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How to get fromGainesville to South Carolinaby bus, plane, bus (Greyhound), train (Amtrak), or car

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There are 7 ways to get from Gainesville to South Carolina by bus, plane, bus (Greyhound), train (Amtrak), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus, fly to Greenville–Spartanburg International Airport

    best
    1. Take the bus from Gainesville to Atlanta Bus Stationbus bus
    2. Fly from Hartsfield-Jackson Atlanta International Airport (ATL) to Greenville–Spartanburg International Airport (GSP)plane plane ATL - GSP
    3h 40m
    $122–557

  2. Drive 277.7 mi

    cheapest
    1. Drive from Gainesville to Charlestoncar car 277.7 mi
    6h 2m
    $51–74

  3. Bus via Charlotte (Greyhound)

    1. Take the bus from Gainesville to Charlotte Bus Stationbus bus Greyhound US0670
    2. Take the bus from Charlotte Bus Station to Charleston Bus Stationbus bus Greyhound US0643S
    13h 2m
    $84–162

  4. Train (Amtrak)

    1. Take the train from Gainesville Station to Charlotte Amtrak Stationtrain train
    2. Take the train from Charlotte Amtrak Station to Selma Stationtrain train
    3. Take the train from Selma Station to Charleston Amtrak Stationtrain train
    15h 14m
    $219–454

  5. Bus, fly to Charleston International Airport

    1. Take the bus from Gainesville to Atlanta Bus Stationbus bus
    2. Fly from Hartsfield-Jackson Atlanta International Airport (ATL) to Charleston International Airport (CHS)plane plane ATL - CHS
    4h 41m
    $354–1,034

  6. Bus, fly to Columbia

    1. Take the bus from Gainesville to Atlanta Bus Stationbus bus
    2. Fly from Hartsfield-Jackson Atlanta International Airport (ATL) to Columbia (CAE)plane plane ATL - CAE
    4h 50m
    $69–374

  7. Bus

    1. Take the bus from BB Wireless - Gainesville to Atlantabus bus Charlotte
    2. Take the bus from Atlanta Bus Station to Charleston Bus Stationbus bus Greyhound US0641S
    16h 13m
    $117–289

Hartsfield-Jackson Atlanta International Airport (ATL) to Greenville–Spartanburg International Airport (GSP) flights

Calendar52Weekly Planes
Duration58 minAverage Duration
Ticket$65Cheapest Price
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Questions & Answers

Map of how to get from Gainesville to South Carolina.ExpandLaunch map view
  • Distance: 230.4 mi
  • Duration: 3h 40m

What companies run services between Gainesville, GA, USA and South Carolina, USA?

You can take a vehicle from Gainesville to Broad St / Meeting St via Gainesville, Charlotte Bus Station, Charleston Bus Station, North Charleston Transit Center, N. Charleston SuperStop, Rivers Ave / Cosgrove Ave, Transit Mall, and Visitors Center on John St in around 13h 2m. Alternatively, you can take a train from Gainesville Station to Charleston via Charlotte Amtrak Station, Selma Station, and Charleston Amtrak Station in around 15h 14m.

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