There are 7 ways to get from Gainesville to North Charleston by bus, train, bus (Flixbus, Greyhound), car, or plane
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus, train
best- Take the bus from Gainesville to Jacksonvillebus FlixBus 2431
- Take the train from Jacksonville to Charleston Amtrak Stationtrain Silver Meteor
7h 35m$92–191Bus
cheapest- Take the bus from Gainesville to Jacksonvillebus
- Take the bus from Jacksonville to Savannah Bus Stationbus
- Take the bus from Savannah Bus Station to Charleston Bus Stationbus
7h 50m$50–98Drive 301.8 mi
- Drive from Gainesville to North Charlestoncar 301.8 mi
5h 25m$56–80Fly from Gainesville Regional Airport
- Fly from Gainesville Regional Airport (GNV) to Charleston International Airport (CHS)plane GNV - CHS
6h 13m$74–384Bus to Orlando, fly
- Take the bus from University of Florida - 1956 Gale Lemerand Dr to Orlando - RedCoach Station, FLbus
- Fly from Orlando (MCO) to Charleston International Airport (CHS)plane MCO - CHS
5h 56m$98–318Bus to Jacksonville, fly
- Take the bus from Gainesville to Jacksonvillebus
- Fly from Jacksonville (JAX) to Charleston International Airport (CHS)plane JAX - CHS
8h 16m$89–443Bus to Tampa, fly
- Take the bus from Gainesville to Tampa Bus Stationbus
- Fly from Tampa (TPA) to Charleston International Airport (CHS)plane TPA - CHS
7h 10m$165–360
Gainesville to North Charleston by bus and train
Questions & Answers
The cheapest way to get from Gainesville to North Charleston is to bus which costs $50 - $100 and takes 7h 50m.
The fastest way to get from Gainesville to North Charleston is to drive which takes 5h 25m and costs $55 - $80.
No, there is no direct bus from Gainesville to North Charleston station. However, there are services departing from Gainesville and arriving at Charleston Bus Station via Jacksonville and Savannah Bus Station. The journey, including transfers, takes approximately 7h 50m.
The distance between Gainesville and North Charleston is 326 miles. The road distance is 303.5 miles.
The best way to get from Gainesville to North Charleston without a car is to bus and train which takes 7h 35m and costs $90 - $200.
It takes approximately 7h 35m to get from Gainesville to North Charleston, including transfers.
Gainesville to North Charleston bus services, operated by Flixbus USA, depart from Gainesville station.
The best way to get from Gainesville to North Charleston is to bus which takes 7h 50m and costs $50 - $100. Alternatively, you can fly, which costs $70 - $390 and takes 6h 13m.
Gainesville to North Charleston bus services, operated by Flixbus USA, arrive at Jacksonville station.
Yes, the driving distance between Gainesville to North Charleston is 304 miles. It takes approximately 5h 25m to drive from Gainesville to North Charleston.
What companies run services between Gainesville, FL, USA and North Charleston, SC, USA?
You can take a bus from Gainesville to Charleston Bus Station via Jacksonville and Savannah Bus Station in around 7h 50m. Alternatively, American Airlines and Delta fly from Gainesville Regional Airport (GNV) to Charleston International Airport (CHS) every 3 hours.
- Website
- delta.com
Flights from Gainesville Regional Airport to Charleston International Airport via Atlanta
- Ave. Duration
- 5h 12m
- When
- Every day
- Estimated price
- $70–380
Flights from Jacksonville to Charleston International Airport via Atlanta
- Ave. Duration
- 4h 5m
- When
- Every day
- Estimated price
- $80–430
Flights from Tampa to Charleston International Airport via Atlanta
- Ave. Duration
- 3h 57m
- When
- Every day
- Estimated price
- $80–430
- Website
- aa.com
Flights from Gainesville Regional Airport to Charleston International Airport via Charlotte
- Ave. Duration
- 4h 15m
- When
- Every day
- Estimated price
- $70–380
Flights from Gainesville Regional Airport to Charleston International Airport via Dallas/Ft.Worth
- Ave. Duration
- 7h 38m
- When
- Every day
- Estimated price
- $170–700
Flights from Jacksonville to Charleston International Airport via Charlotte
- Ave. Duration
- 3h 56m
- When
- Every day
- Estimated price
- $75–420
Flights from Jacksonville to Charleston International Airport via Miami
- Ave. Duration
- 4h 29m
- When
- Every day
- Estimated price
- $100–550
Flights from Tampa to Charleston International Airport via Miami
- Ave. Duration
- 3h 57m
- When
- Tuesday
- Estimated price
- $85–430
- Website
- flybreeze.com
Flights from Orlando to Charleston International Airport
- Ave. Duration
- 1h 28m
- When
- Every day
- Estimated price
- $65–250
Flights from Jacksonville to Charleston International Airport via Norfolk
- Ave. Duration
- 5h 45m
- When
- Tuesday, Thursday, and Sunday
- Estimated price
- $210–1,200
Flights from Tampa to Charleston International Airport
- Ave. Duration
- 1h 32m
- When
- Every day
- Estimated price
- $140–320
- Website
- southwest.com
Flights from Jacksonville to Charleston International Airport via Nashville
- Ave. Duration
- 4h 57m
- When
- Tuesday to Friday
- Estimated price
- $110–550
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Jacksonville to Charleston Amtrak Station
- Ave. Duration
- 4h 14m
- Frequency
- Once daily
- Estimated price
- $80–170
- Website
- https://www.amtrak.com/home.html
- Phone
- +1 (855) 626-8585
- Website
- https://www.flixbus.com
Bus from Gainesville to Jacksonville
- Ave. Duration
- 1h 30m
- Frequency
- 4 times a week
- Estimated price
- $11–19
- Schedules at
- flixbus.com
Bus from Gainesville to Jacksonville
- Ave. Duration
- 1h 30m
- Frequency
- 4 times a week
- Estimated price
- $11–19
- Schedules at
- flixbus.com
Bus from Jacksonville to Savannah Bus Station
- Ave. Duration
- 2h 15m
- Frequency
- 5 times a day
- Estimated price
- $22–40
- Schedules at
- flixbus.com
Bus from Gainesville to Jacksonville
- Ave. Duration
- 1h 30m
- Frequency
- 4 times a week
- Estimated price
- $11–19
- Schedules at
- flixbus.com
Bus from Gainesville to Tampa Bus Station
- Ave. Duration
- 2h 35m
- Frequency
- Once daily
- Estimated price
- $21–35
- Schedules at
- flixbus.com
- Website
- flixbus.com
Bus from Jacksonville to Savannah Bus Station
- Ave. Duration
- 2h 15m
- Frequency
- 5 times a day
- Schedules at
- flixbus.com
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- greyhound.com
Bus from Jacksonville to Savannah Bus Station
- Ave. Duration
- 2h 20m
- Frequency
- Twice daily
- Estimated price
- $22–45
- Website
- https://www.greyhound.com/
Bus from Savannah Bus Station to Charleston Bus Station
- Ave. Duration
- 2h 10m
- Frequency
- 3 times a week
- Estimated price
- $17–35
- Website
- https://www.greyhound.com/
- Website
- greyhound.com
Bus from Jacksonville to Savannah Bus Station
- Ave. Duration
- 3h 5m
- Frequency
- Once daily
- Schedules at
- greyhound.com
- Phone
- +1 877 733 0724
- Website
- redcoachusa.com
Bus from University of Florida - 1956 Gale Lemerand Dr to Orlando - RedCoach Station, FL
- Ave. Duration
- 2h
- Frequency
- 4 times a day
- Estimated price
- $29–55
- Website
- https://www.redcoachusa.com
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Why you should take the train in the US
Read the travel guide
Need to know: Greyhound
Read the travel guide
More Questions & Answers
Book your Gainesville to North Charleston bus tickets online with Omio and FlixBus.
There are 1402+ hotels available in North Charleston.










