Rome2Rio

How to get fromGreenville to Knoxvilleby taxi, plane, car, train, or bus

Find Transport to Knoxville

See all options

There are 10 ways to get from Greenville to Knoxville by taxi, plane, car, train, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Taxi to Monroe Regional Airport, fly to Mcghee Tyson Airport

    best
    1. Take the taxi from Greenville to Monroe Regional Airport (MLU)taxi taxi
    2. Fly from Monroe Regional Airport (MLU) to Mcghee Tyson Airport (TYS)plane plane MLU - TYS
    6h 34m
    $207–846

  2. Drive 533.6 mi

    cheapest
    1. Drive from Greenville to Knoxvillecar car 533.6 mi
    9h 13m
    $98–141

  3. Drive, train, bus

    1. Drive from Greenville to Yazoo City Amtrak Stationcar car
    2. Take the train from Yazoo City Amtrak Station to Jacksontrain train
    3. Take the bus from Jackson to Atlanta Bus Stationbus bus
    4. Take the bus from Atlanta Bus Station to New York City Chinatownbus bus
    5. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    47h 50m
    $322–505

  4. Drive, train, bus via New Orleans

    1. Drive from Greenville to Yazoo City Amtrak Stationcar car
    2. Take the train from Yazoo City Amtrak Station to New Orleans Union Passenger Terminaltrain train
    3. Take the train from New Orleans Union Passenger Terminal to Ny Moynihan Train Hall At Penn Stationtrain train
    4. Take the bus from New York to Knoxvillebus bus Nyc
    2d 5h
    $687–1,323

  5. Drive, train to Jackson/Vicksburg, fly to Mcghee Tyson Airport

    1. Drive from Greenville to Yazoo City Amtrak Stationcar car
    2. Take the train from Yazoo City Amtrak Station to Jacksontrain train
    3. Fly from Jackson/Vicksburg (JAN) to Mcghee Tyson Airport (TYS)plane plane JAN - TYS
    7h 20m
    $228–870

  6. Fly Greenville International Airport to Mcghee Tyson Airport

    1. Fly from Greenville International Airport (GLH) to Mcghee Tyson Airport (TYS)plane plane GLH - TYS
    5h 5m
    $277–1,046

  7. Fly Greenville International Airport to Hartsfield-Jackson Atlanta International Airport, drive

    1. Fly from Greenville International Airport (GLH) to Hartsfield-Jackson Atlanta International Airport (ATL)plane plane GLH - ATL
    2. Drive from Atlanta-Airport-ATL to Knoxvillecar car
    5h 18m
    $307–686

  8. Fly Greenville International Airport to Chattanooga Metropolitan Airport, drive

    1. Fly from Greenville International Airport (GLH) to Chattanooga Metropolitan Airport (CHA)plane plane GLH - CHA
    2. Drive from Chattanooga Metropolitan Airport (CHA) to Knoxvillecar car
    6h 51m
    $220–954

  9. Fly Greenville International Airport to Asheville Regional Airport, drive

    1. Fly from Greenville International Airport (GLH) to Asheville Regional Airport (AVL)plane plane GLH - AVL
    2. Drive from Asheville-Airport-AVL to Knoxvillecar car
    6h 28m
    $144–561

  10. Drive, train, bus via New Orleans #2

    1. Drive from Greenville to Yazoo City Amtrak Stationcar car
    2. Take the train from Yazoo City Amtrak Station to New Orleans Union Passenger Terminaltrain train
    3. Take the train from New Orleans Union Passenger Terminal to Ny Moynihan Train Hall At Penn Stationtrain train
    4. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    2d 5h
    $642–1,233

Monroe Regional Airport (MLU) to Mcghee Tyson Airport (TYS) flights

Calendar29Weekly Planes
Duration5h 13mAverage Duration
Ticket$131Cheapest Price
See schedules

Questions & Answers

Map of how to get from Greenville to Knoxville.ExpandLaunch map view
  • Distance: 626.6 mi
  • Duration: 6h 34m

What companies run services between Greenville, MS, USA and Knoxville, TN, USA?

Key Lime, Delta, and American Airlines fly from Greenville International Airport (GLH) to Mcghee Tyson Airport (TYS) 5 times a week.

Airlines
Train operators
Bus operators
Other operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound