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How to get fromGreat Smoky Mountains to Louisvilleby car, plane, or bus

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There are 5 ways to get from Great Smoky Mountains to Louisville by car, plane, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive to Mcghee Tyson Airport, fly

    best
    1. Drive from Great Smoky Mountains to Mcghee Tyson Airport (TYS)car car
    2. Fly from Mcghee Tyson Airport (TYS) to Louisville International Airport (SDF)plane plane TYS - SDF
    5h 49m
    $112–669

  2. Drive 291.2 mi

    cheapest
    1. Drive from Great Smoky Mountains to Louisvillecar car 291.2 mi
    6h 21m
    $54–77

  3. Drive, bus

    1. Drive from Great Smoky Mountains to Knoxvillecar car
    2. Take the bus from Knoxville to Nashvillebus bus Nyc
    3. Take the bus from Nashville to Louisville, KYbus bus
    10h 24m
    $88–134

  4. Drive to Asheville Regional Airport, fly

    1. Drive from Great Smoky Mountains to Asheville-Airport-AVLcar car
    2. Fly from Asheville Regional Airport (AVL) to Louisville International Airport (SDF)plane plane AVL - SDF
    6h 37m
    $96–504

  5. Drive, bus via Preston @ Vim

    1. Drive from Great Smoky Mountains to Knoxvillecar car
    2. Take the bus from Knoxville to Nashvillebus bus Nyc
    3. Take the bus from Tornado Bus Co - Nashville to La Tropicana - Louisville, KYbus bus
    11h 14m
    $109–237

Mcghee Tyson Airport (TYS) to Louisville International Airport (SDF) flights

Calendar94Weekly Planes
Duration4h 21mAverage Duration
Ticket$101Cheapest Price
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Questions & Answers

Map of how to get from Great Smoky Mountains to Louisville.ExpandLaunch map view
  • Distance: 256.7 mi
  • Duration: 5h 49m

What companies run services between Great Smoky Mountains, TN, USA and Louisville, KY, USA?

There is no direct connection from Great Smoky Mountains to Louisville. However, you can drive to Mcghee Tyson Airport (TYS) airport, fly to Louisville International Airport (SDF), walk to Louisville International Airport, then take the line 02 bus to 2nd @ York. Alternatively, you can take a vehicle from Great Smoky Mountains to Louisville, KY via Knoxville, Nashville, Charlotte Pike & Lellyett St Eb, Central 5Th Ave - Bay 1, Central 4Th Ave - Bay 13, Fulton Station Outbound, and Nashville in around 10h 24m.

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