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How to get fromFrederick to Winston-Salemby train, plane, bus, bus (Greyhound), or car

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There are 8 ways to get from Frederick to Winston-Salem by train, plane, bus, bus (Greyhound), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train to Ronald Reagan Washington National Airport, fly to Piedmont Triad International Airport

    best
    1. Take the train from FREDERICK MARC eb to ROCKVILLE MARC ebtrain train
    2. Fly from Ronald Reagan Washington National Airport (DCA) to Piedmont Triad International Airport (GSO)plane plane DCA - GSO
    5h 21m
    $146–890

  2. Drive 327.6 mi

    cheapest
    1. Drive from Frederick to Winston-Salemcar car 327.6 mi
    6h 13m
    $60–87

  3. Train, bus

    1. Take the train from FREDERICK MARC eb to Washington Union Stationtrain train
    2. Take the train from Washington Union Station to Greensborotrain train
    3. Take the bus from Greensboro Bus Stop to Winston Salem(Trans Center)bus bus
    10h 5m
    $96–211

  4. Bus (Greyhound)

    1. Take the bus from Frederick Bus Station to Washington Union Stationbus bus Greyhound US0164 / ...
    2. Take the bus from Washington Union Station to Winston Salem(Trans Center)bus bus Greyhound US0670
    10h 45m
    $62–123

  5. Bus to Washington Dulles International Airport, fly to Piedmont Triad International Airport

    1. Take the bus from Frederick Transit Station to Market St & Harrison Stbus bus
    2. Fly from Washington Dulles International Airport (IAD) to Piedmont Triad International Airport (GSO)plane plane IAD - GSO
    5h 30m
    $93–528

  6. Bus to Baltimore-Washington International Airport, fly to Raleigh-Durham International Airport, bus

    1. Take the bus from Frederick Bayrunner Office to Baltimore Airportbus bus
    2. Fly from Baltimore-Washington International Airport (BWI) to Raleigh-Durham International Airport (RDU)plane plane BWI - RDU
    3. Take the bus from Durham to Winston Salem(Trans Center)bus bus
    7h 15m
    $267–506

  7. Bus to Washington Dulles International Airport, fly to Charlotte Douglas International Airport, bus

    1. Take the bus from Frederick Transit Station to Market St & Harrison Stbus bus
    2. Fly from Washington Dulles International Airport (IAD) to Charlotte Douglas International Airport (CLT)plane plane IAD - CLT
    3. Take the bus from Charlotte Bus Station to Winston Salem(Trans Center)bus bus
    7h 46m
    $135–371

  8. Train, bus via Fredericksburg

    1. Take the train from FREDERICK MARC eb to Washington Union Stationtrain train
    2. Take the bus from Washington Union Station to Fredericksburgbus bus
    3. Take the bus from Fredericksburg to Greensboro Bus Stopbus bus
    14h 36m
    $66–118

Frederick to Winston-Salem by train and bus

Calendar14Weekly Services
Duration10h 5mAverage Duration
Ticket$96Cheapest Price
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Questions & Answers

Map of how to get from Frederick to Winston-Salem.ExpandLaunch map view
  • Distance: 330.6 mi
  • Duration: 5h 21m

What companies run services between Frederick, MD, USA and Winston-Salem, NC, USA?

You can take a bus from Frederick Bus Station to Winston Salem(Trans Center) via Washington Union Station in around 10h 45m.

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