Rome2Rio

How to get fromGrafton to Mayo Clinicby bus, train, car, or plane

Find Transport to Mayo Clinic

See all options

There are 6 ways to get from Grafton to Mayo Clinic by bus, train, car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Milwaukee to Rochesterbus bus Jefferson Lines 966
    7h 51m
    $100–137

  2. Drive 255.3 mi

    cheapest
    1. Drive from Grafton to Mayo Cliniccar car 255.3 mi
    5h 1m
    $47–68

  3. Train, bus

    1. Take the train from Milwaukee to St. Paul-Minneapolistrain train Borealis / ...
    2. Take the bus from St. Paul to Rochesterbus bus Jefferson Lines 965
    8h 53m
    $185–327

  4. Fly General Mitchell International Airport to Rochester

    1. Fly from General Mitchell International Airport (MKE) to Rochester (RST)plane plane MKE - RST
    7h 14m
    $109–524

  5. Fly General Mitchell International Airport to Minneapolis–Saint Paul International Airport, bus

    1. Fly from General Mitchell International Airport (MKE) to Minneapolis–Saint Paul International Airport (MSP)plane plane MKE - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    6h 42m
    $690–1,096

  6. Bus to Chicago O'Hare International Airport, fly to Rochester

    1. Take the bus from Milwaukee Intermodal/Amtrak Station to O'Hare International Airport - Terminal 2 Departuresbus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Rochester (RST)plane plane ORD - RST
    7h 18m
    $109–409

General Mitchell International Airport (MKE) to Rochester (RST) flights

Calendar49Weekly Planes
Duration4h 15mAverage Duration
Ticket$69Cheapest Price
See schedules

Questions & Answers

Map of how to get from Grafton to Mayo Clinic.ExpandLaunch map view
  • Distance: 301.1 mi
  • Duration: 7h 51m

What companies run services between Grafton, WI, USA and Mayo Clinic, MN, USA?

Jefferson Lines operates a bus from Milwaukee to Rochester once daily. Tickets cost $70–100 and the journey takes 5h 40m. Alternatively, Delta, American Airlines, and United Airlines fly from General Mitchell International Airport (MKE) to Rochester (RST) every 4 hours.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

More Questions & Answers