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How to get fromGreensboro to St. Louisby plane, bus (Greyhound, Flixbus), train, bus, car, bus (Greyhound), or train (Amtrak)

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There are 8 ways to get from Greensboro to St. Louis by plane, bus (Greyhound, Flixbus), train, bus, car, bus (Greyhound), or train (Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Piedmont Triad International Airport

    best
    1. Fly from Piedmont Triad International Airport (GSO) to Lambert–St. Louis International Airport (STL)plane plane GSO - STL
    4h 51m
    $154–689

  2. Bus via Columbus

    cheapest
    1. Take the bus from Winston Salem(Trans Center) to Columbus - Mound Stbus bus Charlotte
    2. Take the bus from Columbus to St Louis Bus Stationbus bus Greyhound US0421
    21h 52m
    $106–206

  3. Bus

    1. Take the bus from Greensboro Bus Stop to Atlanta Bus Stationbus bus Greyhound US0670
    2. Take the bus from Atlanta Bus Station to St Louis Bus Stationbus bus Greyhound US0186
    19h 35m
    $136–222

  4. Train, bus

    1. Take the train from Greensboro to Charlottesvilletrain train
    2. Take the train from Charlottesville to Indianapolistrain train
    3. Take the bus from Indianapolis Union Station to St Louis Bus Stationbus bus
    24h 43m
    $240–509

  5. Drive  703.5 mi

    1. Drive from Greensboro to St. Louiscar car 703.5 mi
    12h 49m
    $129–186

  6. Train to Raleigh-Durham International Airport, fly

    1. Take the train from Greensboro to Durham Amtrak Stationtrain train
    2. Fly from Raleigh-Durham International Airport (RDU) to Lambert–St. Louis International Airport (STL)plane plane RDU - STL
    6h 16m
    $571–1,140

  7. Train to Charlotte Douglas International Airport, fly

    1. Take the train from Greensboro to Charlotte Amtrak Stationtrain train
    2. Fly from Charlotte Douglas International Airport (CLT) to Lambert–St. Louis International Airport (STL)plane plane CLT - STL
    6h 22m
    $128–612

  8. Train (Amtrak)

    1. Take the train from Greensboro to Carytrain train
    2. Take the train from Cary to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Louistrain train
    33h 25m
    $369–862

Greensboro to St. Louis by bus

Calendar12Weekly Buses
Duration19h 35mAverage Duration
Ticket$136Cheapest Price
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Questions & Answers

Map of how to get from Greensboro to St. Louis.ExpandLaunch map view
  • Distance: 626 mi
  • Duration: 4h 51m

What companies run services between Greensboro, NC, USA and St. Louis, MO, USA?

Delta, American Airlines, and United Airlines fly from Piedmont Triad International Airport (GSO) to Lambert–St. Louis International Airport (STL) hourly. Alternatively, you can take a bus from Greensboro Bus Stop to St Louis Bus Station via Atlanta Bus Station in around 19h 35m.

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