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How to get fromGreat Smoky Mountains to Myrtle Beachby car, plane, bus, or train

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There are 7 ways to get from Great Smoky Mountains to Myrtle Beach by car, plane, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive to Mcghee Tyson Airport, fly

    best
    1. Drive from Great Smoky Mountains to Mcghee Tyson Airport (TYS)car car
    2. Fly from Mcghee Tyson Airport (TYS) to Myrtle Beach (MYR)plane plane TYS - MYR
    5h 19m
    $82–420

  2. Drive to Asheville Regional Airport, fly

    cheapest
    1. Drive from Great Smoky Mountains to Asheville-Airport-AVLcar car
    2. Fly from Asheville Regional Airport (AVL) to Myrtle Beach (MYR)plane plane AVL - MYR
    5h 45m
    $61–295

  3. Drive, bus via Camden (Greyhound)

    1. Drive from Great Smoky Mountains to Asheville, NCcar car
    2. Take the bus from Asheville, NC to Winston Salem(Trans Center)bus bus
    3. Take the bus from Winston Salem(Trans Center) to Charlotte Bus Stationbus bus
    4. Take the bus from Charlotte Bus Station to Camdenbus bus
    5. Take the bus from Camden to Myrtle Beach Bus Stationbus bus
    13h 43m
    $75–145

  4. Drive 360.8 mi

    1. Drive from Great Smoky Mountains to Myrtle Beachcar car 360.8 mi
    7h 27m
    $66–96

  5. Drive, bus (Greyhound)

    1. Drive from Great Smoky Mountains to Asheville, NCcar car
    2. Take the bus from Asheville, NC to Raleigh Bus Stationbus bus
    3. Take the bus from Raleigh Bus Station to Wilmington Cape Fear Public Transitbus bus
    4. Take the bus from Wilmington Cape Fear Public Transit to Myrtle Beach Bus Stationbus bus
    13h 53m
    $82–162

  6. Drive, bus, train

    1. Drive from Great Smoky Mountains to Asheville, NCcar car
    2. Take the bus from Asheville, NC to Greensboro Bus Stopbus bus
    3. Take the train from Greensboro to Selma Stationtrain train
    4. Take the train from Selma Station to Charleston Amtrak Stationtrain train
    5. Take the bus from Charleston Bus Station to Myrtle Beach Bus Stationbus bus
    17h 13m
    $160–324

  7. Drive, bus #2 (Greyhound)

    1. Drive from Great Smoky Mountains to Asheville, NCcar car
    2. Take the bus from Asheville, NC to Raleigh Bus Stationbus bus
    3. Take the bus from Raleigh Bus Station to Myrtle Beach Bus Stationbus bus
    18h 23m
    $114–225

Mcghee Tyson Airport (TYS) to Myrtle Beach (MYR) flights

Calendar65Weekly Planes
Duration4h 30mAverage Duration
Ticket$63Cheapest Price
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Questions & Answers

Map of how to get from Great Smoky Mountains to Myrtle Beach.ExpandLaunch map view
  • Distance: 385.6 mi
  • Duration: 5h 19m

What companies run services between Great Smoky Mountains, TN, USA and Myrtle Beach, SC, USA?

There is no direct connection from Great Smoky Mountains to Myrtle Beach. However, you can drive to Mcghee Tyson Airport (TYS) airport, fly to Myrtle Beach (MYR), then take the taxi to Myrtle Beach. Alternatively, you can take a vehicle from Great Smoky Mountains to Myrtle Beach Bus Station via Asheville, NC, Winston Salem(Trans Center), Charlotte Bus Station, and Camden in around 13h 43m.

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Train operators
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