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How to get fromGreenville to Florida Keysby plane, bus (Flixbus, Greyhound), bus, train, car, taxi, shuttle, or bus (Greyhound)

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There are 9 ways to get from Greenville to Florida Keys by plane, bus (Flixbus, Greyhound), bus, train, car, taxi, shuttle, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Greenville–Spartanburg International Airport to Key West International Airport

    best
    1. Fly from Greenville–Spartanburg International Airport (GSP) to Key West International Airport (EYW)plane plane GSP - EYW
    7h 5m
    $198–552

  2. Drive 847.8 mi

    cheapest
    1. Drive from Greenville to Florida Keyscar car 847.8 mi
    15h 53m
    $155–224

  3. Bus

    1. Take the bus from Taqueria Guadalajara - Greenville to Atlantabus bus
    2. Take the bus from Atlanta Bus Station to Miami Airport Stationbus bus
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    24h 55m
    $184–415

  4. Bus, train

    1. Take the bus from Taqueria Guadalajara - Greenville to Charlottebus bus
    2. Take the train from Charlotte Amtrak Station to Carytrain train
    3. Take the train from Cary to Miami Amtrak Stationtrain train
    4. Take the bus from Miami Airport Station to Big Pine Keybus bus
    36h 32m
    $458–989

  5. Taxi to Asheville Regional Airport, fly to Key West International Airport

    1. Take the taxi from Greenville to Asheville-Airport-AVLtaxi taxi
    2. Fly from Asheville Regional Airport (AVL) to Key West International Airport (EYW)plane plane AVL - EYW
    6h
    $280–588

  6. Fly Greenville–Spartanburg International Airport to Miami International Airport, shuttle

    1. Fly from Greenville–Spartanburg International Airport (GSP) to Miami International Airport (MIA)plane plane GSP - MIA
    2. Take a shuttle bus from Miami, FL - International Airport to Big Pine Key, FLshuttle bus
    7h 45m
    $278–692

  7. Fly Greenville–Spartanburg International Airport to Fort Lauderdale–Hollywood International Airport, shuttle

    1. Fly from Greenville–Spartanburg International Airport (GSP) to Fort Lauderdale–Hollywood International Airport (FLL)plane plane GSP - FLL
    2. Take a shuttle bus from Fort Lauderdale, FL - International Airport to Big Pine Key, FLshuttle bus
    8h 16m
    $353–1,052

  8. Taxi to Asheville Regional Airport, fly to Fort Lauderdale–Hollywood International Airport, shuttle

    1. Take the taxi from Greenville to Asheville-Airport-AVLtaxi taxi
    2. Fly from Asheville Regional Airport (AVL) to Fort Lauderdale–Hollywood International Airport (FLL)plane plane AVL - FLL
    3. Take a shuttle bus from Fort Lauderdale, FL - International Airport to Big Pine Key, FLshuttle bus
    8h 57m
    $380–758

  9. Bus via Pembroke Pines

    1. Take the bus from Taqueria Guadalajara - Greenville to Atlantabus bus
    2. Take the bus from Atlanta Bus Station to Hollywood Sheridan Trirail Stationbus bus
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    29h 21m
    $187–421

Greenville–Spartanburg International Airport (GSP) to Key West International Airport (EYW) flights

Calendar47Weekly Planes
Duration5h 16mAverage Duration
Ticket$81Cheapest Price
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Questions & Answers

Map of how to get from Greenville to Florida Keys.ExpandLaunch map view
  • Distance: 749.7 mi
  • Duration: 7h 5m

What companies run services between Greenville, SC, USA and Florida Keys, FL, USA?

Delta, American Airlines, and Breeze Airways fly from Greenville–Spartanburg International Airport (GSP) to Key West International Airport (EYW) every 4 hours. Alternatively, you can take a vehicle from Greenville to Florida Keys via Taqueria Guadalajara - Greenville, Atlanta, Doraville Station, Garnett Station, Atlanta Bus Station, Miami Airport Station, Big Pine Key, Big Pine Key - CVS / MM30, and Sugarloaf Key - Lower - Sugarloaf Lodge in around 24h 55m.

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