Rome2Rio

How to get fromGainesville to Mayo Clinicby plane, bus (Flixbus, Greyhound), bus, train, car, or bus (Greyhound)

Find Transport to Mayo Clinic

See all options

There are 11 ways to get from Gainesville to Mayo Clinic by plane, bus (Flixbus, Greyhound), bus, train, car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Gainesville Regional Airport to Rochester

    best
    1. Fly from Gainesville Regional Airport (GNV) to Rochester (RST)plane plane GNV - RST
    10h 25m
    $102–482

  2. Bus via Milwaukee

    1. Take the bus from Gainesville to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to Milwaukee Intermodal Stationbus bus
    4. Take the bus from Milwaukee to Rochesterbus bus
    30h 52m
    $248–434

  3. Bus, train via Madison

    1. Take the bus from Gainesville to Jacksonvillebus bus
    2. Take the train from Jacksonville to Chicago Union Stationtrain train
    3. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    4. Take the bus from Madison to Rochesterbus bus
    2d
    $587–1,251

  4. Drive 1,329.7 mi

    1. Drive from Gainesville to Mayo Cliniccar car 1,329.7 mi
    22h 49m
    $243–351

  5. Fly Gainesville Regional Airport to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Gainesville Regional Airport (GNV) to Minneapolis–Saint Paul International Airport (MSP)plane plane GNV - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    9h 17m
    $184–654

  6. Bus to Jacksonville, fly to Rochester

    1. Take the bus from Gainesville to Jacksonvillebus bus
    2. Fly from Jacksonville (JAX) to Rochester (RST)plane plane JAX - RST
    10h 58m
    $132–571

  7. Bus to Jacksonville, fly to Minneapolis–Saint Paul International Airport, bus

    1. Take the bus from Gainesville to Jacksonvillebus bus
    2. Fly from Jacksonville (JAX) to Minneapolis–Saint Paul International Airport (MSP)plane plane JAX - MSP
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    9h 52m
    $214–773

  8. Bus to Orlando, fly to Minneapolis–Saint Paul International Airport, bus

    1. Take the bus from University of Florida - 1956 Gale Lemerand Dr to Orlando - RedCoach Station, FLbus bus
    2. Fly from Orlando (MCO) to Minneapolis–Saint Paul International Airport (MSP)plane plane MCO - MSP
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    9h 44m
    $283–1,208

  9. Bus to Tampa, fly to Minneapolis–Saint Paul International Airport, bus

    1. Take the bus from Gainesville to Tampa Bus Stationbus bus
    2. Fly from Tampa (TPA) to Minneapolis–Saint Paul International Airport (MSP)plane plane TPA - MSP
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    10h 45m
    $225–790

  10. Bus

    1. Take the bus from Gainesville Bus Stop to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to Chicago Train Stationbus bus
    3. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    4. Take the bus from Madison to Rochesterbus bus
    35h 28m
    $236–452

  11. Bus, train

    1. Take the bus from Gainesville to Jacksonvillebus bus
    2. Take the train from Jacksonville to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train
    4. Take the bus from St. Paul to Rochester, MNbus bus
    2d 1h
    $670–1,431

Gainesville to Mayo Clinic by bus, train, and foot

Calendar4Weekly Services
Duration2d 1hAverage Duration
Ticket$670Cheapest Price
See schedules

Questions & Answers

Map of how to get from Gainesville to Mayo Clinic.ExpandLaunch map view
  • Distance: 1,146 mi
  • Duration: 10h 25m

What companies run services between Gainesville, FL, USA and Mayo Clinic, MN, USA?

Delta and American Airlines fly from Gainesville Regional Airport (GNV) to Rochester (RST) 5 times a day. Alternatively, you can take a bus from Gainesville to Mayo Clinic via Atlanta Bus Station, Chicago Bus Station, Milwaukee Intermodal Station, Milwaukee, and Rochester in around 30h 52m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers