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How to get fromGreenville to Chicagoby plane, bus (Greyhound, Flixbus), bus, train, car, taxi, or bus (Flixbus)

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There are 8 ways to get from Greenville to Chicago by plane, bus (Greyhound, Flixbus), bus, train, car, taxi, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Greenville–Spartanburg International Airport to Chicago O'Hare International Airport

    best
    1. Fly from Greenville–Spartanburg International Airport (GSP) to Chicago O'Hare International Airport (ORD)plane plane GSP - ORD
    3h 12m
    $108–423

  2. Bus

    1. Take the bus from Taqueria Guadalajara - Greenville to Atlantabus bus Charlotte
    2. Take the bus from Atlanta Bus Station to Chicago Bus Stationbus bus Greyhound US0100
    21h 15m
    $173–381

  3. Bus, train

    1. Take the bus from Taqueria Guadalajara - Greenville to Charlottebus bus
    2. Take the train from Charlotte Amtrak Station to Carytrain train
    3. Take the train from Cary to Chicago Union Stationtrain train
    33h 32m
    $458–1,021

  4. Drive 668.7 mi

    1. Drive from Greenville to Chicagocar car 668.7 mi
    12h 43m
    $122–177

  5. Taxi to Asheville Regional Airport, fly to Chicago O'Hare International Airport

    1. Take the taxi from Greenville to Asheville-Airport-AVLtaxi taxi
    2. Fly from Asheville Regional Airport (AVL) to Chicago O'Hare International Airport (ORD)plane plane AVL - ORD
    3h 49m
    $190–459

  6. Fly Greenville–Spartanburg International Airport to Chicago Midway International Airport

    1. Fly from Greenville–Spartanburg International Airport (GSP) to Chicago Midway International Airport (MDW)plane plane GSP - MDW
    4h 40m
    $128–503

  7. Taxi to Asheville Regional Airport, fly to Chicago Midway International Airport

    1. Take the taxi from Greenville to Asheville-Airport-AVLtaxi taxi
    2. Fly from Asheville Regional Airport (AVL) to Chicago Midway International Airport (MDW)plane plane AVL - MDW
    6h 5m
    $210–539

  8. Bus via Bloomington

    1. Take the bus from Taqueria Guadalajara - Greenville to Atlantabus bus
    2. Take the bus from Atlanta Bus Station to Bloomingtonbus bus
    3. Take the bus from Bloomington to Chicago Bus Stationbus bus
    21h 40m
    $178–376

Greenville–Spartanburg International Airport (GSP) to Chicago O'Hare International Airport (ORD) flights

Calendar80Weekly Planes
Duration3h 18mAverage Duration
Ticket$67Cheapest Price
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Questions & Answers

Map of how to get from Greenville to Chicago.ExpandLaunch map view
  • Distance: 609.6 mi
  • Duration: 3h 12m

What companies run services between Greenville, SC, USA and Chicago, IL, USA?

American Airlines, United Airlines, and Delta fly from Greenville–Spartanburg International Airport (GSP) to Chicago O'Hare International Airport (ORD) every 2 hours. Alternatively, you can take a vehicle from Greenville to Chicago Bus Station via Taqueria Guadalajara - Greenville, Atlanta, Doraville Station, Garnett Station, and Atlanta Bus Station in around 21h 15m.

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