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How to get fromGreat Smoky Mountains to San Antonioby car, plane, or bus

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There are 5 ways to get from Great Smoky Mountains to San Antonio by car, plane, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive to Mcghee Tyson Airport, fly to San Antonio International Airport

    best
    1. Drive from Great Smoky Mountains to Mcghee Tyson Airport (TYS)car car
    2. Fly from Mcghee Tyson Airport (TYS) to San Antonio International Airport (SAT)plane plane TYS - SAT
    6h 48m
    $183–918

  2. Drive to Asheville Regional Airport, fly to San Antonio International Airport

    cheapest
    1. Drive from Great Smoky Mountains to Asheville-Airport-AVLcar car
    2. Fly from Asheville Regional Airport (AVL) to San Antonio International Airport (SAT)plane plane AVL - SAT
    7h 9m
    $147–673

  3. Drive, bus

    1. Drive from Great Smoky Mountains to Knoxvillecar car
    2. Take the bus from Knoxville to Jacksonbus bus Nyc
    3. Take the bus from El Mezcal Grocery - Jackson, TN to Tornado Bus Co - West Memphisbus bus
    4. Take the bus from Tornado Bus Co - West Memphis to Tornado Bus Co - San Antoniobus bus
    26h 34m
    $226–497

  4. Drive 1,166.1 mi

    1. Drive from Great Smoky Mountains to San Antoniocar car 1,166.1 mi
    19h 31m
    $213–308

  5. Drive to Mcghee Tyson Airport, fly to Austin-Bergstrom International Airport, bus

    1. Drive from Great Smoky Mountains to Mcghee Tyson Airport (TYS)car car
    2. Fly from Mcghee Tyson Airport (TYS) to Austin-Bergstrom International Airport (AUS)plane plane TYS - AUS
    3. Take the bus from Austin Eastside Bus Plaza to San Antonio Bus Stationbus bus
    7h 38m
    $184–893

Mcghee Tyson Airport (TYS) to San Antonio International Airport (SAT) flights

Calendar91Weekly Planes
Duration5h 16mAverage Duration
Ticket$176Cheapest Price
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Questions & Answers

Map of how to get from Great Smoky Mountains to San Antonio.ExpandLaunch map view
  • Distance: 1,014.7 mi
  • Duration: 6h 48m

What companies run services between Great Smoky Mountains, TN, USA and San Antonio, TX, USA?

There is no direct connection from Great Smoky Mountains to San Antonio. However, you can drive to Mcghee Tyson Airport (TYS) airport, fly to San Antonio International Airport (SAT), walk to San Antonio International Airport, then take the line 7 bus to St. Mary's & Pecan. Alternatively, you can take a vehicle from Great Smoky Mountains to S. St. Mary's & Nueva via Knoxville, Jackson, El Mezcal Grocery - Jackson, TN, Tornado Bus Co - West Memphis, Tornado Bus Co - San Antonio, and I-35 S Access & Yarrow Blvd in around 26h 34m.

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