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How to get fromGreensboro to St. Louisby plane, bus (Greyhound, Flixbus), train, bus, car, bus (Greyhound), or train (Amtrak)

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There are 8 ways to get from Greensboro to St. Louis by plane, bus (Greyhound, Flixbus), train, bus, car, bus (Greyhound), or train (Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Piedmont Triad International Airport

    best
    1. Fly from Piedmont Triad International Airport (GSO) to Lambert–St. Louis International Airport (STL)plane plane GSO - STL
    4h 54m
    $174–789

  2. Drive 703.5 mi

    cheapest
    1. Drive from Greensboro to St. Louiscar car 703.5 mi
    12h 49m
    $129–186

  3. Bus

    1. Take the bus from Greensboro Bus Stop to Atlanta Bus Stationbus bus FlixBus N2471 / ...
    2. Take the bus from Atlanta Bus Station to St Louis Bus Stationbus bus FlixBus N2521
    17h 40m
    $138–270

  4. Train, bus

    1. Take the train from Greensboro to Charlottesvilletrain train
    2. Take the train from Charlottesville to Indianapolistrain train
    3. Take the bus from Indianapolis Union Station to St Louis Bus Stationbus bus
    24h 43m
    $306–602

  5. Train to Raleigh-Durham International Airport, fly

    1. Take the train from Greensboro to Durham Amtrak Stationtrain train
    2. Fly from Raleigh-Durham International Airport (RDU) to Lambert–St. Louis International Airport (STL)plane plane RDU - STL
    6h 11m
    $575–1,044

  6. Train to Charlotte Douglas International Airport, fly

    1. Take the train from Greensboro to Charlotte Amtrak Stationtrain train
    2. Fly from Charlotte Douglas International Airport (CLT) to Lambert–St. Louis International Airport (STL)plane plane CLT - STL
    6h 25m
    $159–719

  7. Bus via Columbus

    1. Take the bus from Winston Salem(Trans Center) to Columbus - Mound Stbus bus Charlotte
    2. Take the bus from Columbus to St Louis Bus Stationbus bus Greyhound US0421
    21h 52m
    $136–236

  8. Train (Amtrak)

    1. Take the train from Greensboro to Carytrain train
    2. Take the train from Cary to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Louistrain train
    33h 25m
    $464–937

Greensboro to St. Louis by bus

Calendar19Weekly Buses
Duration17h 40mAverage Duration
Ticket$138Cheapest Price
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Questions & Answers

Map of how to get from Greensboro to St. Louis.ExpandLaunch map view
  • Distance: 626 mi
  • Duration: 4h 54m

What companies run services between Greensboro, NC, USA and St. Louis, MO, USA?

American Airlines, Delta, and United Airlines fly from Piedmont Triad International Airport (GSO) to Lambert–St. Louis International Airport (STL) hourly. Alternatively, you can take a bus from Greensboro Bus Stop to St Louis Bus Station via Atlanta Bus Station in around 17h 40m.

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