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How to get fromGreat Smoky Mountains to Tupeloby car, plane, or bus

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There are 5 ways to get from Great Smoky Mountains to Tupelo by car, plane, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive, fly to Golden Triangle Regional Airport

    best
    1. Drive from Great Smoky Mountains to Mcghee Tyson Airport (TYS)car car
    2. Fly from Mcghee Tyson Airport (TYS) to Golden Triangle Regional Airport (GTR)plane plane TYS - GTR
    3. Drive from Golden Triangle Regional Airport (GTR) to Tupelocar car
    7h
    $97–503

  2. Drive 393.2 mi

    cheapest
    1. Drive from Great Smoky Mountains to Tupelocar car 393.2 mi
    8h 22m
    $72–104

  3. Drive, bus

    1. Drive from Great Smoky Mountains to Knoxvillecar car
    2. Take the bus from Knoxville to Memphis - Summer Avebus bus Nyc
    3. Take the bus from Memphis Bus Station to Tupelobus bus
    11h 48m
    $125–188

  4. Drive, fly to Tupelo Regional Airport

    1. Drive from Great Smoky Mountains to Mcghee Tyson Airport (TYS)car car
    2. Fly from Mcghee Tyson Airport (TYS) to Tupelo Regional Airport (TUP)plane plane TYS - TUP
    7h 50m
    $115–534

  5. Drive, bus via Nashville

    1. Drive from Great Smoky Mountains to Knoxvillecar car
    2. Take the bus from Knoxville to Nashvillebus bus Nyc
    3. Take the bus from Nashville Bus Station to Memphis Bus Stationbus bus
    4. Take the bus from Memphis Bus Station to Tupelobus bus
    12h 54m
    $114–192

Mcghee Tyson Airport (TYS) to Golden Triangle Regional Airport (GTR) flights

Calendar14Weekly Planes
Duration5h 48mAverage Duration
Ticket$78Cheapest Price
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Questions & Answers

Map of how to get from Great Smoky Mountains to Tupelo.ExpandLaunch map view
  • Distance: 429.6 mi
  • Duration: 7h

What companies run services between Great Smoky Mountains, TN, USA and Tupelo, MS, USA?

There is no direct connection from Great Smoky Mountains to Tupelo. However, you can drive to Mcghee Tyson Airport (TYS) airport, fly to Golden Triangle Regional Airport (GTR), then drive to Tupelo. Alternatively, you can take a vehicle from Great Smoky Mountains to Tupelo via Knoxville, Memphis - Summer Ave, Memphis Bus Station, and Tupelo in around 11h 48m.

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