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How to get fromGainesville to Sioux Fallsby plane, bus (Flixbus, Greyhound), bus, train, or car

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There are 7 ways to get from Gainesville to Sioux Falls by plane, bus (Flixbus, Greyhound), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Gainesville Regional Airport

    best
    1. Fly from Gainesville Regional Airport (GNV) to Sioux Falls (FSD)plane plane GNV - FSD
    7h 52m
    $114–504

  2. Bus

    1. Take the bus from Gainesville to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to Omaha, NEbus bus
    4. Take the bus from Omaha to Sioux Fallsbus bus
    39h 38m
    $290–533

  3. Bus, train

    1. Take the bus from Gainesville to Jacksonvillebus bus
    2. Take the train from Jacksonville to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Detroit Lakes Amtrak Stationtrain train
    4. Take the bus from Detroit Lakes to Fargobus bus
    5. Take the bus from Fargo to Sioux Fallsbus bus
    2d 11h
    $798–1,663

  4. Drive 1,442.1 mi

    1. Drive from Gainesville to Sioux Fallscar car 1,442.1 mi
    25h 29m
    $264–381

  5. Bus to Jacksonville, fly

    1. Take the bus from Gainesville to Jacksonvillebus bus
    2. Fly from Jacksonville (JAX) to Sioux Falls (FSD)plane plane JAX - FSD
    10h 16m
    $144–623

  6. Bus to Valdosta, fly

    1. Take the bus from Gainesville to Valdostabus bus
    2. Fly from Valdosta (VLD) to Sioux Falls (FSD)plane plane VLD - FSD
    12h 3m
    $132–527

  7. Bus via Minneapolis

    1. Take the bus from Gainesville to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to Minneapolis Bus Stationbus bus
    4. Take the bus from Minneapolis to Sioux Fallsbus bus
    40h 3m
    $295–548

Gainesville Regional Airport (GNV) to Sioux Falls (FSD) flights

Calendar32Weekly Planes
Duration6h 59mAverage Duration
Ticket$114Cheapest Price
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Questions & Answers

Map of how to get from Gainesville to Sioux Falls.ExpandLaunch map view
  • Distance: 1,257.6 mi
  • Duration: 7h 52m

What companies run services between Gainesville, FL, USA and Sioux Falls, SD, USA?

Delta and American Airlines fly from Gainesville Regional Airport (GNV) to Sioux Falls (FSD) 5 times a day. Alternatively, you can take a bus from Gainesville to The Bus Stop via Atlanta Bus Station, Chicago Bus Station, Omaha, Sioux Falls, and Maple/Career NE corner in around 39h 38m.

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