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How to get fromGainesville to Knoxvilleby plane, bus, shuttle, car, or taxi

Find Transport to Knoxville

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There are 7 ways to get from Gainesville to Knoxville by plane, bus, shuttle, car, or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Gainesville Regional Airport

    best
    1. Fly from Gainesville Regional Airport (GNV) to Mcghee Tyson Airport (TYS)plane plane GNV - TYS
    4h 45m
    $176–872

  2. Drive  527.9 mi

    cheapest
    1. Drive from Gainesville to Knoxvillecar car 527.9 mi
    9h 4m
    $97–140

  3. Bus, shuttle, drive

    1. Take the bus from Gainesville to Jacksonvillebus bus
    2. Take the bus from Jacksonville to Charlotte Bus Stationbus bus
    3. Take the bus from Charlotte to Boonebus bus
    4. Take a shuttle bus from Boone to Black Bear Resortshuttle bus
    5. Take a shuttle bus from Black Bear Resort to Hot Springsshuttle bus
    6. Drive from Hot Springs to Knoxvillecar car
    19h 4m
    $317–376

  4. Drive to Orlando Sanford, fly

    1. Drive from Gainesville to Orlando-Sanford-Airport-SFBcar car
    2. Fly from Orlando Sanford (SFB) to Mcghee Tyson Airport (TYS)plane plane SFB - TYS
    4h 18m
    $205–899

  5. Bus to Jacksonville, fly

    1. Take the bus from Gainesville to Jacksonvillebus bus
    2. Fly from Jacksonville (JAX) to Mcghee Tyson Airport (TYS)plane plane JAX - TYS
    5h 42m
    $176–788

  6. Bus to Orlando, fly

    1. Take the bus from University of Florida - 1956 Gale Lemerand Dr to Orlando - RedCoach Station, FLbus bus
    2. Fly from Orlando (MCO) to Mcghee Tyson Airport (TYS)plane plane MCO - TYS
    5h 25m
    $216–911

  7. Bus, taxi, shuttle, drive

    1. Take the bus from Gainesville to Jacksonvillebus bus
    2. Take the bus from Jacksonville to Camdenbus bus
    3. Take the bus from Camden to Charlotte Bus Stationbus bus
    4. Take the bus from Charlotte to Boonebus bus
    5. Take the taxi from Boone to Black Bear Resorttaxi taxi
    6. Take a shuttle bus from Black Bear Resort to Hot Springsshuttle bus
    7. Drive from Hot Springs to Chilhowee at Holstoncar car
    21h 53m
    $359–451

Gainesville Regional Airport (GNV) to Mcghee Tyson Airport (TYS) flights

Calendar76Weekly Planes
Duration5h 2mAverage Duration
Ticket$126Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Gainesville to Knoxville.ExpandLaunch map view
  • Distance: 452.2 mi
  • Duration: 4h 45m

What companies run services between Gainesville, FL, USA and Knoxville, TN, USA?

Delta and American Airlines fly from Gainesville Regional Airport (GNV) to Mcghee Tyson Airport (TYS) every 2 hours.

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