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How to get fromGainesville to Des Moinesby plane, bus (Flixbus, Greyhound), bus, train, or car

Find Transport to Des Moines

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There are 8 ways to get from Gainesville to Des Moines by plane, bus (Flixbus, Greyhound), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Gainesville Regional Airport

    best
    1. Fly from Gainesville Regional Airport (GNV) to Des Moines (DSM)plane plane GNV - DSM
    6h 45m
    $114–492

  2. Bus

    1. Take the bus from Gainesville to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to Indianapolis Union Stationbus bus
    3. Take the bus from Indianapolis Union Station to Des Moinesbus bus
    29h 35m
    $200–334

  3. Bus, train

    1. Take the bus from Gainesville to Jacksonvillebus bus
    2. Take the train from Jacksonville to Chicago Union Stationtrain train
    3. Take the bus from Chicago Bus Station to Des Moinesbus bus
    46h 12m
    $461–1,003

  4. Drive  1,211.8 mi

    1. Drive from Gainesville to Des Moinescar car 1,211.8 mi
    21h 13m
    $222–320

  5. Bus to Jacksonville, fly

    1. Take the bus from Gainesville to Jacksonvillebus bus
    2. Fly from Jacksonville (JAX) to Des Moines (DSM)plane plane JAX - DSM
    8h 51m
    $118–479

  6. Drive to Orlando Sanford, fly

    1. Drive from Gainesville to Orlando-Sanford-Airport-SFBcar car
    2. Fly from Orlando Sanford (SFB) to Des Moines (DSM)plane plane SFB - DSM
    5h 31m
    $137–540

  7. Bus to Valdosta, fly

    1. Take the bus from Gainesville to Valdostabus bus
    2. Fly from Valdosta (VLD) to Des Moines (DSM)plane plane VLD - DSM
    8h 36m
    $136–512

  8. Bus, train via Atlanta

    1. Take the bus from Gainesville to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to St Louis Bus Stationbus bus
    3. Take the train from St. Louis to Kansas Citytrain train
    4. Take the bus from Kansas City Bus Station to Des Moinesbus bus
    30h 7m
    $235–424

Gainesville to Des Moines by bus

Calendar7Weekly Buses
Duration29h 35mAverage Duration
Ticket$200Cheapest Price
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Comparing Your Travel Options

Map of how to get from Gainesville to Des Moines.ExpandLaunch map view
  • Distance: 1,047.8 mi
  • Duration: 6h 45m

What companies run services between Gainesville, FL, USA and Des Moines, IA, USA?

Delta and American Airlines fly from Gainesville Regional Airport (GNV) to Des Moines (DSM) every 4 hours. Alternatively, you can take a bus from Gainesville to Des Moines via Atlanta Bus Station and Indianapolis Union Station in around 29h 35m.

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