Rome2Rio

How to get fromGreat Smoky Mountains to Gainesvilleby car, plane, bus, or train

Find Transport to Gainesville

See all options

There are 7 ways to get from Great Smoky Mountains to Gainesville by car, plane, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive to Mcghee Tyson Airport, fly to Gainesville Regional Airport

    best
    1. Drive from Great Smoky Mountains to Mcghee Tyson Airport (TYS)car car
    2. Fly from Mcghee Tyson Airport (TYS) to Gainesville Regional Airport (GNV)plane plane TYS - GNV
    6h 34m
    $98–508

  2. Drive to Asheville Regional Airport, fly to Orlando Sanford, drive

    cheapest
    1. Drive from Great Smoky Mountains to Asheville-Airport-AVLcar car
    2. Fly from Asheville Regional Airport (AVL) to Orlando Sanford (SFB)plane plane AVL - SFB
    3. Drive from Orlando-Sanford-Airport-SFB to Gainesvillecar car
    5h 59m
    $90–391

  3. Drive, bus

    1. Drive from Great Smoky Mountains to Knoxvillecar car
    2. Take the bus from Knoxville to Nashvillebus bus Nyc
    3. Take the bus from Nashville Bus Station to Atlanta Bus Stationbus bus
    4. Take the bus from Atlanta Bus Station to Gainesvillebus bus
    17h 3m
    $143–244

  4. Drive, bus, train

    1. Drive from Great Smoky Mountains to Asheville, NCcar car
    2. Take the bus from Asheville, NC to Greensboro Bus Stopbus bus
    3. Take the train from Greensboro to Carytrain train
    4. Take the train from Cary to Jacksonvilletrain train
    5. Take the bus from Jacksonville to Gainesvillebus bus
    22h 25m
    $225–461

  5. Drive 495.6 mi

    1. Drive from Great Smoky Mountains to Gainesvillecar car 495.6 mi
    9h 39m
    $91–131

  6. Drive to Mcghee Tyson Airport, fly to Orlando Sanford, drive

    1. Drive from Great Smoky Mountains to Mcghee Tyson Airport (TYS)car car
    2. Fly from Mcghee Tyson Airport (TYS) to Orlando Sanford (SFB)plane plane TYS - SFB
    3. Drive from Orlando-Sanford-Airport-SFB to Gainesvillecar car
    5h 53m
    $121–546

  7. Drive to Mcghee Tyson Airport, fly to Orlando, bus

    1. Drive from Great Smoky Mountains to Mcghee Tyson Airport (TYS)car car
    2. Fly from Mcghee Tyson Airport (TYS) to Orlando (MCO)plane plane TYS - MCO
    3. Take the bus from Orlando - RedCoach Station, FL to University of Florida - 1956 Gale Lemerand Drbus bus
    7h 16m
    $132–573

Mcghee Tyson Airport (TYS) to Gainesville Regional Airport (GNV) flights

Calendar54Weekly Planes
Duration4h 30mAverage Duration
Ticket$85Cheapest Price
See schedules

Questions & Answers

Map of how to get from Great Smoky Mountains to Gainesville.ExpandLaunch map view
  • Distance: 501.6 mi
  • Duration: 6h 34m

What companies run services between Great Smoky Mountains, TN, USA and Gainesville, FL, USA?

There is no direct connection from Great Smoky Mountains to Gainesville. However, you can drive to Mcghee Tyson Airport (TYS) airport, fly to Gainesville Regional Airport (GNV), walk to Airport, then take the line 26 bus to Rosa Parks RTS Downtown Station. Alternatively, you can take a vehicle from Great Smoky Mountains to Gainesville via Knoxville, Nashville, Charlotte Pike & Lellyett St Eb, Central 5Th Ave - Bay 1, Central 4Th Ave - Bay 13, Fulton Station Outbound, Nashville Bus Station, and Atlanta Bus Station in around 17h 3m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound