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How to get fromGainesville to Louisvilleby plane, bus (Flixbus, Greyhound, Amtrak), car, bus, or bus (Greyhound)

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There are 8 ways to get from Gainesville to Louisville by plane, bus (Flixbus, Greyhound, Amtrak), car, bus, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Gainesville Regional Airport to Louisville International Airport

    best
    1. Fly from Gainesville Regional Airport (GNV) to Louisville International Airport (SDF)plane plane GNV - SDF
    6h 16m
    $98–554

  2. Bus via Atlanta

    1. Take the bus from Gainesville to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to Nashville Bus Stationbus bus
    3. Take the bus from Nashville to Louisville, KYbus bus
    15h 35m
    $117–210

  3. Drive 705.3 mi

    1. Drive from Gainesville to Louisvillecar car 705.3 mi
    13h
    $129–186

  4. Fly Gainesville Regional Airport to Blue Grass Airport, drive

    1. Fly from Gainesville Regional Airport (GNV) to Blue Grass Airport (LEX)plane plane GNV - LEX
    2. Drive from Lexington-Airport-LEX to Louisvillecar car
    5h 59m
    $154–770

  5. Bus to Orlando, fly to Louisville International Airport

    1. Take the bus from University of Florida - 1956 Gale Lemerand Dr to Orlando - RedCoach Station, FLbus bus
    2. Fly from Orlando (MCO) to Louisville International Airport (SDF)plane plane MCO - SDF
    6h 47m
    $302–859

  6. Bus to Jacksonville, fly to Louisville International Airport

    1. Take the bus from Gainesville to Jacksonvillebus bus
    2. Fly from Jacksonville (JAX) to Louisville International Airport (SDF)plane plane JAX - SDF
    8h 37m
    $293–624

  7. Bus to Tampa, fly to Louisville International Airport

    1. Take the bus from Gainesville to Tampa Bus Stationbus bus
    2. Fly from Tampa (TPA) to Louisville International Airport (SDF)plane plane TPA - SDF
    7h 52m
    $264–640

  8. Bus

    1. Take the bus from University of Florida - 1956 Gale Lemerand Dr to Tallahassee - FSU - Old St Augustine at Intramural Fieldbus bus
    2. Take the bus from Tallahassee to Nashville Bus Stationbus bus
    3. Take the bus from Tornado Bus Co - Nashville to La Tropicana - Louisville, KYbus bus
    20h
    $167–376

Gainesville to Louisville by bus

Calendar14Weekly Buses
Duration15h 35mAverage Duration
Ticket$117Cheapest Price
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Questions & Answers

Map of how to get from Gainesville to Louisville.ExpandLaunch map view
  • Distance: 630.9 mi
  • Duration: 6h 16m

What companies run services between Gainesville, FL, USA and Louisville, KY, USA?

Delta and American Airlines fly from Gainesville Regional Airport (GNV) to Louisville International Airport (SDF) every 3 hours. Alternatively, you can take a bus from Gainesville to Louisville, KY via Atlanta Bus Station and Nashville in around 15h 35m.

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