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How to get fromGainesville to Winston-Salemby plane, bus (Flixbus, Greyhound), bus, train, or car

Find Transport to Winston-Salem

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There are 7 ways to get from Gainesville to Winston-Salem by plane, bus (Flixbus, Greyhound), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Piedmont Triad International Airport

    best
    1. Fly from Gainesville Regional Airport (GNV) to Piedmont Triad International Airport (GSO)plane plane GNV - GSO
    5h 47m
    $130–724

  2. Bus

    cheapest
    1. Take the bus from Gainesville to Jacksonvillebus bus
    2. Take the bus from Jacksonville to Charlotte Bus Stationbus bus
    3. Take the bus from Charlotte Bus Station to Winston Salem(Trans Center)bus bus
    12h
    $72–150

  3. Bus, train via Fayetteville

    1. Take the bus from Gainesville to Jacksonvillebus bus
    2. Take the train from Jacksonville to Fayetteville Amtrak Stationtrain train
    3. Take the bus from Fayetteville to Winston-Salembus bus
    15h 27m
    $134–308

  4. Drive  521.5 mi

    1. Drive from Gainesville to Winston-Salemcar car 521.5 mi
    8h 58m
    $96–138

  5. Fly to Charlotte Douglas International Airport, bus

    1. Fly from Gainesville Regional Airport (GNV) to Charlotte Douglas International Airport (CLT)plane plane GNV - CLT
    2. Take the bus from Charlotte Bus Station to Winston Salem(Trans Center)bus bus
    6h 7m
    $88–528

  6. Bus via Camden

    1. Take the bus from Gainesville to Jacksonvillebus bus
    2. Take the bus from Jacksonville to Camdenbus bus
    3. Take the bus from Camden to Charlotte Bus Stationbus bus
    4. Take the bus from Charlotte Bus Station to Winston Salem(Trans Center)bus bus
    14h 35m
    $79–160

  7. Bus, train

    1. Take the bus from Gainesville to Jacksonvillebus bus
    2. Take the train from Jacksonville to Carytrain train
    3. Take the train from Cary to Greensborotrain train
    4. Take the bus from Greensboro Bus Stop to Winston Salem(Trans Center)bus bus
    17h 8m
    $142–350

Gainesville to Winston-Salem by bus

Calendar6Weekly Buses
Duration12hAverage Duration
Ticket$72Cheapest Price
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Comparing Your Travel Options

Map of how to get from Gainesville to Winston-Salem.ExpandLaunch map view
  • Distance: 491.9 mi
  • Duration: 5h 47m

What companies run services between Gainesville, FL, USA and Winston-Salem, NC, USA?

Delta and American Airlines fly from Gainesville Regional Airport (GNV) to Piedmont Triad International Airport (GSO) every 3 hours. Alternatively, you can take a bus from Gainesville to Winston Salem(Trans Center) via Jacksonville and Charlotte Bus Station in around 12h.

Airlines
Train operators
Bus operators

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