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How to get fromGreenville to Des Moinesby plane, bus (Flixbus, Amtrak, Greyhound), car, taxi, or bus (Greyhound, Flixbus)

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There are 6 ways to get from Greenville to Des Moines by plane, bus (Flixbus, Amtrak, Greyhound), car, taxi, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Greenville–Spartanburg International Airport

    best
    1. Fly from Greenville–Spartanburg International Airport (GSP) to Des Moines (DSM)plane plane GSP - DSM
    5h 9m
    $238–969

  2. Drive 955.7 mi

    cheapest
    1. Drive from Greenville to Des Moinescar car 955.7 mi
    17h 27m
    $175–252

  3. Bus via Carbondale

    1. Take the bus from Taqueria Guadalajara - Greenville to Atlantabus bus
    2. Take the bus from Atlanta Bus Station to Carbondale Intermodal Stationbus bus
    3. Take the bus from Carbondale Intermodal Station to St Louis Bus Stationbus bus
    4. Take the bus from St Louis Bus Station to Des Moinesbus bus
    26h 1m
    $208–456

  4. Taxi to Asheville Regional Airport, fly

    1. Take the taxi from Greenville to Asheville-Airport-AVLtaxi taxi
    2. Fly from Asheville Regional Airport (AVL) to Des Moines (DSM)plane plane AVL - DSM
    5h 32m
    $295–885

  5. Drive to Columbia, fly

    1. Drive from Greenville to Columbia-Airport-CAEcar car
    2. Fly from Columbia (CAE) to Des Moines (DSM)plane plane CAE - DSM
    6h 23m
    $376–1,748

  6. Bus

    1. Take the bus from Taqueria Guadalajara - Greenville to Atlantabus bus
    2. Take the bus from Atlanta Bus Station to St Louis Bus Stationbus bus
    3. Take the bus from St Louis Bus Station to Des Moinesbus bus
    26h 25m
    $208–461

Greenville–Spartanburg International Airport (GSP) to Des Moines (DSM) flights

Calendar90Weekly Planes
Duration5h 57mAverage Duration
Ticket$179Cheapest Price
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Questions & Answers

Map of how to get from Greenville to Des Moines.ExpandLaunch map view
  • Distance: 791 mi
  • Duration: 5h 9m

What companies run services between Greenville, SC, USA and Des Moines, IA, USA?

United Airlines, American Airlines, and Delta fly from Greenville–Spartanburg International Airport (GSP) to Des Moines (DSM) hourly. Alternatively, you can take a vehicle from Greenville to Des Moines via Taqueria Guadalajara - Greenville, Atlanta, Doraville Station, Garnett Station, Atlanta Bus Station, Carbondale Intermodal Station, and St Louis Bus Station in around 26h 1m.

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