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How to get fromGreat Smoky Mountains to Milwaukeeby car, plane, bus, or train

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There are 8 ways to get from Great Smoky Mountains to Milwaukee by car, plane, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive to Mcghee Tyson Airport, fly to General Mitchell International Airport

    best
    1. Drive from Great Smoky Mountains to Mcghee Tyson Airport (TYS)car car
    2. Fly from Mcghee Tyson Airport (TYS) to General Mitchell International Airport (MKE)plane plane TYS - MKE
    6h 26m
    $144–769

  2. Drive to Asheville Regional Airport, fly to Chicago O'Hare International Airport, bus

    cheapest
    1. Drive from Great Smoky Mountains to Asheville-Airport-AVLcar car
    2. Fly from Asheville Regional Airport (AVL) to Chicago O'Hare International Airport (ORD)plane plane AVL - ORD
    3. Take the bus from Chicago to Milwaukee Intermodal Stationbus bus
    6h 38m
    $79–339

  3. Drive, bus, train via Carbondale

    1. Drive from Great Smoky Mountains to Knoxvillecar car
    2. Take the bus from Knoxville to Nashvillebus bus Nyc
    3. Take the bus from Central 5Th Ave - Bay 11 to Clarksville Exit 11 Park And Ridebus bus 94
    4. Take the bus from Clarksville Park & Ride to Carbondale Intermodal Stationbus bus
    5. Take the train from Carbondale to Chicago Union Stationtrain train
    6. Take the train from Chicago Union Station to Milwaukeetrain train
    20h 34m
    $211–399

  4. Drive, bus, train

    1. Drive from Great Smoky Mountains to Asheville, NCcar car
    2. Take the bus from Asheville, NC to Greensboro Bus Stopbus bus
    3. Take the train from Greensboro to Carytrain train
    4. Take the train from Cary to Chicago Union Stationtrain train
    5. Take the train from Chicago Union Station to Milwaukeetrain train
    36h 26m
    $430–930

  5. Drive 671.3 mi

    1. Drive from Great Smoky Mountains to Milwaukeecar car 671.3 mi
    12h 45m
    $123–177

  6. Drive to Mcghee Tyson Airport, fly to Chicago O'Hare International Airport, bus

    1. Drive from Great Smoky Mountains to Mcghee Tyson Airport (TYS)car car
    2. Fly from Mcghee Tyson Airport (TYS) to Chicago O'Hare International Airport (ORD)plane plane TYS - ORD
    3. Take the bus from Chicago to Milwaukee Intermodal Stationbus bus
    6h 18m
    $95–454

  7. Drive, bus via Memphis

    1. Drive from Great Smoky Mountains to Knoxvillecar car
    2. Take the bus from Knoxville to Jacksonbus bus Nyc
    3. Take the bus from El Mezcal Grocery - Jackson, TN to Tornado Bus Co - West Memphisbus bus
    4. Take the bus from Tornado Bus Co - West Memphis to Water & Chicago - Circle Kbus bus
    22h 50m
    $204–465

  8. Drive, bus

    1. Drive from Great Smoky Mountains to New Leicester Hwy at Walgreenscar car
    2. Take the bus from Asheville, NC to Winston Salem(Trans Center)bus bus
    3. Take the bus from Winston Salem(Trans Center) to Columbus - Mound Stbus bus
    4. Take the bus from Columbus - Mound St to Chicagobus bus
    5. Take the bus from Chicago Bus Station to Milwaukee Intermodal Stationbus bus
    27h 26m
    $114–261

Mcghee Tyson Airport (TYS) to General Mitchell International Airport (MKE) flights

Calendar118Weekly Planes
Duration4h 58mAverage Duration
Ticket$132Cheapest Price
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Questions & Answers

Map of how to get from Great Smoky Mountains to Milwaukee.ExpandLaunch map view
  • Distance: 602.4 mi
  • Duration: 6h 26m

What companies run services between Great Smoky Mountains, TN, USA and Milwaukee, WI, USA?

There is no direct connection from Great Smoky Mountains to Milwaukee. However, you can drive to Mcghee Tyson Airport (TYS) airport, fly to General Mitchell International Airport (MKE), walk to Airport Baggage Claim, then take the bus to Water & Chicago. Alternatively, you can take a vehicle from Great Smoky Mountains to Milwaukee via Knoxville, Nashville, Charlotte Pike & Lellyett St Eb, Central 5Th Ave - Bay 1, Central 5Th Ave - Bay 11, Clarksville Exit 11 Park And Ride, Clarksville Park & Ride, Carbondale Intermodal Station, Carbondale, and Chicago Union Station in around 20h 34m.

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