Rome2Rio

How to get fromGainesville to Knoxvilleby plane, bus, shuttle, car, or taxi

Find Transport to Knoxville

See all options

There are 7 ways to get from Gainesville to Knoxville by plane, bus, shuttle, car, or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Gainesville Regional Airport

    best
    1. Fly from Gainesville Regional Airport (GNV) to Mcghee Tyson Airport (TYS)plane plane GNV - TYS
    4h 57m
    $156–672

  2. Drive 527.9 mi

    cheapest
    1. Drive from Gainesville to Knoxvillecar car 527.9 mi
    9h 4m
    $97–140

  3. Bus, shuttle, drive

    1. Take the bus from Gainesville to Jacksonvillebus bus
    2. Take the bus from Jacksonville to Charlotte Bus Stationbus bus
    3. Take the bus from Charlotte to Boonebus bus
    4. Take a shuttle bus from Boone to Black Bear Resortshuttle bus
    5. Take a shuttle bus from Black Bear Resort to Hot Springsshuttle bus
    6. Drive from Hot Springs to Knoxvillecar car
    19h 4m

  4. Drive to Orlando Sanford, fly

    1. Drive from Gainesville to Orlando-Sanford-Airport-SFBcar car
    2. Fly from Orlando Sanford (SFB) to Mcghee Tyson Airport (TYS)plane plane SFB - TYS
    4h 19m
    $185–749

  5. Bus to Jacksonville, fly

    1. Take the bus from Gainesville to Jacksonvillebus bus
    2. Fly from Jacksonville (JAX) to Mcghee Tyson Airport (TYS)plane plane JAX - TYS
    5h 40m
    $177–791

  6. Bus to Orlando, fly

    1. Take the bus from University of Florida - 1956 Gale Lemerand Dr to Orlando - RedCoach Station, FLbus bus
    2. Fly from Orlando (MCO) to Mcghee Tyson Airport (TYS)plane plane MCO - TYS
    5h 22m
    $186–726

  7. Bus, taxi, shuttle, drive

    1. Take the bus from Gainesville to Jacksonvillebus bus
    2. Take the bus from Jacksonville to Camdenbus bus
    3. Take the bus from Camden to Charlotte Bus Stationbus bus
    4. Take the bus from Charlotte to Boonebus bus
    5. Take the taxi from Boone to Black Bear Resorttaxi taxi
    6. Take a shuttle bus from Black Bear Resort to Hot Springsshuttle bus
    7. Drive from Hot Springs to Chilhowee at Holstoncar car
    21h 53m

Gainesville Regional Airport (GNV) to Mcghee Tyson Airport (TYS) flights

Calendar64Weekly Planes
Duration4h 34mAverage Duration
Ticket$107Cheapest Price
See schedules

Questions & Answers

Map of how to get from Gainesville to Knoxville.ExpandLaunch map view
  • Distance: 452.2 mi
  • Duration: 4h 57m

What companies run services between Gainesville, FL, USA and Knoxville, TN, USA?

Delta and American Airlines fly from Gainesville Regional Airport (GNV) to Mcghee Tyson Airport (TYS) every 3 hours.

Airlines
Bus operators
Other operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound