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How to get fromGainesville to Big Pine Keyby bus, shuttle, car, plane, train, or bus (Flixbus, Greyhound)

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There are 9 ways to get from Gainesville to Big Pine Key by bus, shuttle, car, plane, train, or bus (Flixbus, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus, shuttle

    best
    1. Take the bus from University of Florida - 1956 Gale Lemerand Dr to Miami Airportbus bus Tallahassee
    2. Take a shuttle bus from Miami, FL - International Airport to Big Pine Key, FLshuttle bus To the Keys
    10h 35m
    $237–342

  2. Fly Gainesville Regional Airport to Key West International Airport, bus

    cheapest
    1. Fly from Gainesville Regional Airport (GNV) to Key West International Airport (EYW)plane plane GNV - EYW
    2. Take the bus from Key West Airport to Big Pine Keybus bus
    6h 25m
    $50–280

  3. Drive 445.3 mi

    1. Drive from Gainesville to Big Pine Keycar car 445.3 mi
    8h 39m
    $82–118

  4. Bus, train via Meadow Woods

    1. Take the bus from University of Florida - 1956 Gale Lemerand Dr to Orlando - RedCoach Station, FLbus bus
    2. Take the train from Orlando to Miamitrain train
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    11h 52m
    $110–289

  5. Bus, train

    1. Take the bus from University of Florida - 1956 Gale Lemerand Dr to West Palm Beach, FLbus bus
    2. Take the train from West Palm Beach Station to Miami Airport Stationtrain train
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    12h 11m
    $94–180

  6. Bus

    1. Take the bus from Gainesville to Miami Airport Stationbus bus FlixBus N2401 / ...
    2. Take the bus from Miami Airport Station to Big Pine Keybus bus Greyhound US0720s
    12h 55m
    $77–133

  7. Fly Gainesville Regional Airport to Miami International Airport, shuttle

    1. Fly from Gainesville Regional Airport (GNV) to Miami International Airport (MIA)plane plane GNV - MIA
    2. Take a shuttle bus from Miami, FL - International Airport to Big Pine Key, FLshuttle bus
    6h 34m
    $196–472

  8. Bus to Orlando, fly to Key West International Airport, bus

    1. Take the bus from University of Florida - 1956 Gale Lemerand Dr to Orlando - RedCoach Station, FLbus bus
    2. Fly from Orlando (MCO) to Key West International Airport (EYW)plane plane MCO - EYW
    3. Take the bus from Key West Airport to Big Pine Keybus bus
    6h 20m
    $100–715

  9. Drive to Orlando Sanford, fly to Key West International Airport, bus

    1. Drive from Gainesville to Orlando-Sanford-Airport-SFBcar car
    2. Fly from Orlando Sanford (SFB) to Key West International Airport (EYW)plane plane SFB - EYW
    3. Take the bus from Key West Airport to Big Pine Keybus bus
    5h 21m
    $59–288

Gainesville to Big Pine Key by bus and shuttle

Calendar21Weekly Services
Duration10h 35mAverage Duration
Ticket$237Cheapest Price
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Questions & Answers

Map of how to get from Gainesville to Big Pine Key.ExpandLaunch map view
  • Distance: 478.3 mi
  • Duration: 10h 35m

What companies run services between Gainesville, FL, USA and Big Pine Key, FL, USA?

You can take a bus from Gainesville to Big Pine Key via Miami Airport Station in around 12h 55m.

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Train operators
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