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How to get fromGreat Smoky Mountains to Port Saint Lucieby car, plane, bus, or train

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There are 10 ways to get from Great Smoky Mountains to Port Saint Lucie by car, plane, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive to Mcghee Tyson Airport, fly to Orlando Sanford, drive

    best
    1. Drive from Great Smoky Mountains to Mcghee Tyson Airport (TYS)car car
    2. Fly from Mcghee Tyson Airport (TYS) to Orlando Sanford (SFB)plane plane TYS - SFB
    3. Drive from Orlando-Sanford-Airport-SFB to Port Saint Luciecar car
    5h 59m
    $120–551

  2. Drive to Asheville Regional Airport, fly to President Donald J. Trump International Airport, bus

    cheapest
    1. Drive from Great Smoky Mountains to Asheville-Airport-AVLcar car
    2. Fly from Asheville Regional Airport (AVL) to President Donald J. Trump International Airport (PBI)plane plane AVL - PBI
    3. Take the bus from WPB ITC at BAY D to GATLIN BLVD at I-95 P/R LOTbus bus
    8h 20m
    $99–467

  3. Drive, bus

    1. Drive from Great Smoky Mountains to Knoxvillecar car
    2. Take the bus from Knoxville to Nashvillebus bus Nyc
    3. Take the bus from Nashville Bus Station to Atlanta Bus Stationbus bus
    4. Take the bus from Atlanta Bus Station to Port St Luciebus bus
    24h 33m
    $178–294

  4. Drive, bus, train

    1. Drive from Great Smoky Mountains to Asheville, NCcar car
    2. Take the bus from Asheville, NC to Greensboro Bus Stopbus bus
    3. Take the train from Greensboro to Carytrain train
    4. Take the train from Cary to Kissimmee Amtrak Stationtrain train
    5. Take the bus from Kissimmee -1471 East Osceola Parkway to Fort Piercebus bus
    26h 43m
    $283–582

  5. Drive 678.7 mi

    1. Drive from Great Smoky Mountains to Port Saint Luciecar car 678.7 mi
    14h 2m
    $124–179

  6. Drive to Mcghee Tyson Airport, fly to Fort Lauderdale–Hollywood International Airport, bus

    1. Drive from Great Smoky Mountains to Mcghee Tyson Airport (TYS)car car
    2. Fly from Mcghee Tyson Airport (TYS) to Fort Lauderdale–Hollywood International Airport (FLL)plane plane TYS - FLL
    3. Take the bus from Fort Lauderdale - Broward Blvd Park and Ride to Fort Piercebus bus
    7h 36m
    $141–661

  7. Drive to Asheville Regional Airport, fly to Fort Lauderdale–Hollywood International Airport, bus

    1. Drive from Great Smoky Mountains to Asheville-Airport-AVLcar car
    2. Fly from Asheville Regional Airport (AVL) to Fort Lauderdale–Hollywood International Airport (FLL)plane plane AVL - FLL
    3. Take the bus from Fort Lauderdale - Broward Blvd Park and Ride to Fort Piercebus bus
    7h 47m
    $115–466

  8. Drive to Mcghee Tyson Airport, fly to Orlando, bus

    1. Drive from Great Smoky Mountains to Mcghee Tyson Airport (TYS)car car
    2. Fly from Mcghee Tyson Airport (TYS) to Orlando (MCO)plane plane TYS - MCO
    3. Take the bus from Kissimmee -1471 East Osceola Parkway to Fort Piercebus bus
    8h 3m
    $130–560

  9. Drive to Mcghee Tyson Airport, fly to Miami International Airport, bus

    1. Drive from Great Smoky Mountains to Mcghee Tyson Airport (TYS)car car
    2. Fly from Mcghee Tyson Airport (TYS) to Miami International Airport (MIA)plane plane TYS - MIA
    3. Take the bus from Sheridan Tri-Rail Station to Fort Piercebus bus
    8h 2m
    $144–662

  10. Drive, bus via Raleigh

    1. Drive from Great Smoky Mountains to New Leicester Hwy at Walgreenscar car
    2. Take the bus from Asheville, NC to Raleigh Bus Stationbus bus
    3. Take the bus from Raleigh Bus Station to Orlando Bus Stationbus bus
    4. Take the bus from Orlando to Fort Piercebus bus
    24h 58m
    $171–287

Mcghee Tyson Airport (TYS) to Orlando Sanford (SFB) flights

Calendar11Weekly Planes
Duration1h 37mAverage Duration
Ticket$87Cheapest Price
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Questions & Answers

Map of how to get from Great Smoky Mountains to Port Saint Lucie.ExpandLaunch map view
  • Distance: 703.3 mi
  • Duration: 5h 59m

What companies run services between Great Smoky Mountains, TN, USA and Port Saint Lucie, FL, USA?

There is no direct connection from Great Smoky Mountains to Port Saint Lucie. However, you can drive to Mcghee Tyson Airport (TYS) airport, fly to Orlando Sanford (SFB), then drive to Port Saint Lucie. Alternatively, you can take a vehicle from Great Smoky Mountains to SW PSL Blvd & SE Bayshore Blvd via Knoxville, Nashville, Charlotte Pike & Lellyett St Eb, Central 5Th Ave - Bay 1, Central 4Th Ave - Bay 13, Fulton Station Outbound, Nashville Bus Station, Atlanta Bus Station, and SW Gatlin Blvd & SW Brescia St in around 24h 33m.

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