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How to get fromGainesville to Chicagoby plane, bus (Flixbus, Greyhound), bus, train, or car

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There are 9 ways to get from Gainesville to Chicago by plane, bus (Flixbus, Greyhound), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Gainesville Regional Airport to Chicago Midway International Airport

    best
    1. Fly from Gainesville Regional Airport (GNV) to Chicago Midway International Airport (MDW)plane plane GNV - MDW
    6h 32m
    $88–426

  2. Fly Gainesville Regional Airport to Chicago O'Hare International Airport

    cheapest
    1. Fly from Gainesville Regional Airport (GNV) to Chicago O'Hare International Airport (ORD)plane plane GNV - ORD
    6h 41m
    $74–366

  3. Bus

    1. Take the bus from Gainesville to Atlanta Bus Stationbus bus FlixBus N2467 / ...
    2. Take the bus from Atlanta Bus Station to Chicago Bus Stationbus bus Greyhound US0100
    22h 50m
    $149–289

  4. Bus, train

    1. Take the bus from Gainesville to Jacksonvillebus bus FlixBus 2431
    2. Take the train from Jacksonville to Chicago Union Stationtrain train Floridian
    38h 33m
    $481–1,019

  5. Drive 999.1 mi

    1. Drive from Gainesville to Chicagocar car 999.1 mi
    18h
    $183–264

  6. Bus to Jacksonville, fly to Chicago Midway International Airport

    1. Take the bus from Gainesville to Jacksonvillebus bus
    2. Fly from Jacksonville (JAX) to Chicago Midway International Airport (MDW)plane plane JAX - MDW
    7h
    $143–464

  7. Bus to Jacksonville, fly to Chicago O'Hare International Airport

    1. Take the bus from Gainesville to Jacksonvillebus bus
    2. Fly from Jacksonville (JAX) to Chicago O'Hare International Airport (ORD)plane plane JAX - ORD
    7h 32m
    $193–524

  8. Bus to Orlando, fly to Chicago Midway International Airport

    1. Take the bus from University of Florida - 1956 Gale Lemerand Dr to Orlando - RedCoach Station, FLbus bus
    2. Fly from Orlando (MCO) to Chicago Midway International Airport (MDW)plane plane MCO - MDW
    6h 52m
    $234–552

  9. Bus to Tampa, fly to Chicago Midway International Airport

    1. Take the bus from Gainesville to Tampa Bus Stationbus bus
    2. Fly from Tampa (TPA) to Chicago Midway International Airport (MDW)plane plane TPA - MDW
    7h 32m
    $153–439

Gainesville to Chicago by bus

Calendar27Weekly Buses
Duration22h 50mAverage Duration
Ticket$149Cheapest Price
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Questions & Answers

Map of how to get from Gainesville to Chicago.ExpandLaunch map view
  • Distance: 906 mi
  • Duration: 6h 32m

What companies run services between Gainesville, FL, USA and Chicago, IL, USA?

Delta, American Airlines, and Southwest Airlines fly from Gainesville Regional Airport (GNV) to Chicago Midway International Airport (MDW) 3 times a day. Alternatively, you can take a bus from Gainesville to Chicago Bus Station via Atlanta Bus Station in around 22h 50m.

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