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How to get fromGainesville to Mount Pleasantby bus, plane, bus (Greyhound), train (Amtrak), or car

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There are 7 ways to get from Gainesville to Mount Pleasant by bus, plane, bus (Greyhound), train (Amtrak), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus, fly to Charleston International Airport, line 41 bus

    best
    1. Take the bus from Gainesville to Atlanta Bus Stationbus bus
    2. Fly from Hartsfield-Jackson Atlanta International Airport (ATL) to Charleston International Airport (CHS)plane plane ATL - CHS
    3. Take the bus from Mary St / Meeting St to Coleman Blvd / Chuck Dawley Blvdbus bus
    6h 36m
    $356–1,036

  2. Drive 280.7 mi

    cheapest
    1. Drive from Gainesville to Mount Pleasantcar car 280.7 mi
    6h 6m
    $52–74

  3. Bus via Charlotte (Greyhound)

    1. Take the bus from Gainesville to Charlotte Bus Stationbus bus Greyhound US0670
    2. Take the bus from Charlotte Bus Station to Charleston Bus Stationbus bus Greyhound US0643S
    13h 26m
    $86–164

  4. Train (Amtrak)

    1. Take the train from Gainesville Station to Charlotte Amtrak Stationtrain train
    2. Take the train from Charlotte Amtrak Station to Selma Stationtrain train
    3. Take the train from Selma Station to Charleston Amtrak Stationtrain train
    15h 18m
    $234–475

  5. Bus, fly to Hilton Head Airport, drive

    1. Take the bus from Gainesville to Atlanta Bus Stationbus bus
    2. Fly from Hartsfield-Jackson Atlanta International Airport (ATL) to Hilton Head Airport (HHH)plane plane ATL - HHH
    3. Drive from Hilton Head Airport (HHH) to Mount Pleasantcar car
    6h 8m
    $91–411

  6. Bus, fly to Greenville–Spartanburg International Airport, drive

    1. Take the bus from Gainesville to Atlanta Bus Stationbus bus
    2. Fly from Hartsfield-Jackson Atlanta International Airport (ATL) to Greenville–Spartanburg International Airport (GSP)plane plane ATL - GSP
    3. Drive from Greenville–Spartanburg International Airport (GSP) to Mount Pleasantcar car
    7h 8m
    $122–572

  7. Bus (Greyhound)

    1. Take the bus from Gainesville to Atlanta Bus Stationbus bus Greyhound US0670
    2. Take the bus from Atlanta Bus Station to Charleston Bus Stationbus bus Greyhound US0641S
    16h 22m
    $88–173

Hartsfield-Jackson Atlanta International Airport (ATL) to Charleston International Airport (CHS) flights

Calendar66Weekly Planes
Duration1h 15mAverage Duration
Ticket$57Cheapest Price
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Questions & Answers

Map of how to get from Gainesville to Mount Pleasant.ExpandLaunch map view
  • Distance: 346.3 mi
  • Duration: 6h 36m

What companies run services between Gainesville, GA, USA and Mount Pleasant, SC, USA?

You can take a vehicle from Gainesville to Houston Northcutt Blvd / Harbor Pointe Dr via Gainesville, Charlotte Bus Station, Charleston Bus Station, North Charleston Transit Center, N. Charleston SuperStop, Rivers Ave / Cosgrove Ave, and Mary St / Meeting St in around 13h 26m. Alternatively, you can take a train from Gainesville Station to Mount Pleasant via Charlotte Amtrak Station, Selma Station, and Charleston Amtrak Station in around 15h 18m.

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