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How to get fromGreenville to Charlestonby taxi, plane, car, train, or bus

Find Transport to Charleston

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There are 6 ways to get from Greenville to Charleston by taxi, plane, car, train, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Taxi to Monroe Regional Airport, fly to Charleston International Airport

    best
    1. Take the taxi from Greenville to Monroe Regional Airport (MLU)taxi taxi
    2. Fly from Monroe Regional Airport (MLU) to Charleston International Airport (CHS)plane plane MLU - CHS
    8h 46m
    $104–448

  2. Drive, train, bus

    1. Drive from Greenville to Yazoo City Amtrak Stationcar car
    2. Take the train from Yazoo City Amtrak Station to Jacksontrain train
    3. Take the bus from Jackson to Atlanta Bus Stationbus bus
    4. Take the bus from Atlanta Bus Station to Charleston Bus Stationbus bus
    25h 52m
    $151–293

  3. Drive 709.4 mi

    1. Drive from Greenville to Charlestoncar car 709.4 mi
    12h 51m
    $130–187

  4. Fly Greenville International Airport to Charleston International Airport

    1. Fly from Greenville International Airport (GLH) to Charleston International Airport (CHS)plane plane GLH - CHS
    6h 21m
    $144–628

  5. Drive, train to Jackson/Vicksburg, fly to Charleston International Airport

    1. Drive from Greenville to Yazoo City Amtrak Stationcar car
    2. Take the train from Yazoo City Amtrak Station to Jacksontrain train
    3. Fly from Jackson/Vicksburg (JAN) to Charleston International Airport (CHS)plane plane JAN - CHS
    9h 7m
    $134–501

  6. Fly Greenville International Airport to Hilton Head Airport, drive

    1. Fly from Greenville International Airport (GLH) to Hilton Head Airport (HHH)plane plane GLH - HHH
    2. Drive from Hilton Head Airport (HHH) to Charlestoncar car
    22h 38m
    $150–603

Monroe Regional Airport (MLU) to Charleston International Airport (CHS) flights

Calendar34Weekly Planes
Duration6h 4mAverage Duration
Ticket$80Cheapest Price
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Questions & Answers

Map of how to get from Greenville to Charleston.ExpandLaunch map view
  • Distance: 812.9 mi
  • Duration: 8h 46m

What companies run services between Greenville, MS, USA and Charleston, SC, USA?

Key Lime, Delta, and American Airlines fly from Greenville International Airport (GLH) to Charleston International Airport (CHS) twice daily.

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