There are 11 ways to get from Genoa to Karlsruhe by train (Trenitalia), bus, car, plane, train, or night train
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Train (Trenitalia)
best- Take the train from Genova Brignole to Milano Centraletrain Ic
- Take the train from Milano Centrale to Karlsruhe Hbftrain Ec
9h 5m€96–173Bus
cheapest- Take the bus from Genoa to Karlsruhe central train stationbus FlixBus N177
10h 50m€60–95Drive 664.5 km
- Drive from Genoa to Karlsruhecar 664.5 km
6h 33m€124–178Fly Genoa Cristoforo Colombo Airport to Stuttgart Airport, train
- Fly from Genoa Cristoforo Colombo Airport (GOA) to Stuttgart Airport (STR)plane GOA - STR
- Take the train from Stuttgart Hbf to Karlsruhe Hbftrain
8h 58m€112–311Train via Basel
- Take the train from Genova Brignole to Milano Centraletrain Ic
- Take the train from Milano Centrale to Basel Sbbtrain Ec
- Take the train from Basel SBB to Karlsruhe Hauptbahnhoftrain 12 / ...
9h 10m€92–223Train, night train
- Take the train from Genova Brignole to Como S.Giovannitrain
- Take the train from Como S. Giovanni to Zürich HBtrain Ec
- Take the nighttrain from Zuerich Hb to Karlsruhe Hbfnighttrain Nj
10h 48m€102–220Train to Milan Linate Airport, fly to Stuttgart Airport, train
- Take the train from Genova P.Za Principe to Milano Forlaninitrain
- Fly from Milan Linate Airport (LIN) to Stuttgart Airport (STR)plane LIN - STR
- Take the train from Stuttgart Hbf to Karlsruhe Hbftrain
6h 46m€128–334Train, train to Nice Côte D'Azur International Airport, fly to Strasbourg International Airport
- Take the train from Genova P.Za Principe to Ventimigliatrain
- Take the train from Ventimiglia to Saint-Laurent-du-Vartrain
- Fly from Nice Côte D'Azur International Airport (NCE) to Strasbourg International Airport (SXB)plane NCE - SXB
- Take the train from Strasbourg to Karlsruhe Hbftrain
7h 45m€74–280Train to Milan Linate Airport, fly to Frankfurt, train
- Take the train from Genova P.Za Principe to Milano Forlaninitrain
- Fly from Milan Linate Airport (LIN) to Frankfurt (FRA)plane LIN - FRA
- Take the train from Frankfurt to Karlsruhe Hauptbahnhoftrain
7h 31m€68–219Train to Turin Caselle Airport, fly to Frankfurt, train
- Take the train from Genova Brignole to Torino Lingottotrain
- Fly from Turin Caselle Airport (TRN) to Frankfurt (FRA)plane TRN - FRA
- Take the train from Frankfurt to Karlsruhe Hauptbahnhoftrain
8h 28m€135–365Train, train to Milano Malpensa Airport, fly to Frankfurt
- Take the train from Genova Brignole to Milano Centraletrain
- Take the train from Milano Centrale to Malpensa Aeroporto T1train
- Fly from Milano Malpensa Airport (MXP) to Frankfurt (FRA)plane MXP - FRA
- Take the train from Frankfurt to Karlsruhe Hauptbahnhoftrain
8h 20m€101–264
Genoa to Karlsruhe by train (Trenitalia)
Comparing Your Travel Options
The cheapest way to get from Genoa to Karlsruhe is to bus which costs €60 - €95 and takes 10h 50m.
The fastest way to get from Genoa to Karlsruhe is to drive which takes 6h 33m and costs €120 - €180.
Yes, there is a direct bus departing from Genoa and arriving at Karlsruhe central train station station. Services depart once daily, and operate every day. The journey takes approximately 10h 50m.
No, there is no direct train from Genoa to Karlsruhe. However, there are services departing from Genova Brignole and arriving at Karlsruhe Hbf via Milano Centrale. The journey, including transfers, takes approximately 9h 5m.
The distance between Genoa and Karlsruhe is 672 km. The road distance is 664.5 km.
The best way to get from Genoa to Karlsruhe without a car is to train which takes 9h 5m and costs €95 - €180.
It takes approximately 9h 5m to get from Genoa to Karlsruhe, including transfers.
Genoa to Karlsruhe bus services, operated by FlixBus, depart from Genoa station.
Genoa to Karlsruhe train services, operated by Trenitalia Intercity, depart from Genova Brignole station.
The best way to get from Genoa to Karlsruhe is to train which takes 9h 5m and costs €95 - €180. Alternatively, you can bus, which costs €60 - €95 and takes 10h 50m.
What companies run services between Genoa, Italy and Karlsruhe, Germany?
You can take a train from Genova Brignole to Karlsruhe Hbf via Milano Centrale in around 9h 5m. Alternatively, FlixBus operates a bus from Genoa to Karlsruhe central train station once daily. Tickets cost €60–95 and the journey takes 10h 50m.
- Website
- lufthansa.com
Flights from Genoa Cristoforo Colombo Airport to Stuttgart Airport via Munich
- Ave. Duration
- 6h 37m
- When
- Thursday to Sunday
- Estimated price
- €120–700
Flights from Milan Linate Airport to Frankfurt
- Ave. Duration
- 1h 15m
- When
- Every day
- Estimated price
- €130–440
Flights from Milan Linate Airport to Frankfurt via Munich
- Ave. Duration
- 3h 25m
- When
- Every day
- Estimated price
- €130–200
Flights from Turin Caselle Airport to Frankfurt
- Ave. Duration
- 1h 25m
- When
- Every day
- Estimated price
- €130–430
Flights from Turin Caselle Airport to Frankfurt via Munich
- Ave. Duration
- 3h 10m
- When
- Monday to Saturday
- Estimated price
- €130–440
Flights from Milano Malpensa Airport to Frankfurt
- Ave. Duration
- 1h 20m
- When
- Every day
- Estimated price
- €75–360
Flights from Milano Malpensa Airport to Frankfurt via Munich
- Ave. Duration
- 3h 17m
- When
- Every day
- Estimated price
- €110–370
- Website
- ita-airways.com
Flights from Genoa Cristoforo Colombo Airport to Stuttgart Airport via Rome
- Ave. Duration
- 4h 40m
- When
- Monday to Friday
- Estimated price
- €120–270
Flights from Milan Linate Airport to Stuttgart Airport
- Ave. Duration
- 1h
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- €90–250
Flights from Milan Linate Airport to Frankfurt
- Ave. Duration
- 1h 15m
- When
- Every day
- Estimated price
- €130–440
Flights from Turin Caselle Airport to Frankfurt
- Ave. Duration
- 1h 25m
- When
- Every day
- Estimated price
- €130–430
Flights from Milano Malpensa Airport to Frankfurt
- Ave. Duration
- 1h 20m
- When
- Every day
- Estimated price
- €75–360
- Website
- airdolomiti.it
Flights from Milan Linate Airport to Frankfurt
- Ave. Duration
- 1h 15m
- When
- Every day
- Estimated price
- €130–440
Flights from Turin Caselle Airport to Frankfurt
- Ave. Duration
- 1h 25m
- When
- Every day
- Estimated price
- €130–430
Flights from Milano Malpensa Airport to Frankfurt
- Ave. Duration
- 1h 20m
- When
- Every day
- Estimated price
- €110–360
- Website
- easyjet.com
Flights from Nice Côte D'Azur International Airport to Strasbourg International Airport
- Ave. Duration
- 1h 21m
- When
- Monday, Thursday, Tuesday, Friday, Sunday, and Wednesday
- Estimated price
- €40–190
Flights from Milan Linate Airport to Frankfurt
- Ave. Duration
- 1h 20m
- When
- Every day
- Estimated price
- €30–140
- Website
- eurowings.com
Flights from Genoa Cristoforo Colombo Airport to Stuttgart Airport via Rome
- Ave. Duration
- 4h 40m
- When
- Monday to Friday
- Estimated price
- €120–270
Flights from Genoa Cristoforo Colombo Airport to Stuttgart Airport via Olbia
- Ave. Duration
- 8h 10m
- When
- Friday
- Estimated price
- €120–270
Flights from Milan Linate Airport to Stuttgart Airport
- Ave. Duration
- 1h
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- €90–250
- Website
- condor.com
Flights from Milano Malpensa Airport to Frankfurt
- Ave. Duration
- 1h 15m
- When
- Every day
- Estimated price
- €60–160
- Website
- swiss.com
Flights from Milano Malpensa Airport to Frankfurt via Zurich
- Ave. Duration
- 3h 15m
- When
- Every day
- Estimated price
- €75–360
- Website
- klm.com
Flights from Genoa Cristoforo Colombo Airport to Stuttgart Airport via Amsterdam Schiphol
- Ave. Duration
- 5h 20m
- When
- Sunday
- Estimated price
- €95–490
- Website
- volotea.com
Flights from Nice Côte D'Azur International Airport to Strasbourg International Airport
- Ave. Duration
- 1h 20m
- When
- Friday and Sunday
- Estimated price
- €30–170
- Phone
- +39 06 68475475
- Website
- Trenitalia Intercity
Train from Genova Brignole to Milano Centrale
- Ave. Duration
- 1h 46m
- Frequency
- Hourly
- Estimated price
- €15–28
- Website
- Trenitalia Intercity
Train from Genova Brignole to Milano Centrale
- Ave. Duration
- 1h 46m
- Frequency
- Hourly
- Estimated price
- €15–28
- Website
- Trenitalia Intercity
Train from Genova P.Za Principe to Ventimiglia
- Ave. Duration
- 2h 6m
- Frequency
- Hourly
- Estimated price
- €15–28
- Website
- Trenitalia Intercity
Train from Genova Brignole to Torino Lingotto
- Ave. Duration
- 2h 3m
- Frequency
- 4 times a day
- Estimated price
- €17–35
- Website
- Trenitalia Intercity
Train from Genova Brignole to Milano Centrale
- Ave. Duration
- 1h 46m
- Frequency
- Hourly
- Estimated price
- €15–28
- Website
- Trenitalia Intercity
- Phone
- +39.06.5210550
- Website
- Trenitalia
Train from Genova Brignole to Milano Centrale
- Ave. Duration
- 2h 3m
- Frequency
- Every 3 hours
- Estimated price
- €16–23
- Website
- Trenitalia
Train from Genova Brignole to Milano Centrale
- Ave. Duration
- 2h 3m
- Frequency
- Every 3 hours
- Estimated price
- €16–23
- Website
- Trenitalia
Train from Genova P.Za Principe to Milano Forlanini
- Ave. Duration
- 2h 1m
- Frequency
- Hourly
- Estimated price
- €16–22
- Website
- Trenitalia
Train from Genova P.Za Principe to Ventimiglia
- Ave. Duration
- 2h 19m
- Frequency
- Hourly
- Estimated price
- €16–23
- Website
- Trenitalia
Train from Genova P.Za Principe to Milano Forlanini
- Ave. Duration
- 2h 1m
- Frequency
- Hourly
- Estimated price
- €16–22
- Website
- Trenitalia
Train from Genova Brignole to Torino Lingotto
- Ave. Duration
- 2h 9m
- Frequency
- Hourly
- Estimated price
- €18–26
- Website
- Trenitalia
Train from Genova Brignole to Milano Centrale
- Ave. Duration
- 2h 3m
- Frequency
- Every 3 hours
- Estimated price
- €16–23
- Website
- Trenitalia
- Phone
- +39 06 5210550
- Website
- Trenitalia Frecce
Train from Genova Brignole to Milano Centrale
- Ave. Duration
- 1h 38m
- Frequency
- 3 times a day
- Estimated price
- €19–35
- Website
- Trenitalia Frecce
Train from Genova Brignole to Milano Centrale
- Ave. Duration
- 1h 38m
- Frequency
- 3 times a day
- Estimated price
- €19–35
- Website
- Trenitalia Frecce
Train from Genova Brignole to Torino Lingotto
- Ave. Duration
- 1h 44m
- Frequency
- 3 times a day
- Estimated price
- €21–40
- Website
- Trenitalia Frecce
Train from Genova Brignole to Milano Centrale
- Ave. Duration
- 1h 38m
- Frequency
- 3 times a day
- Estimated price
- €19–35
- Website
- Trenitalia Frecce
- Phone
- +39 06 68475475
- [email protected]
- Website
- Trenitalia Eurocity
Train from Milano Centrale to Karlsruhe Hbf
- Ave. Duration
- 6h 19m
- Frequency
- Twice daily
- Estimated price
- €80–140
- Website
- Trenitalia Eurocity
- 1st Class
- €80–120
- 2nd Class
- €100–140
Train from Milano Centrale to Basel Sbb
- Ave. Duration
- 4h 21m
- Frequency
- Every 2 hours
- Estimated price
- €55–95
- Website
- Trenitalia Eurocity
- 1st Class
- €55–80
- 2nd Class
- €65–95
Train from Basel SBB to Karlsruhe Hauptbahnhof
- Ave. Duration
- 1h 43m
- Frequency
- Twice daily
- Estimated price
- €45–95
- Website
- Trenitalia Eurocity
- 1st Class
- €65–95
- 2nd Class
- €45–65
- Phone
- +49 711 400 534 44
- [email protected]
- Website
- Arverio Baden-Württemberg
Train from Stuttgart Hbf to Karlsruhe Hbf
- Ave. Duration
- 54 min
- Frequency
- Every 30 minutes
- Estimated price
- €14–27
- Schedules at
- Arverio Baden-Württemberg
- 2nd Class Ticket
- €14–18
- 1st Class Ticket
- €18–27
Train from Stuttgart Hbf to Karlsruhe Hbf
- Ave. Duration
- 54 min
- Frequency
- Every 30 minutes
- Estimated price
- €14–27
- Schedules at
- Arverio Baden-Württemberg
- 2nd Class Ticket
- €14–18
- 1st Class Ticket
- €18–27
- Phone
- +49 711 400 534 44
- [email protected]
- Website
- Arverio Baden-Württemberg GmbH
Train from Stuttgart Hbf to Karlsruhe Hbf
- Ave. Duration
- 53 min
- Frequency
- Hourly
- Estimated price
- €14–20
- Schedules at
- Arverio Baden-Württemberg GmbH
Train from Stuttgart Hbf to Karlsruhe Hbf
- Ave. Duration
- 53 min
- Frequency
- Hourly
- Estimated price
- €14–20
- Schedules at
- Arverio Baden-Württemberg GmbH
- Phone
- +49 30 2970
- Website
- Deutsche Bahn Intercity (DB IC)
Train from Stuttgart Hbf to Karlsruhe Hbf
- Ave. Duration
- 54 min
- Frequency
- Hourly
- Estimated price
- €13–26
- Website
- Deutsche Bahn Intercity (DB IC)
Train from Basel SBB to Karlsruhe Hauptbahnhof
- Ave. Duration
- 1h 41m
- Frequency
- Hourly
- Estimated price
- €30–65
- Website
- Deutsche Bahn Intercity (DB IC)
Train from Stuttgart Hbf to Karlsruhe Hbf
- Ave. Duration
- 54 min
- Frequency
- Hourly
- Estimated price
- €13–26
- Website
- Deutsche Bahn Intercity (DB IC)
Train from Strasbourg to Karlsruhe Hbf
- Ave. Duration
- 40 min
- Frequency
- Hourly
- Estimated price
- €12–25
- Website
- Deutsche Bahn Intercity (DB IC)
Train from Frankfurt to Karlsruhe Hauptbahnhof
- Ave. Duration
- 1h 8m
- Frequency
- Every 3 hours
- Estimated price
- €21–45
- Website
- Deutsche Bahn Intercity (DB IC)
Train from Frankfurt to Karlsruhe Hauptbahnhof
- Ave. Duration
- 1h 8m
- Frequency
- Every 3 hours
- Estimated price
- €21–45
- Website
- Deutsche Bahn Intercity (DB IC)
Train from Frankfurt to Karlsruhe Hauptbahnhof
- Ave. Duration
- 1h 8m
- Frequency
- Every 3 hours
- Estimated price
- €21–45
- Website
- Deutsche Bahn Intercity (DB IC)
- Phone
- +49 30 2970
- Website
- Deutsche Bahn Regio (DB Regional)
Train from Stuttgart Hbf to Karlsruhe Hbf
- Ave. Duration
- 1h 28m
- Frequency
- Once daily
- Estimated price
- €9–13
- Website
- Deutsche Bahn Regio (DB Regional)
Train from Basel SBB to Karlsruhe Hauptbahnhof
- Ave. Duration
- 2h 54m
- Frequency
- Once daily
- Estimated price
- €21–30
- Website
- Deutsche Bahn Regio (DB Regional)
Train from Stuttgart Hbf to Karlsruhe Hbf
- Ave. Duration
- 1h 28m
- Frequency
- Once daily
- Estimated price
- €9–13
- Website
- Deutsche Bahn Regio (DB Regional)
- Phone
- +43 5 1717
- Website
- Österreichische Bundesbahnen
Train from Basel SBB to Karlsruhe Hauptbahnhof
- Ave. Duration
- 1h 58m
- Frequency
- 3 times a day
- Estimated price
- €40–65
- Website
- Österreichische Bundesbahnen
- Phone
- +39 02 7249 4494
- [email protected]
- Website
- Trenord
Train from Genova Brignole to Como S.Giovanni
- Ave. Duration
- 3h 4m
- Frequency
- Twice a week
- Estimated price
- €12–16
- Website
- Trenord
Train from Milano Centrale to Malpensa Aeroporto T1
- Ave. Duration
- 53 min
- Frequency
- Every 30 minutes
- Estimated price
- €4–6
- Website
- Trenord
Train from Como S. Giovanni to Zürich HB
- Ave. Duration
- 2h 36m
- Frequency
- Hourly
- Estimated price
- €65–110
- Website
- Swiss Federal Railways (SBB CFF FFS)
- Phone
- +43 (0) 51717
- Website
- Nightjet
Night train from Zuerich Hb to Karlsruhe Hbf
- Ave. Duration
- 3h 14m
- Frequency
- 4 times a day
- Estimated price
- €24–93
- Website
- Nightjet
- Sleeper Carriage
- €88–93
- Couchette Carriage
- €55–65
- Seating Carriage
- €24–29
- Phone
- +33 4 13 94 30 50
- Website
- ZOU!
Train from Ventimiglia to Saint-Laurent-du-Var
- Ave. Duration
- 1h 9m
- Frequency
- Every 15 minutes
- Schedules at
- ZOU!
- Phone
- +33 4 13 94 30 50
- Website
- Zou! Lignes Express Régionales
Train from Ventimiglia to Saint-Laurent-du-Var
- Ave. Duration
- 1h 12m
- Frequency
- Hourly
- Estimated price
- €10–15
- Website
- Zou! Lignes Express Régionales
- Phone
- +33 1 84 94 36 35
- Website
- TGV inOui
Train from Strasbourg to Karlsruhe Hbf
- Ave. Duration
- 44 min
- Frequency
- Every 2 hours
- Estimated price
- €15–24
- Website
- TGV inOui
- Phone
- +33 1 84 94 36 35
- Website
- Oui.SNCF
Train from Strasbourg to Karlsruhe Hbf
- Ave. Duration
- 49 min
- Frequency
- Twice a week
- Estimated price
- €15–24
- Website
- Oui.SNCF
Rome2Rio's guide to FlixBus
Contact Details
- Phone
- +49 30 300 137 300
- [email protected]
- Website
- Flixbus
Bus from Genoa to Karlsruhe central train station
- Ave. Duration
- 10h 50m
- Frequency
- Once daily
- Estimated price
- €60–95
- Website
- Flixbus
Want to know more about travelling around Germany
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Italy Travel Guides
Read the travel guide
Want to know more about Flixbus?
Read the travel guide
Heading to Europe? Read this before you buy a Eurail Pass
Read the travel guide
Booking & Getting There
Genoa to Karlsruhe bus services, operated by FlixBus, arrive at Karlsruhe central train station.
Genoa to Karlsruhe train services, operated by Trenitalia Intercity, arrive at Milano Centrale station.
Yes, the driving distance between Genoa to Karlsruhe is 665 km. It takes approximately 6h 33m to drive from Genoa to Karlsruhe.
Book your Genoa to Karlsruhe train tickets online with Omio.
Book your Genoa to Karlsruhe bus tickets online with Omio and FlixBus.
There are 901+ hotels available in Karlsruhe.





























































