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How to get fromGainesville to Gatlinburgby plane, taxi, bus, car, or train

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There are 9 ways to get from Gainesville to Gatlinburg by plane, taxi, bus, car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Gainesville Regional Airport to Mcghee Tyson Airport, taxi

    best
    1. Fly from Gainesville Regional Airport (GNV) to Mcghee Tyson Airport (TYS)plane plane GNV - TYS
    2. Take the taxi from Mcghee Tyson Airport (TYS) to Gatlinburgtaxi taxi
    6h 3m
    $322–1,162

  2. Drive  505.2 mi

    cheapest
    1. Drive from Gainesville to Gatlinburgcar car 505.2 mi
    9h 50m
    $87–125

  3. Bus, drive

    1. Take the bus from Gainesville to Jacksonvillebus bus
    2. Take the bus from Jacksonville to Charlotte Bus Stationbus bus
    3. Take the bus from Charlotte Bus Station to Winston Salem(Trans Center)bus bus
    4. Take the bus from Winston Salem(Trans Center) to Asheville, NCbus bus
    5. Drive from New Leicester Hwy at Walgreens to Gatlinburgcar car
    18h 46m
    $124–207

  4. Bus, train, drive

    1. Take the bus from Gainesville to Jacksonvillebus bus
    2. Take the train from Jacksonville to Carytrain train
    3. Take the train from Cary to Greensborotrain train
    4. Take the bus from Greensboro Bus Stop to Asheville, NCbus bus
    5. Drive from Asheville, NC to Gatlinburgcar car
    21h 46m
    $355–564

  5. Drive to Orlando Sanford, fly to Mcghee Tyson Airport, taxi

    1. Drive from Gainesville to Orlando-Sanford-Airport-SFBcar car
    2. Fly from Orlando Sanford (SFB) to Mcghee Tyson Airport (TYS)plane plane SFB - TYS
    3. Take the taxi from Mcghee Tyson Airport (TYS) to Gatlinburgtaxi taxi
    5h 11m
    $349–1,238

  6. Bus to Jacksonville, fly to Mcghee Tyson Airport, taxi

    1. Take the bus from Gainesville to Jacksonvillebus bus
    2. Fly from Jacksonville (JAX) to Mcghee Tyson Airport (TYS)plane plane JAX - TYS
    3. Take the taxi from Mcghee Tyson Airport (TYS) to Gatlinburgtaxi taxi
    6h 33m
    $312–1,079

  7. Bus to Orlando, fly to Mcghee Tyson Airport, taxi

    1. Take the bus from University of Florida - 1956 Gale Lemerand Dr to Orlando - RedCoach Station, FLbus bus
    2. Fly from Orlando (MCO) to Mcghee Tyson Airport (TYS)plane plane MCO - TYS
    3. Take the taxi from Mcghee Tyson Airport (TYS) to Gatlinburgtaxi taxi
    6h 21m
    $361–1,201

  8. Drive to Orlando Sanford, fly to Asheville Regional Airport, drive

    1. Drive from Gainesville to Orlando-Sanford-Airport-SFBcar car
    2. Fly from Orlando Sanford (SFB) to Asheville Regional Airport (AVL)plane plane SFB - AVL
    3. Drive from Asheville-Airport-AVL to Gatlinburgcar car
    6h 3m
    $88–409

  9. Bus, drive via Atlanta

    1. Take the bus from Gainesville to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to Winston Salem(Trans Center)bus bus
    3. Take the bus from Winston Salem(Trans Center) to Asheville, NCbus bus
    4. Drive from Asheville, NC to Gatlinburgcar car
    18h 53m
    $148–229

Gainesville Regional Airport (GNV) to Mcghee Tyson Airport (TYS) flights

Calendar62Weekly Planes
Duration4h 40mAverage Duration
Ticket$157Cheapest Price
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Comparing Your Travel Options

Map of how to get from Gainesville to Gatlinburg.ExpandLaunch map view
  • Distance: 478.6 mi
  • Duration: 6h 3m

What companies run services between Gainesville, FL, USA and Gatlinburg, TN, USA?

There is no direct connection from Gainesville to Gatlinburg. However, you can take the line 25 bus to Airport, walk to Gainesville Regional Airport (GNV) airport, fly to Mcghee Tyson Airport (TYS), then take the taxi to Gatlinburg. Alternatively, you can take a bus from Gainesville to Gatlinburg via Jacksonville, Charlotte Bus Station, Winston Salem(Trans Center), Asheville, NC, ART Station, and New Leicester Hwy at Walgreens in around 18h 46m.

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