There are 7 ways to get from Fresno to Santa Ana by bus, train, car, plane, or bus (Flixbus, Greyhound)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus, train (Amtrak)
best- Take the bus from Fresno to Los Angelesbus Amtrak Thruway Connecting Service
- Take the train from Los Angeles to Santa Anatrain Pacific Surfliner
6h 30m$61–97Bus
cheapest- Take the bus from Fresno Bus Station to Santa Ana Bus Stopbus FlixBus 2006
7h 5m$35–65Drive 251.1 mi
- Drive from Fresno to Santa Anacar 251.1 mi
4h 12m$46–67Fly Fresno Yosemite International Airport to John Wayne Airport Orange County
- Fly from Fresno Yosemite International Airport (FAT) to John Wayne Airport Orange County (SNA)plane FAT - SNA
5h 21m$400–836Fly Fresno Yosemite International Airport to Los Angeles International Airport, train
- Fly from Fresno Yosemite International Airport (FAT) to Los Angeles International Airport (LAX)plane FAT - LAX
- Take the train from Los Angeles to Santa Anatrain
5h 42m$406–685Fly Fresno Yosemite International Airport to San Diego International Airport, train
- Fly from Fresno Yosemite International Airport (FAT) to San Diego International Airport (SAN)plane FAT - SAN
- Take the train from San Diego to Santa Anatrain
6h 32m$105–311Bus to Norman Y. Mineta San José International Airport, fly to John Wayne Airport Orange County
- Take the bus from Fresno, CA to San Jose - King Rd Pink Elephantbus
- Fly from Norman Y. Mineta San José International Airport (SJC) to John Wayne Airport Orange County (SNA)plane SJC - SNA
6h 40m$245–877
Fresno to Santa Ana by bus and train (Amtrak)
Comparing Your Travel Options
The cheapest way to get from Fresno to Santa Ana is to bus which costs $35 - $65 and takes 7h 5m.
The fastest way to get from Fresno to Santa Ana is to drive which takes 4h 12m and costs $45 - $70.
Yes, there is a direct bus departing from Fresno Bus Station station and arriving at Santa Ana Bus Stop. Services depart twice daily, and operate every day. The journey takes approximately 7h 5m.
The distance between Fresno and Santa Ana is 267 miles. The road distance is 252.6 miles.
The best way to get from Fresno to Santa Ana without a car is to bus and train which takes 6h 30m and costs $60 - $100.
It takes approximately 6h 30m to get from Fresno to Santa Ana, including transfers.
Fresno to Santa Ana bus services, operated by Flixbus USA, depart from Fresno Bus Station.
The best way to get from Fresno to Santa Ana is to fly which takes 5h 21m and costs $400 - $850. Alternatively, you can bus, which costs $35 - $65 and takes 7h 5m.
Fresno to Santa Ana bus services, operated by Flixbus USA, arrive at Santa Ana Bus Stop station.
Yes, the driving distance between Fresno to Santa Ana is 253 miles. It takes approximately 4h 12m to drive from Fresno to Santa Ana.
What companies run services between Fresno, CA, USA and Santa Ana, CA, USA?
Southwest Airlines, United Airlines, and three other airlines fly from Fresno Yosemite International Airport (FAT) to John Wayne Airport Orange County (SNA) hourly. Alternatively, Flixbus USA operates a bus from Fresno Bus Station to Santa Ana Bus Stop once daily. Tickets cost $35–60 and the journey takes 7h 5m. Greyhound USA also services this route once daily.
- Website
- southwest.com
Flights from Fresno Yosemite International Airport to John Wayne Airport Orange County via Las Vegas
- Ave. Duration
- 4h 2m
- When
- Every day
- Estimated price
- $55–330
Flights from Fresno Yosemite International Airport to John Wayne Airport Orange County via Denver
- Ave. Duration
- 6h 50m
- When
- Monday to Wednesday
- Estimated price
- $120–550
Flights from Fresno Yosemite International Airport to San Diego International Airport
- Ave. Duration
- 1h 21m
- When
- Every day
- Estimated price
- $35–240
Flights from Norman Y. Mineta San José International Airport to John Wayne Airport Orange County
- Ave. Duration
- 1h 23m
- When
- Every day
- Estimated price
- $50–330
Flights from Norman Y. Mineta San José International Airport to John Wayne Airport Orange County via Las Vegas
- Ave. Duration
- 3h 35m
- When
- Monday, Thursday, and Friday
- Estimated price
- $65–390
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Los Angeles to Santa Ana
- Ave. Duration
- 50 min
- Frequency
- Hourly
- Estimated price
- $8–21
- Website
- Amtrak
Train from Los Angeles to Santa Ana
- Ave. Duration
- 50 min
- Frequency
- Hourly
- Estimated price
- $8–21
- Website
- Amtrak
Train from San Diego to Santa Ana
- Ave. Duration
- 2h 1m
- Frequency
- Hourly
- Estimated price
- $22–55
- Website
- Amtrak
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Bus from Fresno to Los Angeles
- Ave. Duration
- 4h 45m
- Frequency
- Once daily
- Estimated price
- $50–80
- Website
- Amtrak
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Booking & Getting There
Book your Fresno to Santa Ana bus tickets online with Omio and FlixBus.
There are 1606+ hotels available in Santa Ana.





