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How to get fromGreenville to St. Louisby car, train, bus, or plane

Find Transport to St. Louis

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There are 6 ways to get from Greenville to St. Louis by car, train, bus, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive, train, bus

    best
    1. Drive from Greenville to Greenwood Amtrak Stationcar car
    2. Take the train from Greenwood Amtrak Station to Carbondaletrain train
    3. Take the bus from Carbondale Intermodal Station to St Louis Bus Stationbus bus
    11h 34m
    $135–289

  2. Drive 429.3 mi

    cheapest
    1. Drive from Greenville to St. Louiscar car 429.3 mi
    7h 20m
    $79–114

  3. Drive, train, bus via Jackson

    1. Drive from Greenville to Yazoo City Amtrak Stationcar car
    2. Take the train from Yazoo City Amtrak Station to Jacksontrain train
    3. Take the bus from Jackson to St Louis Bus Stationbus bus
    13h 39m
    $103–200

  4. Drive to Bill And Hillary Clinton National Airport, fly

    1. Drive from Greenville to Bill And Hillary Clinton National Airport (LIT)car car
    2. Fly from Bill And Hillary Clinton National Airport (LIT) to Lambert–St. Louis International Airport (STL)plane plane LIT - STL
    7h 9m
    $180–842

  5. Drive, train to Jackson/Vicksburg, fly

    1. Drive from Greenville to Yazoo City Amtrak Stationcar car
    2. Take the train from Yazoo City Amtrak Station to Jacksontrain train
    3. Fly from Jackson/Vicksburg (JAN) to Lambert–St. Louis International Airport (STL)plane plane JAN - STL
    7h 51m
    $161–653

  6. Fly from Greenville International Airport

    1. Fly from Greenville International Airport (GLH) to Lambert–St. Louis International Airport (STL)plane plane GLH - STL
    5h 32m
    $145–629

Bill And Hillary Clinton National Airport (LIT) to Lambert–St. Louis International Airport (STL) flights

Calendar108Weekly Planes
Duration4h 59mAverage Duration
Ticket$149Cheapest Price
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Questions & Answers

Map of how to get from Greenville to St. Louis.ExpandLaunch map view
  • Distance: 491.7 mi
  • Duration: 11h 34m

What companies run services between Greenville, MS, USA and St. Louis, MO, USA?

Key Lime, Delta, and two other airlines fly from Greenville International Airport (GLH) to Lambert–St. Louis International Airport (STL) twice daily.

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Train operators
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