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How to get fromGreenville to Buffaloby plane, bus (Flixbus), bus, train, car, taxi, or bus (Greyhound)

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There are 6 ways to get from Greenville to Buffalo by plane, bus (Flixbus), bus, train, car, taxi, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Greenville–Spartanburg International Airport

    best
    1. Fly from Greenville–Spartanburg International Airport (GSP) to Buffalo Niagara International Airport (BUF)plane plane GSP - BUF
    4h 58m
    $173–777

  2. Drive 726.8 mi

    cheapest
    1. Drive from Greenville to Buffalocar car 726.8 mi
    13h 7m
    $133–192

  3. Bus via New York

    1. Take the bus from Taqueria Guadalajara - Greenville to Los Arcos Restaurant - Gastoniabus bus
    2. Take the bus from Gastonia, NC - Chester St. to New York, NYbus bus
    3. Take the bus from New York Midtown to Buffalobus bus
    23h 54m
    $216–409

  4. Bus, train

    1. Take the bus from Taqueria Guadalajara - Greenville to Charlottebus bus
    2. Take the train from Charlotte Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the train from Ny Moynihan Train Hall At Penn Station to Buffalotrain train
    27h 5m
    $388–851

  5. Taxi to Asheville Regional Airport, fly

    1. Take the taxi from Greenville to Asheville-Airport-AVLtaxi taxi
    2. Fly from Asheville Regional Airport (AVL) to Buffalo Niagara International Airport (BUF)plane plane AVL - BUF
    6h 11m
    $240–793

  6. Bus

    1. Take the bus from Taqueria Guadalajara - Greenville to Atlantabus bus
    2. Take the bus from Atlanta Bus Station to Cleveland Bus Stationbus bus
    3. Take the bus from Cleveland Bus Station to Buffalobus bus
    28h 10m
    $213–471

Greenville–Spartanburg International Airport (GSP) to Buffalo Niagara International Airport (BUF) flights

Calendar117Weekly Planes
Duration4h 38mAverage Duration
Ticket$130Cheapest Price
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Questions & Answers

Map of how to get from Greenville to Buffalo.ExpandLaunch map view
  • Distance: 614.1 mi
  • Duration: 4h 58m

What companies run services between Greenville, SC, USA and Buffalo, NY, USA?

Southwest Airlines, United Airlines, and two other airlines fly from Greenville–Spartanburg International Airport (GSP) to Buffalo Niagara International Airport (BUF) hourly. Alternatively, you can take a vehicle from Greenville to Buffalo via Taqueria Guadalajara - Greenville, Los Arcos Restaurant - Gastonia, Gastonia, NC - Chester St., New York, NY, New York City Chinatown, and New York Midtown in around 23h 54m.

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