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How to get fromGainesville to Florida Keysby bus, shuttle, car, plane, train, or bus (Flixbus, Greyhound)

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There are 9 ways to get from Gainesville to Florida Keys by bus, shuttle, car, plane, train, or bus (Flixbus, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus, shuttle

    best
    1. Take the bus from University of Florida - 1956 Gale Lemerand Dr to Miami Airportbus bus Tallahassee
    2. Take a shuttle bus from Miami, FL - International Airport to Summerland Key - Mote Marine Labshuttle bus To the Keys
    12h 17m
    $241–349

  2. Bus

    cheapest
    1. Take the bus from Gainesville to Miami Airport Stationbus bus FlixBus N2401 / ...
    2. Take the bus from Miami Airport Station to Big Pine Keybus bus Greyhound US0720s
    14h 25m
    $73–130

  3. Drive 459 mi

    1. Drive from Gainesville to Florida Keyscar car 459 mi
    8h 59m
    $84–121

  4. Fly Gainesville Regional Airport to Key West International Airport

    1. Fly from Gainesville Regional Airport (GNV) to Key West International Airport (EYW)plane plane GNV - EYW
    7h 36m
    $118–366

  5. Bus, train

    1. Take the bus from University of Florida - 1956 Gale Lemerand Dr to West Palm Beach, FLbus bus
    2. Take the train from West Palm Beach Station to Miami Airport Stationtrain train
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    13h 41m
    $95–186

  6. Bus, train via Tampa

    1. Take the bus from Gainesville to Tampa Bus Stationbus bus
    2. Take the train from Tampa to Delray Beach Amtraktrain train
    3. Take the train from Delray Beach Station to Miami Airport Stationtrain train
    4. Take the bus from Miami Airport Station to Big Pine Keybus bus
    15h 44m
    $108–228

  7. Fly Gainesville Regional Airport to Miami International Airport, shuttle

    1. Fly from Gainesville Regional Airport (GNV) to Miami International Airport (MIA)plane plane GNV - MIA
    2. Take a shuttle bus from Miami, FL - International Airport to Big Pine Key, FLshuttle bus
    8h 4m
    $198–496

  8. Bus to Orlando, fly to Key West International Airport

    1. Take the bus from University of Florida - 1956 Gale Lemerand Dr to Orlando - RedCoach Station, FLbus bus
    2. Fly from Orlando (MCO) to Key West International Airport (EYW)plane plane MCO - EYW
    7h 32m
    $179–801

  9. Bus to Tampa, fly to Key West International Airport

    1. Take the bus from Gainesville to Tampa Bus Stationbus bus
    2. Fly from Tampa (TPA) to Key West International Airport (EYW)plane plane TPA - EYW
    8h 25m
    $173–518

Gainesville to Florida Keys by bus, shuttle, and foot

Calendar21Weekly Services
Duration12h 17mAverage Duration
Ticket$241Cheapest Price
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Questions & Answers

Map of how to get from Gainesville to Florida Keys.ExpandLaunch map view
  • Distance: 491.4 mi
  • Duration: 12h 17m

What companies run services between Gainesville, FL, USA and Florida Keys, FL, USA?

American Airlines and Delta fly from Gainesville Regional Airport (GNV) to Key West International Airport (EYW) every 4 hours. Alternatively, you can take a bus from Gainesville to Florida Keys via Miami Airport Station, Big Pine Key, Big Pine Key - CVS / MM30, and Sugarloaf Key - Lower - Sugarloaf Lodge in around 14h 25m.

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