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How to get fromGainesville to Chicagoby bus, plane, bus (Greyhound, Flixbus), train (Amtrak), car, train, or bus (Flixbus)

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There are 10 ways to get from Gainesville to Chicago by bus, plane, bus (Greyhound, Flixbus), train (Amtrak), car, train, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Hartsfield-Jackson Atlanta International Airport, fly to Chicago Midway International Airport

    best
    1. Take the bus from Gainesville to Atlanta Bus Stationbus bus
    2. Fly from Hartsfield-Jackson Atlanta International Airport (ATL) to Chicago Midway International Airport (MDW)plane plane ATL - MDW
    4h 59m
    $104–217

  2. Drive to Mcghee Tyson Airport, fly to Chicago O'Hare International Airport

    cheapest
    1. Drive from Gainesville to Mcghee Tyson Airport (TYS)car car
    2. Fly from Mcghee Tyson Airport (TYS) to Chicago O'Hare International Airport (ORD)plane plane TYS - ORD
    6h 16m
    $100–455

  3. Bus

    1. Take the bus from Gainesville to Atlanta Bus Stationbus bus Greyhound US0670
    2. Take the bus from Atlanta Bus Station to Chicago Bus Stationbus bus Greyhound US0100
    18h 8m
    $129–239

  4. Train (Amtrak)

    1. Take the train from Gainesville Station to Charlottesvilletrain train Crescent
    2. Take the train from Charlottesville to Chicago Union Stationtrain train Cardinal
    32h 23m
    $414–861

  5. Drive 662.8 mi

    1. Drive from Gainesville to Chicagocar car 662.8 mi
    13h 14m
    $121–175

  6. Bus to Hartsfield-Jackson Atlanta International Airport, fly to Chicago O'Hare International Airport

    1. Take the bus from Gainesville to Atlanta Bus Stationbus bus
    2. Fly from Hartsfield-Jackson Atlanta International Airport (ATL) to Chicago O'Hare International Airport (ORD)plane plane ATL - ORD
    5h 27m
    $214–397

  7. Bus to Greenville–Spartanburg International Airport, fly to Chicago O'Hare International Airport

    1. Take the bus from BB Wireless - Gainesville to Taqueria Guadalajara - Greenvillebus bus
    2. Fly from Greenville–Spartanburg International Airport (GSP) to Chicago O'Hare International Airport (ORD)plane plane GSP - ORD
    6h 46m
    $162–587

  8. Bus to Hartsfield-Jackson Atlanta International Airport, fly to South Bend, train

    1. Take the bus from Gainesville to Atlanta Bus Stationbus bus
    2. Fly from Hartsfield-Jackson Atlanta International Airport (ATL) to South Bend (SBN)plane plane ATL - SBN
    3. Take the train from South Bend Airport to Van Buren St.train train
    7h 22m
    $145–697

  9. Bus to Hartsfield-Jackson Atlanta International Airport, fly to General Mitchell International Airport, train

    1. Take the bus from Gainesville to Atlanta Bus Stationbus bus
    2. Fly from Hartsfield-Jackson Atlanta International Airport (ATL) to General Mitchell International Airport (MKE)plane plane ATL - MKE
    3. Take the train from Milwaukee to Chicago Union Stationtrain train
    7h 29m
    $171–756

  10. Bus via Bloomington

    1. Take the bus from BB Wireless - Gainesville to Atlantabus bus
    2. Take the bus from Atlanta Bus Station to Bloomingtonbus bus
    3. Take the bus from Bloomington to Chicago Bus Stationbus bus
    19h 7m
    $168–360

Gainesville to Chicago by train (Amtrak)

Calendar3Weekly Trains
Duration32h 23mAverage Duration
Ticket$414Cheapest Price
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Questions & Answers

Map of how to get from Gainesville to Chicago.ExpandLaunch map view
  • Distance: 666.5 mi
  • Duration: 4h 59m

What companies run services between Gainesville, GA, USA and Chicago, IL, USA?

You can take a vehicle from Gainesville to Chicago Bus Station via Gainesville and Atlanta Bus Station in around 18h 8m. Alternatively, you can take a train from Gainesville Station to Chicago Union Station via Charlottesville in around 32h 23m.

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