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How to get fromGainesville to Sioux Fallsby plane, bus (Flixbus, Greyhound), bus, train, or car

Find Transport to Sioux Falls

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There are 6 ways to get from Gainesville to Sioux Falls by plane, bus (Flixbus, Greyhound), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Gainesville Regional Airport

    best
    1. Fly from Gainesville Regional Airport (GNV) to Sioux Falls (FSD)plane plane GNV - FSD
    7h 23m
    $104–554

  2. Bus

    1. Take the bus from Gainesville to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to St Louis Bus Stationbus bus
    3. Take the bus from St Louis Bus Station to Kansas City Bus Stationbus bus
    4. Take the bus from Kansas City to Sioux Fallsbus bus
    34h 58m
    $261–420

  3. Bus, train

    1. Take the bus from Gainesville to Jacksonvillebus bus
    2. Take the train from Jacksonville to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Kansas Citytrain train
    4. Take the bus from Kansas City to Sioux Fallsbus bus
    2d 9h
    $629–1,325

  4. Drive  1,442.1 mi

    1. Drive from Gainesville to Sioux Fallscar car 1,442.1 mi
    25h 29m
    $264–381

  5. Bus to Valdosta, fly

    1. Take the bus from Gainesville to Valdostabus bus
    2. Fly from Valdosta (VLD) to Sioux Falls (FSD)plane plane VLD - FSD
    12h 7m
    $131–532

  6. Bus to Jacksonville, fly

    1. Take the bus from Gainesville to Jacksonvillebus bus
    2. Fly from Jacksonville (JAX) to Sioux Falls (FSD)plane plane JAX - FSD
    9h 55m
    $108–490

Gainesville Regional Airport (GNV) to Sioux Falls (FSD) flights

Calendar15Weekly Planes
Duration7h 8mAverage Duration
Ticket$107Cheapest Price
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Comparing Your Travel Options

Map of how to get from Gainesville to Sioux Falls.ExpandLaunch map view
  • Distance: 1,257.6 mi
  • Duration: 7h 23m

What companies run services between Gainesville, FL, USA and Sioux Falls, SD, USA?

Delta and American Airlines fly from Gainesville Regional Airport (GNV) to Sioux Falls (FSD) twice daily. Alternatively, you can take a bus from Gainesville to The Bus Stop via Atlanta Bus Station, St Louis Bus Station, Kansas City Bus Station, Kansas City, Sioux Falls, and Maple/Career NE corner in around 34h 58m.

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