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How to get fromGreenville to Louisvilleby taxi, plane, car, train, or bus

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There are 8 ways to get from Greenville to Louisville by taxi, plane, car, train, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Taxi to Monroe Regional Airport, fly to Louisville International Airport

    best
    1. Take the taxi from Greenville to Monroe Regional Airport (MLU)taxi taxi
    2. Fly from Monroe Regional Airport (MLU) to Louisville International Airport (SDF)plane plane MLU - SDF
    8h 52m
    $133–679

  2. Drive 519.8 mi

    cheapest
    1. Drive from Greenville to Louisvillecar car 519.8 mi
    9h 24m
    $95–137

  3. Drive, train, bus

    1. Drive from Greenville to Yazoo City Amtrak Stationcar car
    2. Take the train from Yazoo City Amtrak Station to Jacksontrain train
    3. Take the bus from Jackson to Memphis Bus Stationbus bus
    4. Take the bus from Tornado Bus Co - West Memphis to La Tropicana - Louisville, KYbus bus
    16h 17m
    $174–353

  4. Drive, train, bus via Champaign

    1. Drive from Greenville to Greenwood Amtrak Stationcar car
    2. Take the train from Greenwood Amtrak Station to Champaign-Urbanatrain train
    3. Take the bus from Champaign Intermodal Trans Ctr to Indianapolis Union Stationbus bus
    4. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    18h 21m
    $209–444

  5. Drive, train to Jackson/Vicksburg, fly to Louisville International Airport

    1. Drive from Greenville to Yazoo City Amtrak Stationcar car
    2. Take the train from Yazoo City Amtrak Station to Jacksontrain train
    3. Fly from Jackson/Vicksburg (JAN) to Louisville International Airport (SDF)plane plane JAN - SDF
    8h 57m
    $149–653

  6. Fly Greenville International Airport to Louisville International Airport

    1. Fly from Greenville International Airport (GLH) to Louisville International Airport (SDF)plane plane GLH - SDF
    6h 38m
    $163–729

  7. Fly Greenville International Airport to Blue Grass Airport, drive

    1. Fly from Greenville International Airport (GLH) to Blue Grass Airport (LEX)plane plane GLH - LEX
    2. Drive from Lexington-Airport-LEX to Louisvillecar car
    6h 25m
    $255–1,145

  8. Drive, train, bus via Carbondale

    1. Drive from Greenville to Greenwood Amtrak Stationcar car
    2. Take the train from Greenwood Amtrak Station to Carbondaletrain train
    3. Take the bus from Carbondale Intermodal Station to Nashville Bus Stationbus bus
    4. Take the bus from Nashville to Louisville, KYbus bus
    18h 14m
    $170–349

Monroe Regional Airport (MLU) to Louisville International Airport (SDF) flights

Calendar41Weekly Planes
Duration5h 51mAverage Duration
Ticket$117Cheapest Price
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Questions & Answers

Map of how to get from Greenville to Louisville.ExpandLaunch map view
  • Distance: 635.3 mi
  • Duration: 8h 52m

What companies run services between Greenville, MS, USA and Louisville, KY, USA?

Key Lime, Delta, and American Airlines fly from Greenville International Airport (GLH) to Louisville International Airport (SDF) twice daily.

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