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How to get fromGainesville to Great Smoky Mountainsby plane, car, bus, or train

Find Transport to Great Smoky Mountains

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There are 9 ways to get from Gainesville to Great Smoky Mountains by plane, car, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Gainesville Regional Airport to Mcghee Tyson Airport, drive

    best
    1. Fly from Gainesville Regional Airport (GNV) to Mcghee Tyson Airport (TYS)plane plane GNV - TYS
    2. Drive from Mcghee Tyson Airport (TYS) to Great Smoky Mountainscar car
    6h 31m
    $112–618

  2. Drive to Orlando Sanford, fly to Asheville Regional Airport, drive

    cheapest
    1. Drive from Gainesville to Orlando-Sanford-Airport-SFBcar car
    2. Fly from Orlando Sanford (SFB) to Asheville Regional Airport (AVL)plane plane SFB - AVL
    3. Drive from Asheville-Airport-AVL to Great Smoky Mountainscar car
    6h 7m
    $89–391

  3. Bus, drive via Atlanta

    1. Take the bus from Gainesville to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to Winston Salem(Trans Center)bus bus
    3. Take the bus from Winston Salem(Trans Center) to Asheville, NCbus bus
    4. Drive from Asheville, NC to Great Smoky Mountainscar car
    18h 33m
    $132–247

  4. Bus, train, drive

    1. Take the bus from Gainesville to Jacksonvillebus bus
    2. Take the train from Jacksonville to Carytrain train
    3. Take the train from Cary to Greensborotrain train
    4. Take the bus from Greensboro Bus Stop to Asheville, NCbus bus
    5. Drive from Asheville, NC to Great Smoky Mountainscar car
    21h 51m
    $223–461

  5. Drive 495.8 mi

    1. Drive from Gainesville to Great Smoky Mountainscar car 495.8 mi
    9h 38m
    $91–131

  6. Drive to Orlando Sanford, fly to Mcghee Tyson Airport, drive

    1. Drive from Gainesville to Orlando-Sanford-Airport-SFBcar car
    2. Fly from Orlando Sanford (SFB) to Mcghee Tyson Airport (TYS)plane plane SFB - TYS
    3. Drive from Mcghee Tyson Airport (TYS) to Great Smoky Mountainscar car
    5h 54m
    $140–695

  7. Fly Gainesville Regional Airport to Hartsfield-Jackson Atlanta International Airport, drive

    1. Fly from Gainesville Regional Airport (GNV) to Hartsfield-Jackson Atlanta International Airport (ATL)plane plane GNV - ATL
    2. Drive from Atlanta-Airport-ATL to Great Smoky Mountainscar car
    6h 43m
    $96–456

  8. Bus to Orlando, fly to Mcghee Tyson Airport, drive

    1. Take the bus from University of Florida - 1956 Gale Lemerand Dr to Orlando - RedCoach Station, FLbus bus
    2. Fly from Orlando (MCO) to Mcghee Tyson Airport (TYS)plane plane MCO - TYS
    3. Drive from Mcghee Tyson Airport (TYS) to Great Smoky Mountainscar car
    6h 57m
    $141–673

  9. Bus, drive

    1. Take the bus from Gainesville to Jacksonvillebus bus
    2. Take the bus from Jacksonville to Charlotte Bus Stationbus bus
    3. Take the bus from Charlotte Bus Station to Winston Salem(Trans Center)bus bus
    4. Take the bus from Winston Salem(Trans Center) to Asheville, NCbus bus
    5. Drive from New Leicester Hwy at Walgreens to Great Smoky Mountainscar car
    18h 52m
    $108–233

Gainesville Regional Airport (GNV) to Mcghee Tyson Airport (TYS) flights

Calendar64Weekly Planes
Duration4h 34mAverage Duration
Ticket$103Cheapest Price
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Questions & Answers

Map of how to get from Gainesville to Great Smoky Mountains.ExpandLaunch map view
  • Distance: 498.6 mi
  • Duration: 6h 31m

What companies run services between Gainesville, FL, USA and Great Smoky Mountains, TN, USA?

There is no direct connection from Gainesville to Great Smoky Mountains. However, you can take the line 25 bus to Airport, walk to Gainesville Regional Airport (GNV) airport, fly to Mcghee Tyson Airport (TYS), then drive to Great Smoky Mountains. Alternatively, you can take a bus from Gainesville to Great Smoky Mountains via Atlanta Bus Station, Winston Salem(Trans Center), and Asheville, NC in around 18h 33m.

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