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How to get fromGreenville to Chicagoby car, plane, train, or bus

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There are 6 ways to get from Greenville to Chicago by car, plane, train, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive to Bill And Hillary Clinton National Airport, fly to Chicago O'Hare International Airport

    best
    1. Drive from Greenville to Bill And Hillary Clinton National Airport (LIT)car car
    2. Fly from Bill And Hillary Clinton National Airport (LIT) to Chicago O'Hare International Airport (ORD)plane plane LIT - ORD
    5h 34m
    $109–494

  2. Fly Greenville International Airport to Chicago O'Hare International Airport

    cheapest
    1. Fly from Greenville International Airport (GLH) to Chicago O'Hare International Airport (ORD)plane plane GLH - ORD
    6h 26m
    $99–401

  3. Drive, train (Amtrak)

    1. Drive from Greenville to Greenwood Amtrak Stationcar car
    2. Take the train from Greenwood Amtrak Station to Chicago Union Stationtrain train City of New Orleans
    14h 41m
    $220–444

  4. Drive, train, bus

    1. Drive from Greenville to Yazoo City Amtrak Stationcar car
    2. Take the train from Yazoo City Amtrak Station to Jacksontrain train
    3. Take the bus from Jackson to Memphis Bus Stationbus bus
    4. Take the bus from Memphis Bus Station to Chicago Bus Stationbus bus
    17h 39m
    $138–275

  5. Drive 677.7 mi

    1. Drive from Greenville to Chicagocar car 677.7 mi
    11h 23m
    $124–179

  6. Fly Greenville International Airport to Chicago Midway International Airport

    1. Fly from Greenville International Airport (GLH) to Chicago Midway International Airport (MDW)plane plane GLH - MDW
    5h 18m
    $114–461

Bill And Hillary Clinton National Airport (LIT) to Chicago O'Hare International Airport (ORD) flights

Calendar61Weekly Planes
Duration3h 7mAverage Duration
Ticket$82Cheapest Price
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Questions & Answers

Map of how to get from Greenville to Chicago.ExpandLaunch map view
  • Distance: 717.5 mi
  • Duration: 5h 34m

What companies run services between Greenville, MS, USA and Chicago, IL, USA?

Key Lime, Southwest Airlines, and Frontier Airlines fly from Greenville International Airport (GLH) to Chicago Midway International Airport (MDW) once daily.

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