There are 7 ways to get from Gainesville to Des Moines by plane, bus (Flixbus, Greyhound), bus, train, or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly from Gainesville Regional Airport
best- Fly from Gainesville Regional Airport (GNV) to Des Moines (DSM)plane GNV - DSM
6h 41m$168–772Bus
- Take the bus from Gainesville to Atlanta Bus Stationbus
- Take the bus from Atlanta Bus Station to St Louis Bus Stationbus
- Take the bus from St Louis Bus Station to Des Moinesbus
28h$176–355Bus, train
- Take the bus from Gainesville to Jacksonvillebus
- Take the train from Jacksonville to Chicago Union Stationtrain
- Take the bus from Chicago Bus Station to Des Moinesbus
46h 12m$486–1,058Drive 1,211.8 mi
- Drive from Gainesville to Des Moinescar 1,211.8 mi
21h 13m$222–320Bus to Jacksonville, fly
- Take the bus from Gainesville to Jacksonvillebus
- Fly from Jacksonville (JAX) to Des Moines (DSM)plane JAX - DSM
8h 46m$178–789Bus to Valdosta, fly
- Take the bus from Gainesville to Valdostabus
- Fly from Valdosta (VLD) to Des Moines (DSM)plane VLD - DSM
8h 32m$185–762Drive to Orlando Sanford, fly
- Drive from Gainesville to Orlando-Sanford-Airport-SFBcar
- Fly from Orlando Sanford (SFB) to Des Moines (DSM)plane SFB - DSM
5h 30m$197–800
Gainesville to Des Moines by bus
Questions & Answers
The cheapest way to get from Gainesville to Des Moines is to bus which costs $170 - $360 and takes 28h.
The fastest way to get from Gainesville to Des Moines is to drive and fly which takes 5h 30m and costs $190 - $800.
No, there is no direct bus from Gainesville to Des Moines. However, there are services departing from Gainesville and arriving at Des Moines via Atlanta Bus Station and St Louis Bus Station. The journey, including transfers, takes approximately 28h.
The distance between Gainesville and Des Moines is 1054 miles. The road distance is 1218.8 miles.
The best way to get from Gainesville to Des Moines without a car is to bus which takes 28h and costs $170 - $360.
It takes approximately 6h 41m to get from Gainesville to Des Moines, including transfers.
Gainesville to Des Moines bus services, operated by Flixbus USA, depart from Gainesville station.
The best way to get from Gainesville to Des Moines is to fly which takes 6h 41m and costs $160 - $800. Alternatively, you can bus, which costs $170 - $360 and takes 28h.
Gainesville to Des Moines bus services, operated by Flixbus USA, arrive at Atlanta Bus Station.
Des Moines is 1h behind Gainesville. It is currently 9:22 PM in Gainesville and 8:22 PM in Des Moines.
What companies run services between Gainesville, FL, USA and Des Moines, IA, USA?
Delta and American Airlines fly from Gainesville Regional Airport (GNV) to Des Moines (DSM) 4 times a day. Alternatively, you can take a bus from Gainesville to Des Moines via Atlanta Bus Station and St Louis Bus Station in around 28h.
- Website
- delta.com
Flights from Gainesville Regional Airport to Des Moines via Atlanta
- Ave. Duration
- 5h 39m
- When
- Every day
- Estimated price
- $150–750
Flights from Jacksonville to Des Moines via Atlanta
- Ave. Duration
- 4h 55m
- When
- Every day
- Estimated price
- $150–750
Flights from Jacksonville to Des Moines via Detroit
- Ave. Duration
- 5h 59m
- When
- Every day
- Estimated price
- $190–850
Flights from Jacksonville to Des Moines via Minneapolis
- Ave. Duration
- 7h 32m
- When
- Every day
- Estimated price
- $200–900
Flights from Valdosta to Des Moines via Atlanta
- Ave. Duration
- 7h 12m
- When
- Every day
- Estimated price
- $140–700
- Website
- aa.com
Flights from Gainesville Regional Airport to Des Moines via Dallas/Ft.Worth
- Ave. Duration
- 8h 10m
- When
- Every day
- Estimated price
- $200–900
Flights from Gainesville Regional Airport to Des Moines via Charlotte
- Ave. Duration
- 7h 5m
- When
- Thursday and Sunday
- Estimated price
- $170–800
Flights from Jacksonville to Des Moines via Charlotte
- Ave. Duration
- 5h 39m
- When
- Every day
- Estimated price
- $170–800
Flights from Jacksonville to Des Moines via Chicago O'Hare
- Ave. Duration
- 7h
- When
- Every day
- Estimated price
- $170–800
- Website
- united.com
Flights from Jacksonville to Des Moines via Chicago O'Hare
- Ave. Duration
- 5h 58m
- When
- Every day
- Estimated price
- $170–800
- Website
- southwest.com
Flights from Jacksonville to Des Moines via Chicago Midway
- Ave. Duration
- 5h 28m
- When
- Saturday, Monday, Thursday, Friday, and Sunday
- Estimated price
- $170–800
- Website
- allegiantair.com
Flights from Orlando Sanford to Des Moines
- Ave. Duration
- 2h 54m
- When
- Friday, Monday, and Wednesday
- Estimated price
- $160–750
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Jacksonville to Chicago Union Station
- Ave. Duration
- 35h 12m
- Frequency
- Once daily
- Estimated price
- $430–950
- Website
- Amtrak
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Gainesville to Atlanta Bus Station
- Ave. Duration
- 5h 50m
- Frequency
- 4 times a day
- Estimated price
- $45–75
- Schedules at
- Flixbus USA
Bus from Atlanta Bus Station to St Louis Bus Station
- Ave. Duration
- 10h 21m
- Frequency
- 5 times a week
- Estimated price
- $75–130
- Schedules at
- Flixbus USA
Bus from Gainesville to Jacksonville
- Ave. Duration
- 1h 30m
- Frequency
- 6 times a week
- Estimated price
- $9–16
- Schedules at
- Flixbus USA
Bus from Gainesville to Jacksonville
- Ave. Duration
- 1h 30m
- Frequency
- 6 times a week
- Estimated price
- $9–16
- Schedules at
- Flixbus USA
Bus from Gainesville to Valdosta
- Ave. Duration
- 2h 5m
- Frequency
- 4 times a day
- Estimated price
- $14–24
- Schedules at
- Flixbus USA
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Atlanta Bus Station to St Louis Bus Station
- Ave. Duration
- 11h 40m
- Frequency
- Once daily
- Estimated price
- $80–160
- Website
- Greyhound
Bus from St Louis Bus Station to Des Moines
- Ave. Duration
- 8h 30m
- Frequency
- 4 times a week
- Estimated price
- $55–120
- Website
- Greyhound
Bus from Chicago Bus Station to Des Moines
- Ave. Duration
- 6h 30m
- Frequency
- 3 times a day
- Estimated price
- $45–90
- Website
- Greyhound
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More Questions & Answers
Yes, the driving distance between Gainesville to Des Moines is 1219 miles. It takes approximately 21h 13m to drive from Gainesville to Des Moines.
Book your Gainesville to Des Moines bus tickets online with Omio and FlixBus.
There are 262+ hotels available in Des Moines.






