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How to get fromGreat Smoky Mountains to Columbiaby car, plane, bus, or train

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There are 4 ways to get from Great Smoky Mountains to Columbia by car, plane, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive, fly

    best
    1. Drive from Great Smoky Mountains to Mcghee Tyson Airport (TYS)car car
    2. Fly from Mcghee Tyson Airport (TYS) to Columbia (CAE)plane plane TYS - CAE
    6h 37m
    $73–448

  2. Drive 222.8 mi

    cheapest
    1. Drive from Great Smoky Mountains to Columbiacar car 222.8 mi
    4h 26m
    $41–59

  3. Drive, bus

    1. Drive from Great Smoky Mountains to Asheville, NCcar car
    2. Take the bus from Asheville, NC to Winston Salem(Trans Center)bus bus
    3. Take the bus from Winston Salem(Trans Center) to Charlotte Bus Stationbus bus
    4. Take the bus from Charlotte Bus Station to Camdenbus bus
    5. Take the bus from Camden to Columbia, SCbus bus Nyc
    11h 50m
    $87–152

  4. Drive, bus, train

    1. Drive from Great Smoky Mountains to Asheville, NCcar car
    2. Take the bus from Asheville, NC to Greensboro Bus Stopbus bus
    3. Take the train from Greensboro to Carytrain train
    4. Take the train from Cary to Columbia Stationtrain train
    12h 54m
    $121–250

Mcghee Tyson Airport (TYS) to Columbia (CAE) flights

Calendar148Weekly Planes
Duration4h 36mAverage Duration
Ticket$64Cheapest Price
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Questions & Answers

Map of how to get from Great Smoky Mountains to Columbia.ExpandLaunch map view
  • Distance: 275.9 mi
  • Duration: 6h 37m

What companies run services between Great Smoky Mountains, TN, USA and Columbia, SC, USA?

There is no direct connection from Great Smoky Mountains to Columbia. However, you can drive to Mcghee Tyson Airport (TYS) airport, fly to Columbia (CAE), walk to Columbia Metropolitan Airport, then take the line 91 bus to Assembly Gervais North. Alternatively, you can take a vehicle from Great Smoky Mountains to Sumter Laurel South via Asheville, NC, Winston Salem(Trans Center), Charlotte Bus Station, Camden, Columbia, SC, and Broad Marley South in around 11h 50m.

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