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How to get fromGreat Smoky Mountains to Niagara Fallsby car, plane, bus, or train

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There are 10 ways to get from Great Smoky Mountains to Niagara Falls by car, plane, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive to Mcghee Tyson Airport, fly to Buffalo Niagara International Airport, bus

    best
    1. Drive from Great Smoky Mountains to Mcghee Tyson Airport (TYS)car car
    2. Fly from Mcghee Tyson Airport (TYS) to Buffalo Niagara International Airport (BUF)plane plane TYS - BUF
    3. Take the bus from Buffalo Niagara International Airport to Niagara Falls USAbus bus
    7h 31m
    $176–875

  2. Drive, bus

    cheapest
    1. Drive from Great Smoky Mountains to New Leicester Hwy at Walgreenscar car
    2. Take the bus from Asheville, NC to Winston Salem(Trans Center)bus bus
    3. Take the bus from Winston Salem(Trans Center) to Columbus - Mound Stbus bus
    4. Take the bus from Columbus - Mound St to Buffalo, NYbus bus
    25h 45m
    $108–237

  3. Drive, bus, train

    1. Drive from Great Smoky Mountains to Knoxville, TNcar car
    2. Take the bus from Knoxville, TN to New York, NYbus bus Ny
    3. Take the train from Ny Moynihan Train Hall At Penn Station to Niagara Falls Amtrak Stationtrain train
    24h 35m
    $250–440

  4. Drive, bus, train via Greensboro

    1. Drive from Great Smoky Mountains to Asheville, NCcar car
    2. Take the bus from Asheville, NC to Greensboro Bus Stopbus bus
    3. Take the train from Greensboro to Ny Moynihan Train Hall At Penn Stationtrain train
    4. Take the train from Ny Moynihan Train Hall At Penn Station to Niagara Falls Amtrak Stationtrain train
    27h 39m
    $340–720

  5. Drive 739.4 mi

    1. Drive from Great Smoky Mountains to Niagara Fallscar car 739.4 mi
    13h 28m
    $135–195

  6. Drive to Asheville Regional Airport, fly to Buffalo Niagara International Airport, bus

    1. Drive from Great Smoky Mountains to Asheville-Airport-AVLcar car
    2. Fly from Asheville Regional Airport (AVL) to Buffalo Niagara International Airport (BUF)plane plane AVL - BUF
    3. Take the bus from Buffalo Niagara International Airport to Niagara Falls USAbus bus
    8h 5m
    $120–630

  7. Drive to Mcghee Tyson Airport, fly to Toronto Island Airport, bus

    1. Drive from Great Smoky Mountains to Mcghee Tyson Airport (TYS)car car
    2. Fly from Mcghee Tyson Airport (TYS) to Toronto Island Airport (YTZ)plane plane TYS - YTZ
    3. Take the bus from Toronto Union Station to Niagara Falls, ONbus bus
    9h 2m
    $118–621

  8. Drive to Mcghee Tyson Airport, fly to Toronto Pearson International Airport, bus

    1. Drive from Great Smoky Mountains to Mcghee Tyson Airport (TYS)car car
    2. Fly from Mcghee Tyson Airport (TYS) to Toronto Pearson International Airport (YYZ)plane plane TYS - YYZ
    3. Take the bus from Toronto Union Station to Niagara Falls, ONbus bus
    8h 52m
    $114–560

  9. Drive, bus, train via Niagara Falls

    1. Drive from Great Smoky Mountains to Knoxville, TNcar car
    2. Take the bus from Knoxville, TN to New York, NYbus bus Ny
    3. Take the train from New York Penn Station to Niagara Fallstrain train
    25h 14m
    $230–430

  10. Drive, bus via New York

    1. Drive from Great Smoky Mountains to Knoxville, TNcar car
    2. Take the bus from Knoxville, TN to New York, NYbus bus Ny
    3. Take the bus from New York Midtown to Niagara Falls USAbus bus
    25h 25m
    $183–258

Mcghee Tyson Airport (TYS) to Buffalo Niagara International Airport (BUF) flights

Calendar98Weekly Planes
Duration5h 9mAverage Duration
Ticket$162Cheapest Price
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Questions & Answers

Map of how to get from Great Smoky Mountains to Niagara Falls.ExpandLaunch map view
  • Distance: 657.8 mi
  • Duration: 7h 31m

What companies run services between Great Smoky Mountains, TN, USA and Niagara Falls, NY, USA?

There is no direct connection from Great Smoky Mountains to Niagara Falls. However, you can drive to Mcghee Tyson Airport (TYS) airport, fly to Buffalo Niagara International Airport (BUF), walk to Buffalo Niagara International Airport, then take the bus to Niagara Falls USA. Alternatively, you can take a vehicle from Great Smoky Mountains to Niagara Falls Amtrak Station via Knoxville, TN, New York, NY, East Broadway, 34 St-Herald Sq, and Ny Moynihan Train Hall At Penn Station in around 24h 35m.

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