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How to get fromGreat Smoky Mountains to Indianapolisby car, plane, or bus

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There are 5 ways to get from Great Smoky Mountains to Indianapolis by car, plane, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive to Mcghee Tyson Airport, fly

    best
    1. Drive from Great Smoky Mountains to Mcghee Tyson Airport (TYS)car car
    2. Fly from Mcghee Tyson Airport (TYS) to Indianapolis (IND)plane plane TYS - IND
    6h 8m
    $123–718

  2. Drive 403.9 mi

    cheapest
    1. Drive from Great Smoky Mountains to Indianapoliscar car 403.9 mi
    7h 51m
    $74–107

  3. Drive, bus

    1. Drive from Great Smoky Mountains to Knoxvillecar car
    2. Take the bus from Knoxville to Nashvillebus bus Nyc
    3. Take the bus from Nashville Bus Station to Indianapolis Union Stationbus bus
    12h 39m
    $103–139

  4. Drive to Asheville Regional Airport, fly

    1. Drive from Great Smoky Mountains to Asheville-Airport-AVLcar car
    2. Fly from Asheville Regional Airport (AVL) to Indianapolis (IND)plane plane AVL - IND
    6h 29m
    $107–523

  5. Drive, bus via Indianapolis

    1. Drive from Great Smoky Mountains to Knoxvillecar car
    2. Take the bus from Knoxville to Nashvillebus bus Nyc
    3. Take the bus from Nashville Bus Station to Indianapolisbus bus
    13h 39m
    $108–169

Mcghee Tyson Airport (TYS) to Indianapolis (IND) flights

Calendar126Weekly Planes
Duration4h 36mAverage Duration
Ticket$115Cheapest Price
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Questions & Answers

Map of how to get from Great Smoky Mountains to Indianapolis.ExpandLaunch map view
  • Distance: 372.7 mi
  • Duration: 6h 8m

What companies run services between Great Smoky Mountains, TN, USA and Indianapolis, IN, USA?

There is no direct connection from Great Smoky Mountains to Indianapolis. However, you can drive to Mcghee Tyson Airport (TYS) airport, fly to Indianapolis (IND), walk to Indianapolis Airport, then take the line 8 bus to Ctc-M. Alternatively, you can take a vehicle from Great Smoky Mountains to Indianapolis Union Station via Knoxville, Nashville, Charlotte Pike & Lellyett St Eb, Central 5Th Ave - Bay 1, Central 4Th Ave - Bay 13, Fulton Station Outbound, and Nashville Bus Station in around 12h 39m.

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