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How to get fromGainesville to Buffaloby plane, bus (Flixbus, Greyhound), bus, train, or car

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There are 9 ways to get from Gainesville to Buffalo by plane, bus (Flixbus, Greyhound), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Gainesville Regional Airport to Buffalo Niagara International Airport

    best
    1. Fly from Gainesville Regional Airport (GNV) to Buffalo Niagara International Airport (BUF)plane plane GNV - BUF
    7h 7m
    $134–730

  2. Bus

    1. Take the bus from Gainesville to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to Cleveland Bus Stationbus bus
    3. Take the bus from Cleveland Bus Station to Buffalobus bus
    29h 45m
    $198–369

  3. Bus, train via New York

    1. Take the bus from Gainesville to Jacksonvillebus bus
    2. Take the train from Jacksonville to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the train from Ny Moynihan Train Hall At Penn Station to Buffalotrain train
    31h 35m
    $431–949

  4. Drive 1,097.3 mi

    1. Drive from Gainesville to Buffalocar car 1,097.3 mi
    18h 45m
    $201–290

  5. Bus to Orlando, fly to Buffalo Niagara International Airport

    1. Take the bus from University of Florida - 1956 Gale Lemerand Dr to Orlando - RedCoach Station, FLbus bus
    2. Fly from Orlando (MCO) to Buffalo Niagara International Airport (BUF)plane plane MCO - BUF
    6h 55m
    $184–386

  6. Bus to Jacksonville, fly to Buffalo Niagara International Airport

    1. Take the bus from Gainesville to Jacksonvillebus bus
    2. Fly from Jacksonville (JAX) to Buffalo Niagara International Airport (BUF)plane plane JAX - BUF
    8h 58m
    $153–798

  7. Bus to Tampa, fly to Buffalo Niagara International Airport

    1. Take the bus from Gainesville to Tampa Bus Stationbus bus
    2. Fly from Tampa (TPA) to Buffalo Niagara International Airport (BUF)plane plane TPA - BUF
    7h 45m
    $223–713

  8. Fly Gainesville Regional Airport to Rochester, bus

    1. Fly from Gainesville Regional Airport (GNV) to Rochester (ROC)plane plane GNV - ROC
    2. Take the bus from Rochester Bus Stop to Buffalobus bus
    8h 40m
    $180–844

  9. Bus, train

    1. Take the bus from Gainesville to Jacksonvillebus bus
    2. Take the train from Jacksonville to Pittsburgh Amtrak Stationtrain train
    3. Take the bus from Pittsburgh, Pa to Buffalo, Nybus bus 510
    37h 18m
    $376–909

Gainesville to Buffalo by bus

Calendar7Weekly Buses
Duration29h 45mAverage Duration
Ticket$198Cheapest Price
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Questions & Answers

Map of how to get from Gainesville to Buffalo.ExpandLaunch map view
  • Distance: 955.2 mi
  • Duration: 7h 7m

What companies run services between Gainesville, FL, USA and Buffalo, NY, USA?

American Airlines and Delta fly from Gainesville Regional Airport (GNV) to Buffalo Niagara International Airport (BUF) every 4 hours. Alternatively, you can take a bus from Gainesville to Buffalo via Atlanta Bus Station and Cleveland Bus Station in around 29h 45m.

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