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How to get fromGreat Smoky Mountains to New Orleansby car, plane, bus, or train

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There are 6 ways to get from Great Smoky Mountains to New Orleans by car, plane, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive to Mcghee Tyson Airport, fly

    best
    1. Drive from Great Smoky Mountains to Mcghee Tyson Airport (TYS)car car
    2. Fly from Mcghee Tyson Airport (TYS) to Louis Armstrong New Orleans International Airport (MSY)plane plane TYS - MSY
    6h 31m
    $122–669

  2. Drive to Asheville Regional Airport, fly

    cheapest
    1. Drive from Great Smoky Mountains to Asheville-Airport-AVLcar car
    2. Fly from Asheville Regional Airport (AVL) to Louis Armstrong New Orleans International Airport (MSY)plane plane AVL - MSY
    6h 41m
    $96–474

  3. Drive, bus

    1. Drive from Great Smoky Mountains to Knoxvillecar car
    2. Take the bus from Knoxville to Nashvillebus bus Nyc
    3. Take the bus from Nashville Bus Station to Atlanta Bus Stationbus bus
    4. Take the bus from Atlanta Bus Station to New Orleans Bus Stationbus bus
    21h 29m
    $163–294

  4. Drive, bus, train

    1. Drive from Great Smoky Mountains to Asheville, NCcar car
    2. Take the bus from Asheville, NC to Greensboro Bus Stopbus bus
    3. Take the train from Greensboro to New Orleans Union Passenger Terminaltrain train
    27h 58m
    $310–670

  5. Drive 644.3 mi

    1. Drive from Great Smoky Mountains to New Orleanscar car 644.3 mi
    11h 47m
    $118–170

  6. Drive, bus via New South Memphis

    1. Drive from Great Smoky Mountains to Knoxvillecar car
    2. Take the bus from Knoxville to Memphis - Summer Avebus bus Nyc
    3. Take the bus from Memphis Bus Station to New Orleans Bus Stationbus bus
    21h 53m
    $130–221

Mcghee Tyson Airport (TYS) to Louis Armstrong New Orleans International Airport (MSY) flights

Calendar48Weekly Planes
Duration4h 31mAverage Duration
Ticket$114Cheapest Price
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Questions & Answers

Map of how to get from Great Smoky Mountains to New Orleans.ExpandLaunch map view
  • Distance: 614.3 mi
  • Duration: 6h 31m

What companies run services between Great Smoky Mountains, TN, USA and New Orleans, LA, USA?

There is no direct connection from Great Smoky Mountains to New Orleans. However, you can drive to Mcghee Tyson Airport (TYS) airport, fly to Louis Armstrong New Orleans International Airport (MSY), walk to Kenner Terminal Parking Garage, then take the bus to Tulane @ Loyola. Alternatively, you can take a vehicle from Great Smoky Mountains to New Orleans Bus Station via Knoxville, Nashville, Charlotte Pike & Lellyett St Eb, Central 5Th Ave - Bay 1, Central 4Th Ave - Bay 13, Fulton Station Outbound, Nashville Bus Station, and Atlanta Bus Station in around 21h 29m.

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