from Frederick to Syracuse.
Book your Frederick to Syracuse bus tickets online with Omio.
There are 115+ hotels available in Syracuse.



























