Rome2Rio

How to get fromGainesville to Florenceby bus (Flixbus), bus, train, car, plane, or bus (Flixbus, Greyhound)

Find Transport to Florence

See all options

There are 6 ways to get from Gainesville to Florence by bus (Flixbus), bus, train, car, plane, or bus (Flixbus, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Gainesville to Jacksonvillebus bus FlixBus 2431
    2. Take the bus from Jacksonville to Florence Bus Stationbus bus FlixBus 2433
    7h 40m

  2. Bus via Sumter

    cheapest
    1. Take the bus from Gainesville to Jacksonvillebus bus
    2. Take the bus from Jacksonville to Sumter Bus Stopbus bus
    3. Take the bus from Sumter Bus Stop to Florence Bus Stationbus bus
    10h 35m
    $62–126

  3. Bus, train

    1. Take the bus from Gainesville to Jacksonvillebus bus FlixBus 2431
    2. Take the train from Jacksonville to Florence Stationtrain train Silver Meteor
    9h 32m
    $122–252

  4. Drive 370.9 mi

    1. Drive from Gainesville to Florencecar car 370.9 mi
    6h 20m
    $68–98

  5. Fly to Florence Regional Airport

    1. Fly from Gainesville Regional Airport (GNV) to Florence Regional Airport (FLO)plane plane GNV - FLO
    5h 40m
    $72–354

  6. Fly to Myrtle Beach, bus

    1. Fly from Gainesville Regional Airport (GNV) to Myrtle Beach (MYR)plane plane GNV - MYR
    2. Take the bus from Myrtle Beach to Florencebus bus
    7h 26m

Gainesville Regional Airport (GNV) to Florence Regional Airport (FLO) flights

Calendar35Weekly Planes
Duration6h 51mAverage Duration
Ticket$61Cheapest Price
See schedules

Questions & Answers

Map of how to get from Gainesville to Florence.ExpandLaunch map view
  • Distance: 380.9 mi
  • Duration: 7h 40m

What companies run services between Gainesville, FL, USA and Florence, SC, USA?

You can take a bus from Gainesville to Florence Bus Station via Jacksonville in around 7h 40m. Alternatively, American Airlines flies from Gainesville Regional Airport (GNV) to Florence Regional Airport (FLO) 5 times a day.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers