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How to get fromGainesville to Charlestonby bus, plane, bus (Greyhound), train (Amtrak), car, or train

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There are 7 ways to get from Gainesville to Charleston by bus, plane, bus (Greyhound), train (Amtrak), car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus, fly to Charleston International Airport

    best
    1. Take the bus from Gainesville to Atlanta Bus Stationbus bus
    2. Fly from Hartsfield-Jackson Atlanta International Airport (ATL) to Charleston International Airport (CHS)plane plane ATL - CHS
    5h 12m
    $354–1,034

  2. Drive 277.7 mi

    cheapest
    1. Drive from Gainesville to Charlestoncar car 277.7 mi
    6h 2m
    $51–74

  3. Bus via Charlotte (Greyhound)

    1. Take the bus from Gainesville to Charlotte Bus Stationbus bus Greyhound US0670
    2. Take the bus from Charlotte Bus Station to Charleston Bus Stationbus bus Greyhound US0643S
    12h 40m
    $84–162

  4. Train (Amtrak)

    1. Take the train from Gainesville Station to Charlotte Amtrak Stationtrain train
    2. Take the train from Charlotte Amtrak Station to Selma Stationtrain train
    3. Take the train from Selma Station to Charleston Amtrak Stationtrain train
    15h 14m
    $224–465

  5. Bus, fly to Hilton Head Airport, drive

    1. Take the bus from Gainesville to Atlanta Bus Stationbus bus
    2. Fly from Hartsfield-Jackson Atlanta International Airport (ATL) to Hilton Head Airport (HHH)plane plane ATL - HHH
    3. Drive from Hilton Head Airport (HHH) to Charlestoncar car
    6h 1m
    $90–409

  6. Train, bus

    1. Take the train from Gainesville Station to Charlotte Amtrak Stationtrain train Crescent
    2. Take the bus from Charlotte Bus Station to Charleston Bus Stationbus bus Greyhound US0643S
    14h 15m
    $112–230

  7. Bus

    1. Take the bus from BB Wireless - Gainesville to Atlantabus bus Charlotte
    2. Take the bus from Atlanta Bus Station to Charleston Bus Stationbus bus Greyhound US0641S
    15h 51m
    $117–289

Gainesville to Charleston by train, foot, tram, and bus

Calendar7Weekly Services
Duration14h 15mAverage Duration
Ticket$112Cheapest Price
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Questions & Answers

Map of how to get from Gainesville to Charleston.ExpandLaunch map view
  • Distance: 338.6 mi
  • Duration: 5h 12m

What companies run services between Gainesville, GA, USA and Charleston, SC, USA?

You can take a vehicle from Gainesville to Transit Mall via Gainesville, Charlotte Bus Station, Charleston Bus Station, North Charleston Transit Center, N. Charleston SuperStop, and Rivers Ave / Cosgrove Ave in around 12h 40m. Alternatively, you can take a train from Gainesville Station to Charleston via Charlotte Amtrak Station, Selma Station, and Charleston Amtrak Station in around 15h 14m.

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