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How to get fromGreat Smoky Mountains to Chicagoby car, plane, or bus

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There are 7 ways to get from Great Smoky Mountains to Chicago by car, plane, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive to Mcghee Tyson Airport, fly to Chicago O'Hare International Airport

    best
    1. Drive from Great Smoky Mountains to Mcghee Tyson Airport (TYS)car car
    2. Fly from Mcghee Tyson Airport (TYS) to Chicago O'Hare International Airport (ORD)plane plane TYS - ORD
    4h 33m
    $83–431

  2. Drive to Asheville Regional Airport, fly to Chicago O'Hare International Airport

    cheapest
    1. Drive from Great Smoky Mountains to Asheville-Airport-AVLcar car
    2. Fly from Asheville Regional Airport (AVL) to Chicago O'Hare International Airport (ORD)plane plane AVL - ORD
    4h 53m
    $67–316

  3. Drive, bus

    1. Drive from Great Smoky Mountains to Knoxvillecar car
    2. Take the bus from Knoxville to Nashvillebus bus Nyc
    3. Take the bus from Nashville Bus Station to Chicago Bus Stationbus bus
    16h 44m
    $128–224

  4. Drive 583.4 mi

    1. Drive from Great Smoky Mountains to Chicagocar car 583.4 mi
    11h 3m
    $107–154

  5. Drive to Mcghee Tyson Airport, fly to Chicago Midway International Airport

    1. Drive from Great Smoky Mountains to Mcghee Tyson Airport (TYS)car car
    2. Fly from Mcghee Tyson Airport (TYS) to Chicago Midway International Airport (MDW)plane plane TYS - MDW
    4h 8m
    $93–491

  6. Drive to Asheville Regional Airport, fly to Chicago Midway International Airport

    1. Drive from Great Smoky Mountains to Asheville-Airport-AVLcar car
    2. Fly from Asheville Regional Airport (AVL) to Chicago Midway International Airport (MDW)plane plane AVL - MDW
    7h 10m
    $87–396

  7. Drive to Greenville–Spartanburg International Airport, fly to Chicago O'Hare International Airport

    1. Drive from Great Smoky Mountains to Greenville–Spartanburg International Airport (GSP)car car
    2. Fly from Greenville–Spartanburg International Airport (GSP) to Chicago O'Hare International Airport (ORD)plane plane GSP - ORD
    6h 5m
    $91–410

Mcghee Tyson Airport (TYS) to Chicago O'Hare International Airport (ORD) flights

Calendar85Weekly Planes
Duration3h 13mAverage Duration
Ticket$71Cheapest Price
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Questions & Answers

Map of how to get from Great Smoky Mountains to Chicago.ExpandLaunch map view
  • Distance: 553 mi
  • Duration: 4h 33m

What companies run services between Great Smoky Mountains, TN, USA and Chicago, IL, USA?

There is no direct connection from Great Smoky Mountains to Chicago. However, you can drive to Mcghee Tyson Airport (TYS) airport, fly to Chicago O'Hare International Airport (ORD), walk to O'Hare, then take the subway to Jackson-Blue. Alternatively, you can take a vehicle from Great Smoky Mountains to Chicago Bus Station via Knoxville, Nashville, Charlotte Pike & Lellyett St Eb, Central 5Th Ave - Bay 1, Central 4Th Ave - Bay 13, Fulton Station Outbound, and Nashville Bus Station in around 16h 44m.

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