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How to get fromGainesville to Chicagoby bus, plane, bus (Greyhound), train, car, or train (Amtrak)

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There are 10 ways to get from Gainesville to Chicago by bus, plane, bus (Greyhound), train, car, or train (Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Ronald Reagan Washington National Airport, fly to Chicago Midway International Airport

    best
    1. Take the bus from Heathcote Blvd @ Trek Way to Wilson Blvd @ N Kent Stbus bus
    2. Fly from Ronald Reagan Washington National Airport (DCA) to Chicago Midway International Airport (MDW)plane plane DCA - MDW
    4h 47m
    $125–619

  2. Bus to Baltimore-Washington International Airport, fly to Chicago O'Hare International Airport

    cheapest
    1. Take the bus from Heathcote Blvd @ Trek Way to N Fairfax Dr @ N Lincoln Stbus bus
    2. Fly from Baltimore-Washington International Airport (BWI) to Chicago O'Hare International Airport (ORD)plane plane BWI - ORD
    6h 15m
    $82–387

  3. Bus

    1. Take the bus from Heathcote Blvd @ Trek Way to Wilson Blvd @ N Kent Stbus bus 622
    2. Take the bus from Washington Union Station to Chicago Bus Stationbus bus Greyhound US0164
    19h 36m
    $116–227

  4. Bus, train

    1. Take the bus from Heathcote Blvd @ Trek Way to N Fairfax Dr @ N Lincoln Stbus bus 622
    2. Take the train from Rockville Amtrak to Chicago Union Stationtrain train Floridian
    19h 49m
    $255–517

  5. Drive 667.4 mi

    1. Drive from Gainesville to Chicagocar car 667.4 mi
    11h 51m
    $122–176

  6. Bus to Ronald Reagan Washington National Airport, fly to Chicago O'Hare International Airport

    1. Take the bus from Heathcote Blvd @ Trek Way to Wilson Blvd @ N Kent Stbus bus
    2. Fly from Ronald Reagan Washington National Airport (DCA) to Chicago O'Hare International Airport (ORD)plane plane DCA - ORD
    5h 10m
    $135–869

  7. Bus to Washington Dulles International Airport, fly to Chicago O'Hare International Airport

    1. Take the bus from Heathcote Blvd @ Trek Way to N Fairfax Dr @ N Lincoln Stbus bus
    2. Fly from Washington Dulles International Airport (IAD) to Chicago O'Hare International Airport (ORD)plane plane IAD - ORD
    5h 23m
    $195–919

  8. Bus to Baltimore-Washington International Airport, fly to Chicago Midway International Airport

    1. Take the bus from Heathcote Blvd @ Trek Way to N Fairfax Dr @ N Lincoln Stbus bus
    2. Fly from Baltimore-Washington International Airport (BWI) to Chicago Midway International Airport (MDW)plane plane BWI - MDW
    5h 47m
    $137–327

  9. Bus to Washington Dulles International Airport, fly to South Bend, train

    1. Take the bus from Heathcote Blvd @ Trek Way to N Fairfax Dr @ N Lincoln Stbus bus
    2. Fly from Washington Dulles International Airport (IAD) to South Bend (SBN)plane plane IAD - SBN
    3. Take the train from South Bend Airport to Van Buren St.train train
    7h 9m
    $136–1,229

  10. Train (Amtrak)

    1. Take the train from Manassas Amtrak Station to Chicago Union Stationtrain train Cardinal
    23h 7m
    $304–628

Gainesville to Chicago by bus and subway

Calendar14Weekly Services
Duration19h 36mAverage Duration
Ticket$116Cheapest Price
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Questions & Answers

Map of how to get from Gainesville to Chicago.ExpandLaunch map view
  • Distance: 646.2 mi
  • Duration: 4h 47m

What companies run services between Gainesville, VA, USA and Chicago, IL, USA?

You can take a bus from Heathcote Blvd @ Trek Way to Chicago Bus Station via Wilson Blvd @ N Kent St, Rosslyn, Blue/Orange/Silver Line Track 1 Platform, Foggy Bottom-GWU, Blue/Orange/Silver Line Center Platform, New Hampshire Av NW+24 St NW, Massachusetts Av NE+1 St NE, and Washington Union Station in around 19h 36m. Alternatively, Amtrak operates a train from Manassas Amtrak Station to Chicago Union Station 3 times a week. Tickets cost $280–600 and the journey takes 22h 53m.

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