Rome2Rio

How to get fromGreat Smoky Mountains to Buffaloby car, plane, bus, or train

Find Transport to Buffalo

See all options

There are 8 ways to get from Great Smoky Mountains to Buffalo by car, plane, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive to Mcghee Tyson Airport, fly

    best
    1. Drive from Great Smoky Mountains to Mcghee Tyson Airport (TYS)car car
    2. Fly from Mcghee Tyson Airport (TYS) to Buffalo Niagara International Airport (BUF)plane plane TYS - BUF
    6h 42m
    $173–895

  2. Drive, bus

    cheapest
    1. Drive from Great Smoky Mountains to New Leicester Hwy at Walgreenscar car
    2. Take the bus from Asheville, NC to Winston Salem(Trans Center)bus bus
    3. Take the bus from Winston Salem(Trans Center) to Columbus - Mound Stbus bus
    4. Take the bus from Columbus - Mound St to Buffalo, NYbus bus
    24h 21m
    $106–235

  3. Drive, bus, train

    1. Drive from Great Smoky Mountains to Knoxville, TNcar car
    2. Take the bus from Knoxville, TN to New York, NYbus bus Ny
    3. Take the train from New York Penn Station to Buffalotrain train
    23h 49m
    $220–420

  4. Drive, bus, train via Greensboro

    1. Drive from Great Smoky Mountains to Asheville, NCcar car
    2. Take the bus from Asheville, NC to Greensboro Bus Stopbus bus
    3. Take the train from Greensboro to Ny Moynihan Train Hall At Penn Stationtrain train
    4. Take the train from Ny Moynihan Train Hall At Penn Station to Buffalotrain train
    27h 6m
    $340–700

  5. Drive 719.3 mi

    1. Drive from Great Smoky Mountains to Buffalocar car 719.3 mi
    13h 3m
    $132–190

  6. Drive to Asheville Regional Airport, fly

    1. Drive from Great Smoky Mountains to Asheville-Airport-AVLcar car
    2. Fly from Asheville Regional Airport (AVL) to Buffalo Niagara International Airport (BUF)plane plane AVL - BUF
    7h 16m
    $117–650

  7. Drive to Greenville–Spartanburg International Airport, fly

    1. Drive from Great Smoky Mountains to Greenville–Spartanburg International Airport (GSP)car car
    2. Fly from Greenville–Spartanburg International Airport (GSP) to Buffalo Niagara International Airport (BUF)plane plane GSP - BUF
    7h 50m
    $156–764

  8. Drive, bus via New York

    1. Drive from Great Smoky Mountains to Knoxville, TNcar car
    2. Take the bus from Knoxville, TN to New York, NYbus bus Ny
    3. Take the bus from New York Midtown to Buffalobus bus
    23h 59m
    $180–250

Mcghee Tyson Airport (TYS) to Buffalo Niagara International Airport (BUF) flights

Calendar98Weekly Planes
Duration5h 9mAverage Duration
Ticket$162Cheapest Price
See schedules

Questions & Answers

Map of how to get from Great Smoky Mountains to Buffalo.ExpandLaunch map view
  • Distance: 640.6 mi
  • Duration: 6h 42m

What companies run services between Great Smoky Mountains, TN, USA and Buffalo, NY, USA?

There is no direct connection from Great Smoky Mountains to Buffalo. However, you can drive to Mcghee Tyson Airport (TYS) airport, fly to Buffalo Niagara International Airport (BUF), walk to BNIA Driveway & BNIA Terminal, then take the bus to Washington Street & Eagle Street. Alternatively, you can take a vehicle from Great Smoky Mountains to Buffalo via Knoxville, TN, New York, NY, East Broadway, 34 St-Herald Sq, and New York Penn Station in around 23h 49m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound